STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dnaAChromosomal replication initiator protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. (442 aa)    
Predicted Functional Partners:
pycB
Pyruvate carboxylase, subunit B; Pfam matches to PF02436.14 PYC_OADA, and to PF00364.18 Biotin_lipoyl, and to PF00682.15 HMGL-like; draft locus tag CAMGR0001_0046.
 
      0.900
dnaN
DNA polymerase III, beta subunit; Pfam matches to PF02767.12 DNA_pol3_beta_2, and to PF00712.15 DNA_pol3_beta, and to PF02768.11 DNA_pol3_beta_3; draft locus tag CAMGR0001_0277.
 
    0.802
AKT93538.1
Putative PAS sensor-containing diguanylate phosphodiesterase; Pfam matches to PF00563.16 EAL, and to PF00989.20 PAS; draft locus tag CAMGR0001_0214.
  
 
 0.588
AKT91875.1
Two-component system response regulator; Pfam matches to PF00072.20 Response_reg, and to PF00486.24 Trans_reg_C; draft locus tag CAMGR0001_2567.
  
   0.543
AKT91482.1
Diguanylate cyclase/phosphodiesterase; Pfam matches to PF00563.16 EAL, and to PF00990.17 GGDEF; draft locus tag CAMGR0001_0279.
  
  
 0.532
AKT93472.1
Two-component system response regulator; Pfam match to PF00072.20 Response_reg; draft locus tag CAMGR0001_2304.
  
   0.500
AKT92516.1
Two-component system response regulator; Pfam matches to PF00072.20 Response_reg, and to PF00486.24 Trans_reg_C; draft locus tag CAMGR0001_1035.
  
   0.483
AKT91484.1
HD family hydrolase, possible ComGF family competence protein; Pfam match to PF13023.2 HD_3; draft locus tag CAMGR0001_0281.
   
   0.482
gyrB
DNA gyrase, subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
     
 0.478
racR
Two-component system response regulator; Pfam matches to PF00072.20 Response_reg, and to PF00486.24 Trans_reg_C; draft locus tag CAMGR0001_0699.
  
   0.476
Your Current Organism:
Campylobacter gracilis
NCBI taxonomy Id: 824
Other names: ATCC 33236, Bacteroides gracilis, C. gracilis, CCUG 27720, DSM 19528, JCM 8538, NCTC 12738
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.