| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AMS41548.1 | AMS41551.1 | AA2016_2623 | AA2016_2626 | L-serine ammonia-lyase; Pfam:pfam03313 Serine dehydratase alpha chain; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Pfam:pfam01571 Aminomethyltransferase folate-binding domain. | 0.675 |
| AMS41548.1 | gcvP | AA2016_2623 | AA2016_2624 | L-serine ammonia-lyase; Pfam:pfam03313 Serine dehydratase alpha chain; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.849 |
| AMS41548.1 | gcvP-2 | AA2016_2623 | AA2016_3413 | L-serine ammonia-lyase; Pfam:pfam03313 Serine dehydratase alpha chain; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.626 |
| AMS41548.1 | glyA | AA2016_2623 | AA2016_2628 | L-serine ammonia-lyase; Pfam:pfam03313 Serine dehydratase alpha chain; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.966 |
| AMS41551.1 | AMS41548.1 | AA2016_2626 | AA2016_2623 | Pfam:pfam01571 Aminomethyltransferase folate-binding domain. | L-serine ammonia-lyase; Pfam:pfam03313 Serine dehydratase alpha chain; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.675 |
| AMS41551.1 | AMS42337.1 | AA2016_2626 | AA2016_3415 | Pfam:pfam01571 Aminomethyltransferase folate-binding domain. | Glycine cleavage system protein T; Pfam:pfam01571 Aminomethyltransferase folate-binding domain. | 0.550 |
| AMS41551.1 | folD | AA2016_2626 | AA2016_5145 | Pfam:pfam01571 Aminomethyltransferase folate-binding domain. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.754 |
| AMS41551.1 | folD-2 | AA2016_2626 | AA2016_5213 | Pfam:pfam01571 Aminomethyltransferase folate-binding domain. | 5,10-methylene-tetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.754 |
| AMS41551.1 | folD-3 | AA2016_2626 | AA2016_5259 | Pfam:pfam01571 Aminomethyltransferase folate-binding domain. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.754 |
| AMS41551.1 | gcvP | AA2016_2626 | AA2016_2624 | Pfam:pfam01571 Aminomethyltransferase folate-binding domain. | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.999 |
| AMS41551.1 | gcvP-2 | AA2016_2626 | AA2016_3413 | Pfam:pfam01571 Aminomethyltransferase folate-binding domain. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.997 |
| AMS41551.1 | glyA | AA2016_2626 | AA2016_2628 | Pfam:pfam01571 Aminomethyltransferase folate-binding domain. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.986 |
| AMS41551.1 | purH | AA2016_2626 | AA2016_1256 | Pfam:pfam01571 Aminomethyltransferase folate-binding domain. | Pfam:pfam01808 AICARFT/IMPCHase bienzyme. | 0.920 |
| AMS41551.1 | purN | AA2016_2626 | AA2016_4456 | Pfam:pfam01571 Aminomethyltransferase folate-binding domain. | Hypothetical protein; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.913 |
| AMS42337.1 | AMS41551.1 | AA2016_3415 | AA2016_2626 | Glycine cleavage system protein T; Pfam:pfam01571 Aminomethyltransferase folate-binding domain. | Pfam:pfam01571 Aminomethyltransferase folate-binding domain. | 0.550 |
| AMS42337.1 | folD | AA2016_3415 | AA2016_5145 | Glycine cleavage system protein T; Pfam:pfam01571 Aminomethyltransferase folate-binding domain. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.754 |
| AMS42337.1 | folD-2 | AA2016_3415 | AA2016_5213 | Glycine cleavage system protein T; Pfam:pfam01571 Aminomethyltransferase folate-binding domain. | 5,10-methylene-tetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.754 |
| AMS42337.1 | folD-3 | AA2016_3415 | AA2016_5259 | Glycine cleavage system protein T; Pfam:pfam01571 Aminomethyltransferase folate-binding domain. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.754 |
| AMS42337.1 | gcvP | AA2016_3415 | AA2016_2624 | Glycine cleavage system protein T; Pfam:pfam01571 Aminomethyltransferase folate-binding domain. | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.997 |
| AMS42337.1 | gcvP-2 | AA2016_3415 | AA2016_3413 | Glycine cleavage system protein T; Pfam:pfam01571 Aminomethyltransferase folate-binding domain. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.999 |
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