| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AMS38945.1 | AMS42316.1 | AA2016_0002 | AA2016_3394 | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Single-stranded DNA exonuclease; Pfam:pfam01368 DHH family. | 0.733 |
| AMS38945.1 | AMS43023.1 | AA2016_0002 | AA2016_4106 | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | ATP-dependent DNA helicase RecQ; Pfam:pfam09382 RQC domain. | 0.860 |
| AMS38945.1 | mutL | AA2016_0002 | AA2016_4188 | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | 0.955 |
| AMS38945.1 | mutS | AA2016_0002 | AA2016_0524 | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. | 0.950 |
| AMS38945.1 | polA | AA2016_0002 | AA2016_0291 | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.995 |
| AMS38945.1 | recA | AA2016_0002 | AA2016_3930 | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Recombinase RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.932 |
| AMS38945.1 | topA | AA2016_0002 | AA2016_3857 | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.629 |
| AMS39462.1 | AMS39464.1 | AA2016_0523 | AA2016_0525 | Malic enzyme; Pfam:pfam01515 Phosphate acetyl/butaryl transferase. | Glyoxalase; Pfam:pfam12681 Glyoxalase-like domain. | 0.514 |
| AMS39462.1 | mutS | AA2016_0523 | AA2016_0524 | Malic enzyme; Pfam:pfam01515 Phosphate acetyl/butaryl transferase. | DNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. | 0.678 |
| AMS39464.1 | AMS39462.1 | AA2016_0525 | AA2016_0523 | Glyoxalase; Pfam:pfam12681 Glyoxalase-like domain. | Malic enzyme; Pfam:pfam01515 Phosphate acetyl/butaryl transferase. | 0.514 |
| AMS39464.1 | mutS | AA2016_0525 | AA2016_0524 | Glyoxalase; Pfam:pfam12681 Glyoxalase-like domain. | DNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. | 0.699 |
| AMS42289.1 | AMS42316.1 | AA2016_3367 | AA2016_3394 | DNA repair protein RadC; Pfam:pfam04002 RadC-like JAB domain; Belongs to the UPF0758 family. | Single-stranded DNA exonuclease; Pfam:pfam01368 DHH family. | 0.461 |
| AMS42289.1 | mutL | AA2016_3367 | AA2016_4188 | DNA repair protein RadC; Pfam:pfam04002 RadC-like JAB domain; Belongs to the UPF0758 family. | DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | 0.714 |
| AMS42289.1 | mutS | AA2016_3367 | AA2016_0524 | DNA repair protein RadC; Pfam:pfam04002 RadC-like JAB domain; Belongs to the UPF0758 family. | DNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. | 0.720 |
| AMS42289.1 | recA | AA2016_3367 | AA2016_3930 | DNA repair protein RadC; Pfam:pfam04002 RadC-like JAB domain; Belongs to the UPF0758 family. | Recombinase RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.478 |
| AMS42289.1 | topA | AA2016_3367 | AA2016_3857 | DNA repair protein RadC; Pfam:pfam04002 RadC-like JAB domain; Belongs to the UPF0758 family. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.435 |
| AMS42316.1 | AMS38945.1 | AA2016_3394 | AA2016_0002 | Single-stranded DNA exonuclease; Pfam:pfam01368 DHH family. | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.733 |
| AMS42316.1 | AMS42289.1 | AA2016_3394 | AA2016_3367 | Single-stranded DNA exonuclease; Pfam:pfam01368 DHH family. | DNA repair protein RadC; Pfam:pfam04002 RadC-like JAB domain; Belongs to the UPF0758 family. | 0.461 |
| AMS42316.1 | AMS43023.1 | AA2016_3394 | AA2016_4106 | Single-stranded DNA exonuclease; Pfam:pfam01368 DHH family. | ATP-dependent DNA helicase RecQ; Pfam:pfam09382 RQC domain. | 0.645 |
| AMS42316.1 | mutL | AA2016_3394 | AA2016_4188 | Single-stranded DNA exonuclease; Pfam:pfam01368 DHH family. | DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | 0.657 |
