STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hisHImidazole glycerol phosphate synthase HisFH, HisH subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (234 aa)    
Predicted Functional Partners:
hisF
Imidazole glycerol phosphate synthase HisFH, HisF subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
 0.999
hisIE
phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP pyrophosphatase; Bifunctional; Pfam matches to PF01502.14 PRA-CH, and to PF01503.13 PRA-PH; draft locus tag CAMGR0001_0015; In the N-terminal section; belongs to the PRA-CH family.
 
  
 0.999
hisA
N-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'-phosphoribosyl)-4-imidazolecarboxamide isomerase; Pfam match to PF00977.17 His_biosynth; draft locus tag CAMGR0001_2006.
 
 
 0.999
hisB
Imidazoleglycerol-phosphate dehydratase; Pfam match to PF00475.14 IGPD; draft locus tag CAMGR0001_2366.
 
 
 0.997
hisD
Histidinal dehydrogenase / histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
 
  
 0.975
hisG(S)
ATP phosphoribosyltransferase HisG(S)Z, hetero-octameric short form, catalytic subunit; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
 
  
 0.974
hisC
Histidinol-phosphate aminotransferase; Pfam match to PF00155.17 Aminotran_1_2; draft locus tag CAMGR0001_2538; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
 
  
 0.931
AKT92188.1
Histidinol-phosphate / aromatic aminotransferase; Pfam match to PF00155.17 Aminotran_1_2; draft locus tag CAMGR0001_1510.
 
  
 0.930
purH
AICAR transformylase / IMP cyclohydrolase; Bifunctional; Pfam matches to PF01808.14 AICARFT_IMPCHas, and to PF02142.18 MGS; draft locus tag CAMGR0001_1920.
    
 0.841
pglE
UDP-4-amino-4, 6-dideoxy-alpha-D-N-acetyl-D-glucosamine transaminase; Pfam match to PF01041.13 DegT_DnrJ_EryC1; draft locus tag CAMGR0001_2009; Belongs to the DegT/DnrJ/EryC1 family.
  
    0.814
Your Current Organism:
Campylobacter gracilis
NCBI taxonomy Id: 824
Other names: ATCC 33236, Bacteroides gracilis, C. gracilis, CCUG 27720, DSM 19528, JCM 8538, NCTC 12738
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.