STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
topADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (743 aa)    
Predicted Functional Partners:
leuS
leucyl-tRNA synthetase; Pfam matches to PF13603.2 tRNA-synt_1_2, and to PF00133.18 tRNA-synt_1, and to PF09334.7 tRNA-synt_1g; draft locus tag CAMGR0001_1526; Belongs to the class-I aminoacyl-tRNA synthetase family.
   
 
 0.977
por
Pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Pfam matches to PF01855.15 POR_N, and to PF01558.14 POR, and to PF10371.5 EKR, and to PF12838.3 Fer4_7, and to PF02775.17 TPP_enzyme_C; draft locus tag CAMGR0001_2171.
  
   0.969
ssb-2
Single-stranded DNA-binding protein; Pfam match to PF00436.21 SSB; draft locus tag CAMGR0001_2141.
  
 
 0.933
ssb
Single-stranded DNA binding protein; Pfam match to PF00436.21 SSB; draft locus tag CAMGR0001_1987.
  
 
 0.933
polA
DNA polymerase I, 5' --> 3' polymerase, 5' --> 3' and 3' --> 5' exonuclease; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
 
 0.897
rpoA
DNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
   
 
 0.833
recA
Recombinase; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 0.820
AKT91577.1
Metallophosphatase; Pfam match to PF12850.3 Metallophos_2; draft locus tag CAMGR0001_0071.
       0.804
dcd
dCTP deaminase; Catalyzes the deamination of dCTP to dUTP.
       0.804
AKT91576.1
Na+/H+ exchanger family protein; Pfam match to PF00999.17 Na_H_Exchanger; draft locus tag CAMGR0001_0072.
       0.803
Your Current Organism:
Campylobacter gracilis
NCBI taxonomy Id: 824
Other names: ATCC 33236, Bacteroides gracilis, C. gracilis, CCUG 27720, DSM 19528, JCM 8538, NCTC 12738
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.