STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KXG89416.1Hsp20/alpha crystallin family protein; KEGG: apb:SAR116_0129 2.8e-05 molecular chaperone K13993; Belongs to the small heat shock protein (HSP20) family. (142 aa)    
Predicted Functional Partners:
clpB
ATP-dependent chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.
  
 
 0.789
KXG88434.1
ATPase family protein; KEGG: crd:CRES_0206 1.7e-211 clpC; ATP-dependent Clp protease ATP-binding subunit K03696; Psort location: Cytoplasmic, score: 9.97; Belongs to the ClpA/ClpB family.
  
 
 0.789
dnaK
Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
 
 0.743
KXG89415.1
Hypothetical protein.
       0.697
htpG
Hsp90 protein; Molecular chaperone. Has ATPase activity.
  
 
 0.689
grpE
Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...]
  
  
 0.633
KXG90301.1
PASTA domain protein; KEGG: elm:ELI_3323 2.4e-15 hypothetical protein; K08884 serine/threonine protein kinase, bacterial.
   
 
 0.608
KXG88482.1
Kinase domain protein; KEGG: ols:Olsu_1758 1.4e-209 serine/threonine protein kinase; K08884 serine/threonine protein kinase, bacterial; Psort location: CytoplasmicMembrane, score: 9.99.
   
 
 0.608
KXG91323.1
DnaJ domain protein; KEGG: apb:SAR116_1614 2.3e-28 DnaJ family molecular chaperone K03686; Psort location: Cytoplasmic, score: 9.97.
  
 
 0.595
dnaJ
Putative chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions betwee [...]
  
 
 0.595
Your Current Organism:
Atopobium vaginae
NCBI taxonomy Id: 82135
Other names: A. vaginae, ATCC BAA-55, ATCC:BAA 55, ATCC:BAA:55, CCUG 38953, CIP 106431, DSM 15829, NCTC 13935
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.