| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AMS39469.1 | AMS39470.1 | AA2016_0530 | AA2016_0531 | Pfam:pfam06441 Epoxide hydrolase N terminus. | Dihydrofolate reductase. | 0.520 |
| AMS39469.1 | AMS39471.1 | AA2016_0530 | AA2016_0532 | Pfam:pfam06441 Epoxide hydrolase N terminus. | Dihydrofolate reductase; Pfam:pfam01872 RibD C-terminal domain. | 0.585 |
| AMS39470.1 | AMS39469.1 | AA2016_0531 | AA2016_0530 | Dihydrofolate reductase. | Pfam:pfam06441 Epoxide hydrolase N terminus. | 0.520 |
| AMS39470.1 | AMS39471.1 | AA2016_0531 | AA2016_0532 | Dihydrofolate reductase. | Dihydrofolate reductase; Pfam:pfam01872 RibD C-terminal domain. | 0.773 |
| AMS39470.1 | AMS42973.1 | AA2016_0531 | AA2016_4056 | Dihydrofolate reductase. | 5-amino-6-(5-phosphoribosylamino)uracil reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.416 |
| AMS39470.1 | clpX | AA2016_0531 | AA2016_4007 | Dihydrofolate reductase. | ATP-dependent protease; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.548 |
| AMS39470.1 | thyA | AA2016_0531 | AA2016_2853 | Dihydrofolate reductase. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.648 |
| AMS39471.1 | AMS39469.1 | AA2016_0532 | AA2016_0530 | Dihydrofolate reductase; Pfam:pfam01872 RibD C-terminal domain. | Pfam:pfam06441 Epoxide hydrolase N terminus. | 0.585 |
| AMS39471.1 | AMS39470.1 | AA2016_0532 | AA2016_0531 | Dihydrofolate reductase; Pfam:pfam01872 RibD C-terminal domain. | Dihydrofolate reductase. | 0.773 |
| AMS39471.1 | AMS42973.1 | AA2016_0532 | AA2016_4056 | Dihydrofolate reductase; Pfam:pfam01872 RibD C-terminal domain. | 5-amino-6-(5-phosphoribosylamino)uracil reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.416 |
| AMS39471.1 | clpX | AA2016_0532 | AA2016_4007 | Dihydrofolate reductase; Pfam:pfam01872 RibD C-terminal domain. | ATP-dependent protease; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.548 |
| AMS39471.1 | thyA | AA2016_0532 | AA2016_2853 | Dihydrofolate reductase; Pfam:pfam01872 RibD C-terminal domain. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.648 |
| AMS42973.1 | AMS39470.1 | AA2016_4056 | AA2016_0531 | 5-amino-6-(5-phosphoribosylamino)uracil reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Dihydrofolate reductase. | 0.416 |
| AMS42973.1 | AMS39471.1 | AA2016_4056 | AA2016_0532 | 5-amino-6-(5-phosphoribosylamino)uracil reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Dihydrofolate reductase; Pfam:pfam01872 RibD C-terminal domain. | 0.416 |
| AMS42973.1 | clpX | AA2016_4056 | AA2016_4007 | 5-amino-6-(5-phosphoribosylamino)uracil reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | ATP-dependent protease; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.580 |
| AMS42973.1 | thyA | AA2016_4056 | AA2016_2853 | 5-amino-6-(5-phosphoribosylamino)uracil reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.493 |
| clpX | AMS39470.1 | AA2016_4007 | AA2016_0531 | ATP-dependent protease; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | Dihydrofolate reductase. | 0.548 |
| clpX | AMS39471.1 | AA2016_4007 | AA2016_0532 | ATP-dependent protease; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | Dihydrofolate reductase; Pfam:pfam01872 RibD C-terminal domain. | 0.548 |
| clpX | AMS42973.1 | AA2016_4007 | AA2016_4056 | ATP-dependent protease; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 5-amino-6-(5-phosphoribosylamino)uracil reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.580 |
| thyA | AMS39470.1 | AA2016_2853 | AA2016_0531 | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | Dihydrofolate reductase. | 0.648 |