| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AMS39211.1 | AMS40839.1 | AA2016_0271 | AA2016_1909 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Pfam:pfam00202 Aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.533 |
| AMS39211.1 | AMS42981.1 | AA2016_0271 | AA2016_4064 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Pfam:pfam00490 Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.875 |
| AMS39211.1 | hemC | AA2016_0271 | AA2016_1034 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.970 |
| AMS40735.1 | AMS40839.1 | AA2016_1805 | AA2016_1909 | Pfam:pfam00696 Amino acid kinase family; Belongs to the aspartokinase family. | Pfam:pfam00202 Aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.593 |
| AMS40838.1 | AMS40839.1 | AA2016_1908 | AA2016_1909 | Pfam:pfam00120 Glutamine synthetase, catalytic domain. | Pfam:pfam00202 Aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.900 |
| AMS40838.1 | AMS40840.1 | AA2016_1908 | AA2016_1910 | Pfam:pfam00120 Glutamine synthetase, catalytic domain. | Hypothetical protein. | 0.463 |
| AMS40838.1 | AMS41509.1 | AA2016_1908 | AA2016_2584 | Pfam:pfam00120 Glutamine synthetase, catalytic domain. | Hypothetical protein; Pfam:pfam00285 Citrate synthase; Belongs to the citrate synthase family. | 0.415 |
| AMS40838.1 | AMS41968.1 | AA2016_1908 | AA2016_3044 | Pfam:pfam00120 Glutamine synthetase, catalytic domain. | Pfam:pfam00202 Aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.470 |
| AMS40839.1 | AMS39211.1 | AA2016_1909 | AA2016_0271 | Pfam:pfam00202 Aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.533 |
| AMS40839.1 | AMS40735.1 | AA2016_1909 | AA2016_1805 | Pfam:pfam00202 Aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Pfam:pfam00696 Amino acid kinase family; Belongs to the aspartokinase family. | 0.593 |
| AMS40839.1 | AMS40838.1 | AA2016_1909 | AA2016_1908 | Pfam:pfam00202 Aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Pfam:pfam00120 Glutamine synthetase, catalytic domain. | 0.900 |
| AMS40839.1 | AMS40840.1 | AA2016_1909 | AA2016_1910 | Pfam:pfam00202 Aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Hypothetical protein. | 0.526 |
| AMS40839.1 | AMS41509.1 | AA2016_1909 | AA2016_2584 | Pfam:pfam00202 Aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Hypothetical protein; Pfam:pfam00285 Citrate synthase; Belongs to the citrate synthase family. | 0.577 |
| AMS40839.1 | AMS41510.1 | AA2016_1909 | AA2016_2585 | Pfam:pfam00202 Aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Pfam:pfam00285 Citrate synthase; Belongs to the citrate synthase family. | 0.550 |
| AMS40839.1 | AMS41968.1 | AA2016_1909 | AA2016_3044 | Pfam:pfam00202 Aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Pfam:pfam00202 Aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.584 |
| AMS40839.1 | AMS42981.1 | AA2016_1909 | AA2016_4064 | Pfam:pfam00202 Aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Pfam:pfam00490 Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.983 |
| AMS40839.1 | AMS44194.1 | AA2016_1909 | AA2016_5288 | Pfam:pfam00202 Aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 5-aminolevulinate synthase; Pfam:pfam00155 Aminotransferase class I and II. | 0.908 |
| AMS40839.1 | hemC | AA2016_1909 | AA2016_1034 | Pfam:pfam00202 Aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.838 |
| AMS40840.1 | AMS40838.1 | AA2016_1910 | AA2016_1908 | Hypothetical protein. | Pfam:pfam00120 Glutamine synthetase, catalytic domain. | 0.463 |
| AMS40840.1 | AMS40839.1 | AA2016_1910 | AA2016_1909 | Hypothetical protein. | Pfam:pfam00202 Aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.526 |