| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AMS39129.1 | AMS41780.1 | AA2016_0187 | AA2016_2855 | Homocysteine-N5-methyltetrahydrofolate transmethylase, B12-dependent; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Diacylglycerol kinase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.912 |
| AMS39129.1 | fhs | AA2016_0187 | AA2016_2364 | Homocysteine-N5-methyltetrahydrofolate transmethylase, B12-dependent; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Pfam:pfam01268 Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.951 |
| AMS39129.1 | fhs-2 | AA2016_0187 | AA2016_5260 | Homocysteine-N5-methyltetrahydrofolate transmethylase, B12-dependent; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Pfam:pfam01268 Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.951 |
| AMS39129.1 | glyA | AA2016_0187 | AA2016_2628 | Homocysteine-N5-methyltetrahydrofolate transmethylase, B12-dependent; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.936 |
| AMS39129.1 | glyA-2 | AA2016_0187 | AA2016_4058 | Homocysteine-N5-methyltetrahydrofolate transmethylase, B12-dependent; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.936 |
| AMS39129.1 | purH | AA2016_0187 | AA2016_1256 | Homocysteine-N5-methyltetrahydrofolate transmethylase, B12-dependent; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Pfam:pfam01808 AICARFT/IMPCHase bienzyme. | 0.914 |
| AMS39129.1 | purN | AA2016_0187 | AA2016_4456 | Homocysteine-N5-methyltetrahydrofolate transmethylase, B12-dependent; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Hypothetical protein; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.909 |
| AMS39694.1 | AMS41780.1 | AA2016_0756 | AA2016_2855 | Folylpolyglutamate synthase; Pfam:pfam08245 Mur ligase middle domain; Belongs to the folylpolyglutamate synthase family. | Diacylglycerol kinase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.927 |
| AMS39694.1 | fhs | AA2016_0756 | AA2016_2364 | Folylpolyglutamate synthase; Pfam:pfam08245 Mur ligase middle domain; Belongs to the folylpolyglutamate synthase family. | Pfam:pfam01268 Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.619 |
| AMS39694.1 | fhs-2 | AA2016_0756 | AA2016_5260 | Folylpolyglutamate synthase; Pfam:pfam08245 Mur ligase middle domain; Belongs to the folylpolyglutamate synthase family. | Pfam:pfam01268 Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.619 |
| AMS39694.1 | glyA | AA2016_0756 | AA2016_2628 | Folylpolyglutamate synthase; Pfam:pfam08245 Mur ligase middle domain; Belongs to the folylpolyglutamate synthase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.646 |
| AMS39694.1 | glyA-2 | AA2016_0756 | AA2016_4058 | Folylpolyglutamate synthase; Pfam:pfam08245 Mur ligase middle domain; Belongs to the folylpolyglutamate synthase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.646 |
| AMS39694.1 | thyA | AA2016_0756 | AA2016_2853 | Folylpolyglutamate synthase; Pfam:pfam08245 Mur ligase middle domain; Belongs to the folylpolyglutamate synthase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.855 |
| AMS41780.1 | AMS39129.1 | AA2016_2855 | AA2016_0187 | Diacylglycerol kinase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Homocysteine-N5-methyltetrahydrofolate transmethylase, B12-dependent; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.912 |
| AMS41780.1 | AMS39694.1 | AA2016_2855 | AA2016_0756 | Diacylglycerol kinase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Folylpolyglutamate synthase; Pfam:pfam08245 Mur ligase middle domain; Belongs to the folylpolyglutamate synthase family. | 0.927 |
| AMS41780.1 | AMS44344.1 | AA2016_2855 | AA2016_5438 | Diacylglycerol kinase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Phenylalanine 4-monooxygenase; Pfam:pfam00351 Biopterin-dependent aromatic amino acid hydroxylase. | 0.908 |
| AMS41780.1 | fhs | AA2016_2855 | AA2016_2364 | Diacylglycerol kinase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Pfam:pfam01268 Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.919 |
| AMS41780.1 | fhs-2 | AA2016_2855 | AA2016_5260 | Diacylglycerol kinase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Pfam:pfam01268 Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.919 |
| AMS41780.1 | glyA | AA2016_2855 | AA2016_2628 | Diacylglycerol kinase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.917 |
| AMS41780.1 | glyA-2 | AA2016_2855 | AA2016_4058 | Diacylglycerol kinase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.917 |
