STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
clpBATP-dependent Clp protease, ATP-binding subunit; Pfam matches to PF07724.10 AAA_2, and to PF10431.5 ClpB_D2-small, and to PF00004.25 AAA, and to PF02861.16 Clp_N; draft locus tag CAMGR0001_2343; Belongs to the ClpA/ClpB family. (869 aa)    
Predicted Functional Partners:
dnaK
DnaK system heat shock chaperone; Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
 
 0.970
clpP
ATP-dependent ClpAP/ClpXP protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.
   
 
 0.916
grpE
DnaK system nucleotide exchange factor GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Se [...]
  
 
 0.804
clpS
ATP-dependent Clp protease adaptor protein ClpS; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family.
  
 
 0.779
htpG
Chaperone protein HtpG; Molecular chaperone. Has ATPase activity.
  
 
 0.668
cbpA
Co-chaperone-curved DNA binding protein A; Pfam matches to PF00226.27 DnaJ, and to PF01556.14 DnaJ_C; draft locus tag CAMGR0001_0712.
  
 
 0.624
dnaJ
DnaK system heat shock co-chaperone; Pfam matches to PF01556.14 DnaJ_C, and to PF00226.27 DnaJ, and to PF00684.15 DnaJ_CXXCXGXG; draft locus tags CAMGR0001_0696 and CAMGR0001_0697.
  
 
 0.617
groES
10 kD chaperonin (cpn10); Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.
  
 
 0.605
lon
DNA-binding, ATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
   
 
 0.603
ctpA
Carboxyl-terminal protease family protein; Pfam matches to PF03572.14 Peptidase_S41, and to PF13180.2 PDZ_2; draft locus tag CAMGR0001_2342; Belongs to the peptidase S41A family.
     
 0.601
Your Current Organism:
Campylobacter gracilis
NCBI taxonomy Id: 824
Other names: ATCC 33236, Bacteroides gracilis, C. gracilis, CCUG 27720, DSM 19528, JCM 8538, NCTC 12738
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.