STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
purDPhosphoribosylamine-glycine ligase; Pfam matches to PF01071.15 GARS_A, and to PF02844.11 GARS_N, and to PF02843.12 GARS_C; draft locus tag CAMGR0001_0081; Belongs to the GARS family. (418 aa)    
Predicted Functional Partners:
purN
Phosphoribosylglycinamide formyltransferase 1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
 
 0.999
purM
Phosphoribosylformylglycinamide cyclo-ligase; Pfam matches to PF02769.18 AIRS_C, and to PF00586.20 AIRS; draft locus tag CAMGR0001_0662.
  
 0.997
purE
5-aminoimidazole ribonucleotide (AIR) carboxylase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).
  
 0.997
purF
Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
 
 0.995
purQ
Phosphoribosylformylglycinamidine synthase PurLQS, glutaminase subunit PurQ; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and [...]
  
 0.993
purH
AICAR transformylase / IMP cyclohydrolase; Bifunctional; Pfam matches to PF01808.14 AICARFT_IMPCHas, and to PF02142.18 MGS; draft locus tag CAMGR0001_1920.
 
 
 0.951
purL
Phosphoribosylformylglycinamidine synthase PurLQS, PurL subunit; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is [...]
  
 0.925
purC
Phosphoribosylaminoimidazole-succinocarboxamide synthase; Pfam match to PF01259.14 SAICAR_synt; draft locus tag CAMGR0001_2341; Belongs to the SAICAR synthetase family.
  
 
 0.915
purB
Pfam matches to PF00206.16 Lyase_1, and to PF10397.5 ADSL_C; draft locus tag CAMGR0001_0342; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
  
 
 0.912
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
  
  
 0.907
Your Current Organism:
Campylobacter gracilis
NCBI taxonomy Id: 824
Other names: ATCC 33236, Bacteroides gracilis, C. gracilis, CCUG 27720, DSM 19528, JCM 8538, NCTC 12738
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.