STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
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[Homology]
Score
ilvCAcetohydroxy acid isomeroreductase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (340 aa)    
Predicted Functional Partners:
ilvD
Dihydroxyacid dehydratase; Pfam match to PF00920.17 ILVD_EDD; draft locus tag CAMGR0001_0185; Belongs to the IlvD/Edd family.
 
 
 0.995
ilvH
Acetolactate synthase III, valine-sensitive, regulatory (small) subunit; Pfam matches to PF01842.21 ACT, and to PF10369.5 ALS_ss_C; draft locus tag CAMGR0001_1023.
 
 
 0.994
ilvI
Acetolactate synthase III, valine-sensitive, catalytic (large) subunit; Pfam matches to PF02776.14 TPP_enzyme_N, and to PF02775.17 TPP_enzyme_C, and to PF00205.18 TPP_enzyme_M; draft locus tag CAMGR0001_1024.
 
 
 0.984
AKT93337.1
Thiamine pyrophosphate binding domain protein; Pfam matches to PF02776.14 TPP_enzyme_N, and to PF00205.18 TPP_enzyme_M, and to PF02775.17 TPP_enzyme_C; draft locus tag CAMGR0001_0394.
 
 
 0.975
leuC
Isopropylmalate isomerase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
  
  
 0.898
leuD
Isopropylmalate isomerase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily.
  
  
 0.897
leuA
2-isopropylmalate synthase, bacterial type; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
  
  
 0.896
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
  
  
 0.895
AKT92307.1
Divergent polysaccharide deacetylase; Pfam match to PF04748.9 Polysacc_deac_2; draft locus tag CAMGR0001_1329.
       0.772
dprA
DNA protecting protein DprA; Pfam match to PF02481.11 DNA_processg_A; draft locus tag CAMGR0001_1328.
       0.772
Your Current Organism:
Campylobacter gracilis
NCBI taxonomy Id: 824
Other names: ATCC 33236, Bacteroides gracilis, C. gracilis, CCUG 27720, DSM 19528, JCM 8538, NCTC 12738
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