STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KXG91282.1KEGG: ols:Olsu_0804 9.7e-44 dihydrofolate reductase subunit; K00287 dihydrofolate reductase. (186 aa)    
Predicted Functional Partners:
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
 
 
 0.999
KXG91008.1
Protein FolC; KEGG: apv:Apar_0625 5.4e-130 bifunctional folylpolyglutamate synthase/dihydrofolate synthase; Psort location: Cytoplasmic, score: 7.50.
     
 0.970
fmt
methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family.
  
 
 0.932
fhs
KEGG: apv:Apar_0621 3.3e-178 Formate--tetrahydrofolate ligase K01938; Psort location: Cytoplasmic, score: 7.50.
  
 
 0.923
purN
Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
   
 
 0.917
purH
KEGG: apv:Apar_1330 2.9e-177 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase K00602; Psort location: Cytoplasmic, score: 7.50.
    
 0.916
KXG91370.1
Hypothetical protein; KEGG: ols:Olsu_0937 8.6e-36 glycine cleavage T protein (aminomethyl transferase); K00605 aminomethyltransferase; Psort location: Cytoplasmic, score: 7.50; Belongs to the GcvT family.
   
 
 0.814
KXG89406.1
KEGG: hdn:Hden_2415 4.5e-46 dihydropteroate synthase K00796; Psort location: Cytoplasmic, score: 7.50.
    
 0.800
KXG90764.1
Prephenate dehydratase; KEGG: ols:Olsu_0846 1.5e-111 Chorismate mutase K14170; Psort location: Cytoplasmic, score: 9.97.
     
 0.635
dut
dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family.
  
 
 0.602
Your Current Organism:
Atopobium vaginae
NCBI taxonomy Id: 82135
Other names: A. vaginae, ATCC BAA-55, ATCC:BAA 55, ATCC:BAA:55, CCUG 38953, CIP 106431, DSM 15829, NCTC 13935
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