STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
leuA2-isopropylmalate synthase, bacterial type; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (504 aa)    
Predicted Functional Partners:
leuC
Isopropylmalate isomerase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 
 
 0.990
leuD
Isopropylmalate isomerase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily.
  
 
 0.989
ilvD
Dihydroxyacid dehydratase; Pfam match to PF00920.17 ILVD_EDD; draft locus tag CAMGR0001_0185; Belongs to the IlvD/Edd family.
 
 
 0.988
ilvE
Branched-chain amino-acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
  
 0.985
por
Pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Pfam matches to PF01855.15 POR_N, and to PF01558.14 POR, and to PF10371.5 EKR, and to PF12838.3 Fer4_7, and to PF02775.17 TPP_enzyme_C; draft locus tag CAMGR0001_2171.
  
 
 0.961
ilvH
Acetolactate synthase III, valine-sensitive, regulatory (small) subunit; Pfam matches to PF01842.21 ACT, and to PF10369.5 ALS_ss_C; draft locus tag CAMGR0001_1023.
  
 
 0.947
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
 
 
 0.942
pycA
Pyruvate carboxylase, subunit A; Pfam matches to PF02786.13 CPSase_L_D2, and to PF00289.18 CPSase_L_chain, and to PF02785.15 Biotin_carb_C; draft locus tag CAMGR0001_0759.
  
 
 0.924
pta
Phosphate acetyltransferase; Bifunctional; Pfam match to PF01515.15 PTA_PTB; draft locus tag CAMGR0001_1027.
     
 0.910
oorA
2-oxoglutarate:acceptor oxidoreductase, alpha subunit; Pfam match to PF01855.15 POR_N; draft locus tag CAMGR0001_0940.
   
 
 0.910
Your Current Organism:
Campylobacter gracilis
NCBI taxonomy Id: 824
Other names: ATCC 33236, Bacteroides gracilis, C. gracilis, CCUG 27720, DSM 19528, JCM 8538, NCTC 12738
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.