| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AMS38945.1 | AMS39342.1 | AA2016_0002 | AA2016_0403 | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Pfam:pfam01068 ATP dependent DNA ligase domain. | 0.790 |
| AMS38945.1 | AMS40001.1 | AA2016_0002 | AA2016_1063 | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Pfam:pfam01028 Eukaryotic DNA topoisomerase I, catalytic core. | 0.742 |
| AMS38945.1 | AMS41138.1 | AA2016_0002 | AA2016_2208 | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Hypothetical protein; Pfam:pfam01068 ATP dependent DNA ligase domain. | 0.790 |
| AMS38945.1 | AMS42506.1 | AA2016_0002 | AA2016_3584 | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Pfam:pfam13298 DNA polymerase Ligase (LigD). | 0.814 |
| AMS38945.1 | AMS43023.1 | AA2016_0002 | AA2016_4106 | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | ATP-dependent DNA helicase RecQ; Pfam:pfam09382 RQC domain. | 0.860 |
| AMS38945.1 | gyrB | AA2016_0002 | AA2016_0108 | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.866 |
| AMS38945.1 | parE | AA2016_0002 | AA2016_3410 | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA topoisomerase IV subunit B; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 1 subfamily. | 0.776 |
| AMS38945.1 | rnhB | AA2016_0002 | AA2016_4888 | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.927 |
| AMS39342.1 | AMS38945.1 | AA2016_0403 | AA2016_0002 | Pfam:pfam01068 ATP dependent DNA ligase domain. | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.790 |
| AMS39342.1 | AMS40001.1 | AA2016_0403 | AA2016_1063 | Pfam:pfam01068 ATP dependent DNA ligase domain. | Pfam:pfam01028 Eukaryotic DNA topoisomerase I, catalytic core. | 0.727 |
| AMS39342.1 | AMS41138.1 | AA2016_0403 | AA2016_2208 | Pfam:pfam01068 ATP dependent DNA ligase domain. | Hypothetical protein; Pfam:pfam01068 ATP dependent DNA ligase domain. | 0.903 |
| AMS39342.1 | ku | AA2016_0403 | AA2016_3583 | Pfam:pfam01068 ATP dependent DNA ligase domain. | ATP-dependent DNA ligase; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family. | 0.856 |
| AMS39710.1 | AMS40001.1 | AA2016_0772 | AA2016_1063 | peptidyl-tRNA hydrolase; Pfam:pfam00472 RF-1 domain. | Pfam:pfam01028 Eukaryotic DNA topoisomerase I, catalytic core. | 0.631 |
| AMS40001.1 | AMS38945.1 | AA2016_1063 | AA2016_0002 | Pfam:pfam01028 Eukaryotic DNA topoisomerase I, catalytic core. | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.742 |
| AMS40001.1 | AMS39342.1 | AA2016_1063 | AA2016_0403 | Pfam:pfam01028 Eukaryotic DNA topoisomerase I, catalytic core. | Pfam:pfam01068 ATP dependent DNA ligase domain. | 0.727 |
| AMS40001.1 | AMS39710.1 | AA2016_1063 | AA2016_0772 | Pfam:pfam01028 Eukaryotic DNA topoisomerase I, catalytic core. | peptidyl-tRNA hydrolase; Pfam:pfam00472 RF-1 domain. | 0.631 |
| AMS40001.1 | AMS41138.1 | AA2016_1063 | AA2016_2208 | Pfam:pfam01028 Eukaryotic DNA topoisomerase I, catalytic core. | Hypothetical protein; Pfam:pfam01068 ATP dependent DNA ligase domain. | 0.735 |
| AMS40001.1 | AMS42506.1 | AA2016_1063 | AA2016_3584 | Pfam:pfam01028 Eukaryotic DNA topoisomerase I, catalytic core. | Pfam:pfam13298 DNA polymerase Ligase (LigD). | 0.833 |
| AMS40001.1 | AMS43023.1 | AA2016_1063 | AA2016_4106 | Pfam:pfam01028 Eukaryotic DNA topoisomerase I, catalytic core. | ATP-dependent DNA helicase RecQ; Pfam:pfam09382 RQC domain. | 0.827 |
| AMS40001.1 | gyrB | AA2016_1063 | AA2016_0108 | Pfam:pfam01028 Eukaryotic DNA topoisomerase I, catalytic core. | DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.806 |
