node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
KXG89413.1 | KXG89458.1 | HMPREF3232_00980 | HMPREF3232_01026 | KEGG: ols:Olsu_0092 4.2e-75 hypoxanthine phosphoribosyltransferase K00760; Psort location: Cytoplasmic, score: 9.97; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.900 |
KXG89413.1 | KXG90593.1 | HMPREF3232_00980 | HMPREF3232_00521 | KEGG: ols:Olsu_0092 4.2e-75 hypoxanthine phosphoribosyltransferase K00760; Psort location: Cytoplasmic, score: 9.97; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Inosine 5-monophosphate dehydrogenase; KEGG: ols:Olsu_1037 1.1e-239 IMP dehydrogenase K00088; Psort location: Cytoplasmic, score: 7.50. | 0.946 |
KXG89413.1 | apt | HMPREF3232_00980 | HMPREF3232_00104 | KEGG: ols:Olsu_0092 4.2e-75 hypoxanthine phosphoribosyltransferase K00760; Psort location: Cytoplasmic, score: 9.97; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.951 |
KXG89413.1 | guaA | HMPREF3232_00980 | HMPREF3232_00294 | KEGG: ols:Olsu_0092 4.2e-75 hypoxanthine phosphoribosyltransferase K00760; Psort location: Cytoplasmic, score: 9.97; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | GMP synthase domain protein; Catalyzes the synthesis of GMP from XMP. | 0.964 |
KXG89413.1 | purA | HMPREF3232_00980 | HMPREF3232_01429 | KEGG: ols:Olsu_0092 4.2e-75 hypoxanthine phosphoribosyltransferase K00760; Psort location: Cytoplasmic, score: 9.97; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.952 |
KXG89413.1 | purH | HMPREF3232_00980 | HMPREF3232_01135 | KEGG: ols:Olsu_0092 4.2e-75 hypoxanthine phosphoribosyltransferase K00760; Psort location: Cytoplasmic, score: 9.97; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | KEGG: apv:Apar_1330 2.9e-177 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase K00602; Psort location: Cytoplasmic, score: 7.50. | 0.924 |
KXG89413.1 | tilS | HMPREF3232_00980 | HMPREF3232_00981 | KEGG: ols:Olsu_0092 4.2e-75 hypoxanthine phosphoribosyltransferase K00760; Psort location: Cytoplasmic, score: 9.97; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | tRNA(Ile)-lysidine synthetase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. | 0.950 |
KXG89458.1 | KXG89413.1 | HMPREF3232_01026 | HMPREF3232_00980 | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | KEGG: ols:Olsu_0092 4.2e-75 hypoxanthine phosphoribosyltransferase K00760; Psort location: Cytoplasmic, score: 9.97; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.900 |
KXG89458.1 | KXG90593.1 | HMPREF3232_01026 | HMPREF3232_00521 | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Inosine 5-monophosphate dehydrogenase; KEGG: ols:Olsu_1037 1.1e-239 IMP dehydrogenase K00088; Psort location: Cytoplasmic, score: 7.50. | 0.946 |
KXG89458.1 | apt | HMPREF3232_01026 | HMPREF3232_00104 | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.475 |
KXG89458.1 | guaA | HMPREF3232_01026 | HMPREF3232_00294 | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | GMP synthase domain protein; Catalyzes the synthesis of GMP from XMP. | 0.971 |
KXG89458.1 | purA | HMPREF3232_01026 | HMPREF3232_01429 | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.732 |
KXG89458.1 | purH | HMPREF3232_01026 | HMPREF3232_01135 | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | KEGG: apv:Apar_1330 2.9e-177 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase K00602; Psort location: Cytoplasmic, score: 7.50. | 0.493 |
KXG89458.1 | rph | HMPREF3232_01026 | HMPREF3232_01027 | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | tRNA nucleotidyltransferase; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. | 0.986 |
KXG89458.1 | tilS | HMPREF3232_01026 | HMPREF3232_00981 | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | tRNA(Ile)-lysidine synthetase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. | 0.470 |
KXG90535.1 | KXG90593.1 | HMPREF3232_00622 | HMPREF3232_00521 | CBS domain protein; KEGG: ols:Olsu_0365 4.8e-209 inorganic diphosphatase K15986; Psort location: Cytoplasmic, score: 9.97. | Inosine 5-monophosphate dehydrogenase; KEGG: ols:Olsu_1037 1.1e-239 IMP dehydrogenase K00088; Psort location: Cytoplasmic, score: 7.50. | 0.924 |
KXG90535.1 | guaA | HMPREF3232_00622 | HMPREF3232_00294 | CBS domain protein; KEGG: ols:Olsu_0365 4.8e-209 inorganic diphosphatase K15986; Psort location: Cytoplasmic, score: 9.97. | GMP synthase domain protein; Catalyzes the synthesis of GMP from XMP. | 0.872 |
KXG90535.1 | purA | HMPREF3232_00622 | HMPREF3232_01429 | CBS domain protein; KEGG: ols:Olsu_0365 4.8e-209 inorganic diphosphatase K15986; Psort location: Cytoplasmic, score: 9.97. | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.411 |
KXG90535.1 | rbsK-3 | HMPREF3232_00622 | HMPREF3232_01343 | CBS domain protein; KEGG: ols:Olsu_0365 4.8e-209 inorganic diphosphatase K15986; Psort location: Cytoplasmic, score: 9.97. | Putative ribokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. | 0.484 |
KXG90593.1 | KXG89413.1 | HMPREF3232_00521 | HMPREF3232_00980 | Inosine 5-monophosphate dehydrogenase; KEGG: ols:Olsu_1037 1.1e-239 IMP dehydrogenase K00088; Psort location: Cytoplasmic, score: 7.50. | KEGG: ols:Olsu_0092 4.2e-75 hypoxanthine phosphoribosyltransferase K00760; Psort location: Cytoplasmic, score: 9.97; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.946 |