node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AKJ42980.1 | cyaY | QQ39_13650 | QQ39_17620 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Frataxin-like protein; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. | 0.703 |
AKJ42980.1 | fdx | QQ39_13650 | QQ39_13655 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 2Fe-2S ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.992 |
AKJ42980.1 | hscA | QQ39_13650 | QQ39_13660 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Chaperone protein HscA; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. Involved in the maturation of IscU. | 0.941 |
AKJ42980.1 | hscB | QQ39_13650 | QQ39_13665 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Co-chaperone HscB; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | 0.981 |
AKJ42980.1 | iscA | QQ39_13650 | QQ39_13670 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Iron-sulfur cluster assembly protein; Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system TrxA/TrxB. | 0.838 |
AKJ42980.1 | iscR | QQ39_13650 | QQ39_13685 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Transcriptional regulator; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. | 0.545 |
AKJ42980.1 | iscS | QQ39_13650 | QQ39_13680 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. | 0.852 |
AKJ42980.1 | nfuA | QQ39_13650 | QQ39_01290 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Fe/S biogenesis protein NfuA; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. | 0.613 |
AKJ42980.1 | nifU | QQ39_13650 | QQ39_13675 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Scaffolding protein; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | 0.887 |
AKJ42980.1 | pepB | QQ39_13650 | QQ39_13645 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Aminopeptidase B; Probably plays an important role in intracellular peptide degradation. | 0.703 |
cyaY | AKJ42980.1 | QQ39_17620 | QQ39_13650 | Frataxin-like protein; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.703 |
cyaY | fdx | QQ39_17620 | QQ39_13655 | Frataxin-like protein; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. | 2Fe-2S ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.883 |
cyaY | hscA | QQ39_17620 | QQ39_13660 | Frataxin-like protein; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. | Chaperone protein HscA; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. Involved in the maturation of IscU. | 0.741 |
cyaY | hscB | QQ39_17620 | QQ39_13665 | Frataxin-like protein; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. | Co-chaperone HscB; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | 0.817 |
cyaY | iscA | QQ39_17620 | QQ39_13670 | Frataxin-like protein; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. | Iron-sulfur cluster assembly protein; Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system TrxA/TrxB. | 0.578 |
cyaY | iscS | QQ39_17620 | QQ39_13680 | Frataxin-like protein; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. | Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. | 0.983 |
cyaY | nfuA | QQ39_17620 | QQ39_01290 | Frataxin-like protein; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. | Fe/S biogenesis protein NfuA; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. | 0.617 |
cyaY | nifU | QQ39_17620 | QQ39_13675 | Frataxin-like protein; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. | Scaffolding protein; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | 0.989 |
fdx | AKJ42980.1 | QQ39_13655 | QQ39_13650 | 2Fe-2S ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.992 |
fdx | cyaY | QQ39_13655 | QQ39_17620 | 2Fe-2S ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. | Frataxin-like protein; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. | 0.883 |