STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
thiEThiamine phosphate synthase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (204 aa)    
Predicted Functional Partners:
thiD
Hydroxymethylpyrimidine kinase / phosphohydroxymethylpyrimidine kinase; Bifunctional; Pfam matches to PF08543.8 Phos_pyr_kin, and to PF08543.8 Phos_pyr_kin; draft locus tag CAMGR0001_0138.
 
 0.998
thiL
Thiamine monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family.
    
 0.912
thiG
ThiGH complex, thiazole synthase subunit ThiG; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
 
 
 0.909
bacA
Undecaprenyl pyrophosphate phosphatase; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family.
       0.800
AKT93289.1
Hypothetical protein; Draft locus tag CAMGR0001_0461.
       0.787
thiC
HMP-P synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
 
  
 0.714
opgE
Phosphoethanolamine transferase; Pfam match to PF00884.19 Sulfatase; draft locus tag CAMGR0001_0458.
       0.701
thiH
ThiGH complex, tyrosine lyase subunit ThiH; Pfam match to PF06968.9 BATS; draft locus tag CAMGR0001_0586.
  
  
 0.694
hemL
Glutamate-1-semialdehyde aminotransferase; Pfam match to PF00202.17 Aminotran_3; draft locus tag CAMGR0001_0751.
    
 0.629
AKT93287.1
Amino acid ABC transporter, ATP-binding protein; Pfam match to PF00005.23 ABC_tran; draft locus tag CAMGR0001_0463.
       0.626
Your Current Organism:
Campylobacter gracilis
NCBI taxonomy Id: 824
Other names: ATCC 33236, Bacteroides gracilis, C. gracilis, CCUG 27720, DSM 19528, JCM 8538, NCTC 12738
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