| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AMS43555.1 | AMS44045.1 | AA2016_4645 | AA2016_5138 | Pfam:pfam00155 Aminotransferase class I and II. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | 0.912 |
| AMS43555.1 | hisA | AA2016_4645 | AA2016_0778 | Pfam:pfam00155 Aminotransferase class I and II. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Pfam:pfam00977 Histidine biosynthesis protein. | 0.870 |
| AMS43555.1 | hisB | AA2016_4645 | AA2016_0782 | Pfam:pfam00155 Aminotransferase class I and II. | Pfam:pfam00475 Imidazoleglycerol-phosphate dehydratase. | 0.995 |
| AMS43555.1 | hisC | AA2016_4645 | AA2016_1734 | Pfam:pfam00155 Aminotransferase class I and II. | Pfam:pfam00155 Aminotransferase class I and II; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.923 |
| AMS43555.1 | hisD | AA2016_4645 | AA2016_5238 | Pfam:pfam00155 Aminotransferase class I and II. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.983 |
| AMS43555.1 | hisE | AA2016_4645 | AA2016_0776 | Pfam:pfam00155 Aminotransferase class I and II. | Pfam:pfam01503 Phosphoribosyl-ATP pyrophosphohydrolase. | 0.849 |
| AMS43555.1 | hisF | AA2016_4645 | AA2016_0777 | Pfam:pfam00155 Aminotransferase class I and II. | Imidazole glycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.901 |
| AMS43555.1 | hisH | AA2016_4645 | AA2016_0780 | Pfam:pfam00155 Aminotransferase class I and II. | Imidazole glycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.917 |
| AMS43555.1 | hisI | AA2016_4645 | AA2016_3396 | Pfam:pfam00155 Aminotransferase class I and II. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.915 |
| AMS43555.1 | hisZ | AA2016_4645 | AA2016_5139 | Pfam:pfam00155 Aminotransferase class I and II. | ATP phosphoribosyltransferase; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.790 |
| AMS44045.1 | AMS43555.1 | AA2016_5138 | AA2016_4645 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | Pfam:pfam00155 Aminotransferase class I and II. | 0.912 |
| AMS44045.1 | hisA | AA2016_5138 | AA2016_0778 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Pfam:pfam00977 Histidine biosynthesis protein. | 0.980 |
| AMS44045.1 | hisB | AA2016_5138 | AA2016_0782 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | Pfam:pfam00475 Imidazoleglycerol-phosphate dehydratase. | 0.985 |
| AMS44045.1 | hisC | AA2016_5138 | AA2016_1734 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | Pfam:pfam00155 Aminotransferase class I and II; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.901 |
| AMS44045.1 | hisD | AA2016_5138 | AA2016_5238 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.987 |
| AMS44045.1 | hisE | AA2016_5138 | AA2016_0776 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | Pfam:pfam01503 Phosphoribosyl-ATP pyrophosphohydrolase. | 0.997 |
| AMS44045.1 | hisF | AA2016_5138 | AA2016_0777 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | Imidazole glycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.985 |
| AMS44045.1 | hisH | AA2016_5138 | AA2016_0780 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | Imidazole glycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.985 |
| AMS44045.1 | hisI | AA2016_5138 | AA2016_3396 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.985 |
| AMS44045.1 | hisZ | AA2016_5138 | AA2016_5139 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | ATP phosphoribosyltransferase; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.999 |
