STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nrdBAerobic ribonucleoside-diphosphate reductase Ia, B2 protein subunit NrdB; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (340 aa)    
Predicted Functional Partners:
nrdA
Aerobic ribonucleoside-diphosphate reductase Ia, B1 protein subunit NrdA; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
 
 0.999
tmk
dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.
   
 
 0.923
adk
Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.
     
 0.922
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
     
 0.911
pykF
Pyruvate kinase I; Pfam matches to PF00224.17 PK, and to PF02887.12 PK_C; draft locus tag CAMGR0001_1206; Belongs to the pyruvate kinase family.
     
 0.910
gmk
Deoxyguanylate kinase / guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
     
 0.905
spoT
ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3' pyrophosphohydrolase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.
     
  0.900
pcm
L-isoaspartate protein carboxylmethyltransferase, type II; Pfam match to PF01135.15 PCMT; draft locus tag CAMGR0001_1863.
       0.800
AKT91968.1
Hypothetical protein; Draft locus tag CAMGR0001_1864.
       0.773
nrdD2
Anaerobic ribonucleoside triphosphate reductase; Pfam matches to PF13597.2 NRDD, and to PF03477.12 ATP-cone; draft locus tag CAMGR0001_1869.
  
  
 0.639
Your Current Organism:
Campylobacter gracilis
NCBI taxonomy Id: 824
Other names: ATCC 33236, Bacteroides gracilis, C. gracilis, CCUG 27720, DSM 19528, JCM 8538, NCTC 12738
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