STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ribAGTP cyclohydrolase II; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family. (186 aa)    
Predicted Functional Partners:
ribAB
Bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase / GTP cyclohydrolase II protein; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. Belongs to the DHBP synthase family.
  
 0.997
ribD
Riboflavin biosynthesis protein RibD; Bifunctional; Pfam match to PF00383.18 dCMP_cyt_deam_1; draft locus tag CAMGR0001_1613.
 
 0.994
ribE
6,7-dimethyl-8-ribityllumazine synthase (riboflavin synthase, alpha subunit); Pfam matches to PF00677.13 Lum_binding, and to PF00677.13 Lum_binding; draft locus tag CAMGR0001_1356.
 
 0.966
folE
Pfam match to PF01227.18 GTP_cyclohydroI; draft locus tag CAMGR0001_0103.
   
 
 0.923
ribH
6,7-dimethyl-8-ribityllumazine synthase (riboflavin synthase, beta subunit); Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
 
  
 0.905
moaA
Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate.
     
  0.900
AKT93141.1
Putative protein (NIF3 domain); Pfam match to PF01784.14 NIF3; draft locus tag CAMGR0001_2868.
     
  0.900
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
   
 0.828
spoT
ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3' pyrophosphohydrolase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.
  
 
  0.803
nrdD2
Anaerobic ribonucleoside triphosphate reductase; Pfam matches to PF13597.2 NRDD, and to PF03477.12 ATP-cone; draft locus tag CAMGR0001_1869.
     
  0.800
Your Current Organism:
Campylobacter gracilis
NCBI taxonomy Id: 824
Other names: ATCC 33236, Bacteroides gracilis, C. gracilis, CCUG 27720, DSM 19528, JCM 8538, NCTC 12738
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