STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
uvrBUvrABC nucleotide excision repair complex, subunit UvrB; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found [...] (658 aa)    
Predicted Functional Partners:
uvrA
UvrABC nucleotide excision repair complex, subunit UvrA; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.
 
 0.999
uvrC
UvrABC nucleotide excision repair complex, subunit UvrC; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
 0.994
AKT92402.1
UvrD/REP family helicase; Pfam matches to PF13361.2 UvrD_C, and to PF00580.17 UvrD-helicase, and to PF00580.17 UvrD-helicase; draft locus tag CAMGR0001_1196.
  
 
 0.808
rep
ATP-dependent DNA helicase; Pfam matches to PF13361.2 UvrD_C, and to PF00580.17 UvrD-helicase, and to PF00580.17 UvrD-helicase; draft locus tag CAMGR0001_0865.
  
 
 0.768
polA
DNA polymerase I, 5' --> 3' polymerase, 5' --> 3' and 3' --> 5' exonuclease; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
     
 0.630
AKT93215.1
Hypothetical protein; Draft locus tag CAMGR0001_0553.
       0.607
pheT
phenylalanyl-tRNA synthetase, beta subunit; Pfam matches to PF01588.16 tRNA_bind, and to PF03147.10 FDX-ACB, and to PF03484.11 B5, and to PF03483.13 B3_4; draft locus tag CAMGR0001_2845; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
 
   
 0.596
AKT93213.1
Hypothetical protein; Draft locus tag CAMGR0001_0555.
       0.571
AKT93214.1
Hypothetical protein; Draft locus tag CAMGR0001_0554.
       0.562
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
     
 0.535
Your Current Organism:
Campylobacter gracilis
NCBI taxonomy Id: 824
Other names: ATCC 33236, Bacteroides gracilis, C. gracilis, CCUG 27720, DSM 19528, JCM 8538, NCTC 12738
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.