STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hslUHeat shock protein HslVU, ATPase subunit; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. (438 aa)    
Predicted Functional Partners:
hslV
Heat shock protein HslVU, ATP-dependent protease subunit; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.
 
 0.999
dnaJ
DnaK system heat shock co-chaperone; Pfam matches to PF01556.14 DnaJ_C, and to PF00226.27 DnaJ, and to PF00684.15 DnaJ_CXXCXGXG; draft locus tags CAMGR0001_0696 and CAMGR0001_0697.
   
 
 0.885
grpE
DnaK system nucleotide exchange factor GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Se [...]
   
  
 0.878
groEL
60 kD chaperonin (cpn60); Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
   
  
 0.865
groES
10 kD chaperonin (cpn10); Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.
   
  
 0.847
htpG
Chaperone protein HtpG; Molecular chaperone. Has ATPase activity.
   
  
 0.841
lon
DNA-binding, ATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
  
  
 0.836
rplI
50S ribosomal protein L9; Binds to the 23S rRNA.
       0.800
dnaK
DnaK system heat shock chaperone; Acts as a chaperone; Belongs to the heat shock protein 70 family.
   
  
 0.711
AKT92688.1
Ribosome-associated heat shock protein (S4 domain); Pfam match to PF01479.21 S4; draft locus tag CAMGR0001_0768.
  
  
 0.699
Your Current Organism:
Campylobacter gracilis
NCBI taxonomy Id: 824
Other names: ATCC 33236, Bacteroides gracilis, C. gracilis, CCUG 27720, DSM 19528, JCM 8538, NCTC 12738
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