Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AMS39471.1Dihydrofolate reductase; Pfam:pfam01872 RibD C-terminal domain. (127 aa)    
Predicted Functional Partners:
AMS39470.1
Dihydrofolate reductase.
       0.773
AMS43215.1
Bifunctional deaminase-reductase domain protein; Pfam:pfam01872 RibD C-terminal domain.
  
     0.663
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
  
  
 0.648
AMS39469.1
Pfam:pfam06441 Epoxide hydrolase N terminus.
 
    0.585
clpX
ATP-dependent protease; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
   
 
 0.548
AMS39468.1
Transcriptional activator FtrA; Pfam:pfam12833 Helix-turn-helix domain.
 
     0.515
AMS41976.1
AraC family transcriptional regulator; Pfam:pfam12833 Helix-turn-helix domain.
  
     0.489
AMS44072.1
Transcriptional regulator, AraC family; Pfam:pfam12833 Helix-turn-helix domain.
  
     0.444
AMS42973.1
5-amino-6-(5-phosphoribosylamino)uracil reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.
     
 0.416
AMS44296.1
Glyoxalase; Pfam:pfam12681 Glyoxalase-like domain.
 
  
 0.405
Your Current Organism:
Aminobacter aminovorans
NCBI taxonomy Id: 83263
Other names: A. aminovorans, ATCC 23314, ATCC 29600, Aminobacter heintzii, CCUG 2081, CIP 106737, Chelatobacter heintzii, DSM 10368, DSM 7048, JCM 7852, KCTC 2477, LMG 2122, LMG:2122, NCCB 26039, NCIB 9039, NCIB:9039, NCIMB 9039, NCTC 10684, Pseudomonas aminovorans, VKM B-2058
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