| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AMS39694.1 | AMS41343.1 | AA2016_0756 | AA2016_2417 | Folylpolyglutamate synthase; Pfam:pfam08245 Mur ligase middle domain; Belongs to the folylpolyglutamate synthase family. | Dihydrofolate reductase; Pfam:pfam01872 RibD C-terminal domain. | 0.547 |
| AMS39694.1 | AMS42973.1 | AA2016_0756 | AA2016_4056 | Folylpolyglutamate synthase; Pfam:pfam08245 Mur ligase middle domain; Belongs to the folylpolyglutamate synthase family. | 5-amino-6-(5-phosphoribosylamino)uracil reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.634 |
| AMS39694.1 | thyA | AA2016_0756 | AA2016_2853 | Folylpolyglutamate synthase; Pfam:pfam08245 Mur ligase middle domain; Belongs to the folylpolyglutamate synthase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.855 |
| AMS41343.1 | AMS39694.1 | AA2016_2417 | AA2016_0756 | Dihydrofolate reductase; Pfam:pfam01872 RibD C-terminal domain. | Folylpolyglutamate synthase; Pfam:pfam08245 Mur ligase middle domain; Belongs to the folylpolyglutamate synthase family. | 0.547 |
| AMS41343.1 | AMS41551.1 | AA2016_2417 | AA2016_2626 | Dihydrofolate reductase; Pfam:pfam01872 RibD C-terminal domain. | Pfam:pfam01571 Aminomethyltransferase folate-binding domain. | 0.511 |
| AMS41343.1 | AMS42337.1 | AA2016_2417 | AA2016_3415 | Dihydrofolate reductase; Pfam:pfam01872 RibD C-terminal domain. | Glycine cleavage system protein T; Pfam:pfam01571 Aminomethyltransferase folate-binding domain. | 0.511 |
| AMS41343.1 | AMS42973.1 | AA2016_2417 | AA2016_4056 | Dihydrofolate reductase; Pfam:pfam01872 RibD C-terminal domain. | 5-amino-6-(5-phosphoribosylamino)uracil reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.416 |
| AMS41343.1 | clpX | AA2016_2417 | AA2016_4007 | Dihydrofolate reductase; Pfam:pfam01872 RibD C-terminal domain. | ATP-dependent protease; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.548 |
| AMS41343.1 | pth | AA2016_2417 | AA2016_2418 | Dihydrofolate reductase; Pfam:pfam01872 RibD C-terminal domain. | peptidyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family. | 0.423 |
| AMS41343.1 | thyA | AA2016_2417 | AA2016_2853 | Dihydrofolate reductase; Pfam:pfam01872 RibD C-terminal domain. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.816 |
| AMS41343.1 | ychF | AA2016_2417 | AA2016_2416 | Dihydrofolate reductase; Pfam:pfam01872 RibD C-terminal domain. | GTP-binding protein YchF; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner. | 0.572 |
| AMS41551.1 | AMS41343.1 | AA2016_2626 | AA2016_2417 | Pfam:pfam01571 Aminomethyltransferase folate-binding domain. | Dihydrofolate reductase; Pfam:pfam01872 RibD C-terminal domain. | 0.511 |
| AMS41551.1 | AMS42337.1 | AA2016_2626 | AA2016_3415 | Pfam:pfam01571 Aminomethyltransferase folate-binding domain. | Glycine cleavage system protein T; Pfam:pfam01571 Aminomethyltransferase folate-binding domain. | 0.550 |
| AMS41551.1 | thyA | AA2016_2626 | AA2016_2853 | Pfam:pfam01571 Aminomethyltransferase folate-binding domain. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.907 |
| AMS42337.1 | AMS41343.1 | AA2016_3415 | AA2016_2417 | Glycine cleavage system protein T; Pfam:pfam01571 Aminomethyltransferase folate-binding domain. | Dihydrofolate reductase; Pfam:pfam01872 RibD C-terminal domain. | 0.511 |
| AMS42337.1 | AMS41551.1 | AA2016_3415 | AA2016_2626 | Glycine cleavage system protein T; Pfam:pfam01571 Aminomethyltransferase folate-binding domain. | Pfam:pfam01571 Aminomethyltransferase folate-binding domain. | 0.550 |
| AMS42337.1 | thyA | AA2016_3415 | AA2016_2853 | Glycine cleavage system protein T; Pfam:pfam01571 Aminomethyltransferase folate-binding domain. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.907 |
| AMS42973.1 | AMS39694.1 | AA2016_4056 | AA2016_0756 | 5-amino-6-(5-phosphoribosylamino)uracil reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Folylpolyglutamate synthase; Pfam:pfam08245 Mur ligase middle domain; Belongs to the folylpolyglutamate synthase family. | 0.634 |
| AMS42973.1 | AMS41343.1 | AA2016_4056 | AA2016_2417 | 5-amino-6-(5-phosphoribosylamino)uracil reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Dihydrofolate reductase; Pfam:pfam01872 RibD C-terminal domain. | 0.416 |
| AMS42973.1 | clpX | AA2016_4056 | AA2016_4007 | 5-amino-6-(5-phosphoribosylamino)uracil reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | ATP-dependent protease; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.580 |