| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AMS39211.1 | AMS40590.1 | AA2016_0271 | AA2016_1658 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Hypothetical protein; Pfam:pfam00300 Histidine phosphatase superfamily (branch 1); Belongs to the phosphoglycerate mutase family. | 0.520 |
| AMS39211.1 | AMS41888.1 | AA2016_0271 | AA2016_2964 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Adenosylcobinamide kinase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. | 0.634 |
| AMS39211.1 | cobQ | AA2016_0271 | AA2016_3050 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.628 |
| AMS39211.1 | cobS | AA2016_0271 | AA2016_2911 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Hypothetical protein; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.619 |
| AMS40484.1 | AMS40590.1 | AA2016_1552 | AA2016_1658 | Pfam:pfam02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. | Hypothetical protein; Pfam:pfam00300 Histidine phosphatase superfamily (branch 1); Belongs to the phosphoglycerate mutase family. | 0.609 |
| AMS40484.1 | gpmA | AA2016_1552 | AA2016_0700 | Pfam:pfam02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. | Phosphoglyceromutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. | 0.737 |
| AMS40590.1 | AMS39211.1 | AA2016_1658 | AA2016_0271 | Hypothetical protein; Pfam:pfam00300 Histidine phosphatase superfamily (branch 1); Belongs to the phosphoglycerate mutase family. | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.520 |
| AMS40590.1 | AMS40484.1 | AA2016_1658 | AA2016_1552 | Hypothetical protein; Pfam:pfam00300 Histidine phosphatase superfamily (branch 1); Belongs to the phosphoglycerate mutase family. | Pfam:pfam02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. | 0.609 |
| AMS40590.1 | AMS40591.1 | AA2016_1658 | AA2016_1659 | Hypothetical protein; Pfam:pfam00300 Histidine phosphatase superfamily (branch 1); Belongs to the phosphoglycerate mutase family. | Pfam:pfam00005 ABC transporter; Belongs to the ABC transporter superfamily. | 0.774 |
| AMS40590.1 | AMS40592.1 | AA2016_1658 | AA2016_1660 | Hypothetical protein; Pfam:pfam00300 Histidine phosphatase superfamily (branch 1); Belongs to the phosphoglycerate mutase family. | ABC transporter permease; Pfam:pfam00528 Binding-protein-dependent transport system inner membrane component. | 0.777 |
| AMS40590.1 | AMS40593.1 | AA2016_1658 | AA2016_1661 | Hypothetical protein; Pfam:pfam00300 Histidine phosphatase superfamily (branch 1); Belongs to the phosphoglycerate mutase family. | Hypothetical protein; Pfam:pfam13343 Bacterial extracellular solute-binding protein. | 0.586 |
| AMS40590.1 | AMS40594.1 | AA2016_1658 | AA2016_1662 | Hypothetical protein; Pfam:pfam00300 Histidine phosphatase superfamily (branch 1); Belongs to the phosphoglycerate mutase family. | Hypothetical protein; Pfam:pfam01418 Helix-turn-helix domain, rpiR family. | 0.552 |
| AMS40590.1 | AMS41888.1 | AA2016_1658 | AA2016_2964 | Hypothetical protein; Pfam:pfam00300 Histidine phosphatase superfamily (branch 1); Belongs to the phosphoglycerate mutase family. | Adenosylcobinamide kinase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. | 0.535 |
| AMS40590.1 | cobQ | AA2016_1658 | AA2016_3050 | Hypothetical protein; Pfam:pfam00300 Histidine phosphatase superfamily (branch 1); Belongs to the phosphoglycerate mutase family. | Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.650 |
| AMS40590.1 | cobS | AA2016_1658 | AA2016_2911 | Hypothetical protein; Pfam:pfam00300 Histidine phosphatase superfamily (branch 1); Belongs to the phosphoglycerate mutase family. | Hypothetical protein; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.634 |
| AMS40590.1 | gpmA | AA2016_1658 | AA2016_0700 | Hypothetical protein; Pfam:pfam00300 Histidine phosphatase superfamily (branch 1); Belongs to the phosphoglycerate mutase family. | Phosphoglyceromutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. | 0.685 |
| AMS40591.1 | AMS40590.1 | AA2016_1659 | AA2016_1658 | Pfam:pfam00005 ABC transporter; Belongs to the ABC transporter superfamily. | Hypothetical protein; Pfam:pfam00300 Histidine phosphatase superfamily (branch 1); Belongs to the phosphoglycerate mutase family. | 0.774 |
| AMS40591.1 | AMS40592.1 | AA2016_1659 | AA2016_1660 | Pfam:pfam00005 ABC transporter; Belongs to the ABC transporter superfamily. | ABC transporter permease; Pfam:pfam00528 Binding-protein-dependent transport system inner membrane component. | 0.869 |
| AMS40591.1 | AMS40593.1 | AA2016_1659 | AA2016_1661 | Pfam:pfam00005 ABC transporter; Belongs to the ABC transporter superfamily. | Hypothetical protein; Pfam:pfam13343 Bacterial extracellular solute-binding protein. | 0.668 |
| AMS40591.1 | AMS40594.1 | AA2016_1659 | AA2016_1662 | Pfam:pfam00005 ABC transporter; Belongs to the ABC transporter superfamily. | Hypothetical protein; Pfam:pfam01418 Helix-turn-helix domain, rpiR family. | 0.485 |