STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
ispH4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (414 aa)    
Predicted Functional Partners:
ispG
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family.
 
 
 0.991
AFY70531.1
PFAM: NUDIX domain; TIGRFAM: isopentenyl-diphosphate delta-isomerase, type 1; COGs: COG1443 Isopentenyldiphosphate isomerase; HAMAP: Isopentenyl-diphosphate delta-isomerase, type 1; InterPro IPR011876:IPR000086; KEGG: eba:p2A143 putative isopentenyl-diphosphate delta-isomerase; PFAM: NUDIX hydrolase domain; PRIAM: Isopentenyl-diphosphate Delta-isomerase; SPTR: Isopentenyl-diphosphate Delta-isomerase 2; TIGRFAM: Isopentenyl-diphosphate delta-isomerase, type 1.
 
   
 0.973
AFY71721.1
Farnesyl-diphosphate synthase; PFAM: Polyprenyl synthetase; COGs: COG0142 Geranylgeranyl pyrophosphate synthase; InterPro IPR000092; KEGG: cyn:Cyan7425_0972 polyprenyl synthetase; PFAM: Polyprenyl synthetase; SPTR: Polyprenyl synthetase superfamily; Belongs to the FPP/GGPP synthase family.
 
 
 0.938
AFY69071.1
SSU ribosomal protein S1P; PFAM: S1 RNA binding domain; COGs: COG0539 Ribosomal protein S1; InterPro IPR003029:IPR022967; KEGG: ava:Ava_1505 30S ribosomal protein S1; PFAM: Ribosomal protein S1, RNA-binding domain; SMART: RNA-binding domain, S1; SPTR: 30S ribosomal protein S1.
 
  
 0.906
AFY70717.1
PFAM: S1 RNA binding domain; COGs: COG0539 Ribosomal protein S1; InterPro IPR003029:IPR022967; KEGG: amr:AM1_1453 30S ribosomal protein S1; PFAM: Ribosomal protein S1, RNA-binding domain; SMART: RNA-binding domain, S1; SPTR: 30S ribosomal protein S1.
 
  
 0.906
dxr
1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family.
 
   
 0.899
ispF
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
 
   
 0.894
ispD
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
 
   
 0.875
ispE
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
 
   
 0.814
dxs
1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily.
 
  
 0.765
Your Current Organism:
Pseudanabaena sp. PCC7367
NCBI taxonomy Id: 82654
Other names: Calotaxis gracile PCC 7367, P. sp. PCC 7367, Pseudanabaena PCC7367, Pseudanabaena sp. PCC 7367
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