hutI protein (Paracoccus pantotrophus) - STRING interaction network

Nodes:

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second shell of interactors

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filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

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[Homology]

Score

hutI

Imidazolonepropionase. (400 aa)

Predicted Functional Partners:

hutU

0.999

hutH

0.999

HutG

0.991

SFO73894.1

0.988

SFO73909.1

0.910

SFO52102.1

0.801

SFO73797.1

0.781

SFO73817.1

0.780

SFO91845.1

0.770

SFO37158.1

0.742

Your Current Organism:

Paracoccus pantotrophus

NCBI taxonomy Id: 82367
Other names: ATCC 35512, DSM 2944, JCM 21485, LMD 82.5, NBRC 102493, NCCB 82005, P. pantotrophus, Thiosphaera pantotropha, strain GB 17, strain GB17

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HutG	SFO52102.1	SAMN04244567_02916	SAMN04244567_02088	Formiminoglutamase.	Hypothetical protein.	0.619
HutG	SFO73797.1	SAMN04244567_02916	SAMN04244567_02914	Formiminoglutamase.	butyryl-CoA dehydrogenase.	0.773
HutG	SFO73817.1	SAMN04244567_02916	SAMN04244567_02915	Formiminoglutamase.	Crotonobetainyl-CoA:carnitine CoA-transferase CaiB; Belongs to the CoA-transferase III family.	0.773
HutG	SFO73894.1	SAMN04244567_02916	SAMN04244567_02919	Formiminoglutamase.	Amidohydrolase family protein.	0.990
HutG	SFO73909.1	SAMN04244567_02916	SAMN04244567_02920	Formiminoglutamase.	GntR family transcriptional regulator, histidine utilization repressor.	0.894
HutG	SFO91845.1	SAMN04244567_02916	SAMN04244567_03409	Formiminoglutamase.	GntR family transcriptional regulator, histidine utilization repressor.	0.727
HutG	hutH	SAMN04244567_02916	SAMN04244567_02917	Formiminoglutamase.	Histidine ammonia-lyase.	0.951
HutG	hutI	SAMN04244567_02916	SAMN04244567_02918	Formiminoglutamase.	Imidazolonepropionase.	0.991
HutG	hutU	SAMN04244567_02916	SAMN04244567_02913	Formiminoglutamase.	Urocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate.	0.956
SFO37158.1	SFO52102.1	SAMN04244567_01518	SAMN04244567_02088	N-formylglutamate amidohydrolase.	Hypothetical protein.	0.420
SFO37158.1	SFO73894.1	SAMN04244567_01518	SAMN04244567_02919	N-formylglutamate amidohydrolase.	Amidohydrolase family protein.	0.659
SFO37158.1	hutH	SAMN04244567_01518	SAMN04244567_02917	N-formylglutamate amidohydrolase.	Histidine ammonia-lyase.	0.493
SFO37158.1	hutI	SAMN04244567_01518	SAMN04244567_02918	N-formylglutamate amidohydrolase.	Imidazolonepropionase.	0.742
SFO37158.1	hutU	SAMN04244567_01518	SAMN04244567_02913	N-formylglutamate amidohydrolase.	Urocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate.	0.529
SFO52102.1	HutG	SAMN04244567_02088	SAMN04244567_02916	Hypothetical protein.	Formiminoglutamase.	0.619
SFO52102.1	SFO37158.1	SAMN04244567_02088	SAMN04244567_01518	Hypothetical protein.	N-formylglutamate amidohydrolase.	0.420
SFO52102.1	SFO73894.1	SAMN04244567_02088	SAMN04244567_02919	Hypothetical protein.	Amidohydrolase family protein.	0.436
SFO52102.1	SFO73909.1	SAMN04244567_02088	SAMN04244567_02920	Hypothetical protein.	GntR family transcriptional regulator, histidine utilization repressor.	0.664
SFO52102.1	SFO91845.1	SAMN04244567_02088	SAMN04244567_03409	Hypothetical protein.	GntR family transcriptional regulator, histidine utilization repressor.	0.618
SFO52102.1	hutH	SAMN04244567_02088	SAMN04244567_02917	Hypothetical protein.	Histidine ammonia-lyase.	0.798

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

54

average node degree:

9.82

avg. local clustering coefficient:

0.982

expected number of edges:

16

PPI enrichment p-value:

6.08e-14

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006084

acetyl-CoA metabolic process

4 of 7

2.32

2.64

7.88e-06

GO:0006086

acetyl-CoA biosynthetic process from pyruvate

3 of 3

2.56

2.41

3.25e-05

GO:0045454

Cell redox homeostasis

3 of 5

2.34

2.22

5.87e-05

GO:0006090

Pyruvate metabolic process

4 of 21

1.84

2.07

3.25e-05

GO:0009150

Purine ribonucleotide metabolic process

6 of 60

1.56

1.95

7.88e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004148

Dihydrolipoyl dehydrogenase activity

3 of 3

2.56

2.0

0.00020

GO:0016624

Oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor

3 of 4

2.44

1.98

0.00020

GO:0004739

Pyruvate dehydrogenase (acetyl-transferring) activity

2 of 2

2.56

1.32

0.0039

GO:0050660

Flavin adenine dinucleotide binding

3 of 28

1.59

1.08

0.0048

GO:0016491

Oxidoreductase activity

7 of 363

0.85

0.67

0.0020

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:1990204

Oxidoreductase complex

3 of 11

2.0

1.62

0.00062

GO:0005622

Intracellular anatomical structure

9 of 1237

0.42

0.29

0.0316

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:934

Dehydrogenase, E1 component, and e3 binding domain

10 of 11

2.52

9.3

1.13e-20

CL:932

Citrate cycle (TCA cycle), and Glycine catabolic process

11 of 28

2.16

7.65

1.13e-20

CL:946

acetyl-CoA biosynthetic process from pyruvate, and Dihydrolipoamide dehydrogenase

5 of 5

2.56

4.57

1.47e-09

CL:936

Dehydrogenase E1 component, and e3 binding domain

4 of 5

2.47

3.34

3.76e-07

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00020

Citrate cycle (TCA cycle)

8 of 24

2.09

5.35

1.24e-13

map00310

Lysine degradation

5 of 14

2.12

3.65

1.48e-08

map00380

Tryptophan metabolism

5 of 15

2.09

3.59

1.64e-08

map00620

Pyruvate metabolism

7 of 42

1.78

3.5

3.31e-10

map00010

Glycolysis / Gluconeogenesis

6 of 34

1.81

3.19

8.94e-09

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1222499

Latent infection - Other responses of Mtb to phagocytosis

3 of 50

1.34

0.87

0.0092

MAP-9635486

Infection with Mycobacterium tuberculosis

3 of 84

1.12

0.67

0.0198

MAP-5663205

Infectious disease

3 of 89

1.09

0.65

0.0198

MAP-1643685

Disease

3 of 98

1.05

0.63

0.0198

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:1990204

Oxidoreductase complex

4 of 24

1.78

1.74

0.00018

GOCC:0045254

Pyruvate dehydrogenase complex

2 of 2

2.56

1.21

0.0061

GOCC:0005622

Intracellular

10 of 1237

0.47

0.36

0.0062

GOCC:0005737

Cytoplasm

8 of 858

0.53

0.35

0.0293

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0670

Pyruvate

4 of 13

2.05

2.37

1.45e-05

KW-0450

Lipoyl

3 of 4

2.44

2.27

5.42e-05

KW-0274

FAD

3 of 19

1.76

1.35

0.0016

KW-0786

Thiamine pyrophosphate

2 of 6

2.09

1.19

0.0055

KW-0676

Redox-active center

2 of 7

2.02

1.15

0.0062

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02852

Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain

3 of 3

2.56

2.04

0.00017

PF02817

e3 binding domain

3 of 3

2.56

2.04

0.00017

PF00198

2-oxoacid dehydrogenases acyltransferase (catalytic domain)

3 of 3

2.56

2.04

0.00017

PF02780

Transketolase, C-terminal domain

3 of 4

2.44

2.01

0.00017

PF00364

Biotin-requiring enzyme

3 of 5

2.34

1.99

0.00017

(more ...)

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR029061

Thiamin diphosphate-binding fold

4 of 9

2.21

2.3

3.14e-05

IPR036625

E3-binding domain superfamily

3 of 3

2.56

1.98

0.00022

IPR023213

Chloramphenicol acetyltransferase-like domain superfamily

3 of 3

2.56

1.98

0.00022

IPR004167

Peripheral subunit-binding domain

3 of 3

2.56

1.98

0.00022

IPR004099

Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain

3 of 3

2.56

1.98

0.00022

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00861

Transketolase, pyrimidine binding domain

3 of 6

2.26

1.98

0.00016

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