| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AMS39190.1 | AMS39699.1 | AA2016_0249 | AA2016_0761 | Hypothetical protein. | Hypothetical protein; Pfam:pfam02367 Uncharacterized P-loop hydrolase UPF0079. | 0.508 |
| AMS39190.1 | AMS41783.1 | AA2016_0249 | AA2016_2858 | Hypothetical protein. | Pfam:pfam09838 Uncharacterized protein conserved in bacteria (DUF2065). | 0.535 |
| AMS39190.1 | AMS41892.1 | AA2016_0249 | AA2016_2968 | Hypothetical protein. | Protein tyrosine/serine phosphatase. | 0.649 |
| AMS39190.1 | AMS42363.1 | AA2016_0249 | AA2016_3441 | Hypothetical protein. | Hypothetical protein. | 0.669 |
| AMS39699.1 | AMS39190.1 | AA2016_0761 | AA2016_0249 | Hypothetical protein; Pfam:pfam02367 Uncharacterized P-loop hydrolase UPF0079. | Hypothetical protein. | 0.508 |
| AMS39699.1 | AMS41783.1 | AA2016_0761 | AA2016_2858 | Hypothetical protein; Pfam:pfam02367 Uncharacterized P-loop hydrolase UPF0079. | Pfam:pfam09838 Uncharacterized protein conserved in bacteria (DUF2065). | 0.533 |
| AMS39699.1 | AMS41892.1 | AA2016_0761 | AA2016_2968 | Hypothetical protein; Pfam:pfam02367 Uncharacterized P-loop hydrolase UPF0079. | Protein tyrosine/serine phosphatase. | 0.581 |
| AMS39699.1 | nnrD | AA2016_0761 | AA2016_3754 | Hypothetical protein; Pfam:pfam02367 Uncharacterized P-loop hydrolase UPF0079. | Carbohydrate kinase, YjeF related protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow t [...] | 0.806 |
| AMS41780.1 | AMS41781.1 | AA2016_2855 | AA2016_2856 | Diacylglycerol kinase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Modulator for HflB protease specific for phage lambda cII repressor; HflC and HflK could encode or regulate a protease. | 0.583 |
| AMS41780.1 | AMS41782.1 | AA2016_2855 | AA2016_2857 | Diacylglycerol kinase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Membrane protein; HflC and HflK could regulate a protease. | 0.583 |
| AMS41780.1 | AMS41783.1 | AA2016_2855 | AA2016_2858 | Diacylglycerol kinase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Pfam:pfam09838 Uncharacterized protein conserved in bacteria (DUF2065). | 0.583 |
| AMS41780.1 | thyA | AA2016_2855 | AA2016_2853 | Diacylglycerol kinase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.999 |
| AMS41781.1 | AMS41780.1 | AA2016_2856 | AA2016_2855 | Modulator for HflB protease specific for phage lambda cII repressor; HflC and HflK could encode or regulate a protease. | Diacylglycerol kinase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.583 |
| AMS41781.1 | AMS41782.1 | AA2016_2856 | AA2016_2857 | Modulator for HflB protease specific for phage lambda cII repressor; HflC and HflK could encode or regulate a protease. | Membrane protein; HflC and HflK could regulate a protease. | 0.995 |
| AMS41781.1 | AMS41783.1 | AA2016_2856 | AA2016_2858 | Modulator for HflB protease specific for phage lambda cII repressor; HflC and HflK could encode or regulate a protease. | Pfam:pfam09838 Uncharacterized protein conserved in bacteria (DUF2065). | 0.821 |
| AMS41781.1 | AMS41784.1 | AA2016_2856 | AA2016_2859 | Modulator for HflB protease specific for phage lambda cII repressor; HflC and HflK could encode or regulate a protease. | Serine protease; Pfam:pfam13365 Trypsin-like peptidase domain; Belongs to the peptidase S1C family. | 0.711 |
| AMS41781.1 | thyA | AA2016_2856 | AA2016_2853 | Modulator for HflB protease specific for phage lambda cII repressor; HflC and HflK could encode or regulate a protease. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.555 |
| AMS41782.1 | AMS41780.1 | AA2016_2857 | AA2016_2855 | Membrane protein; HflC and HflK could regulate a protease. | Diacylglycerol kinase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.583 |
| AMS41782.1 | AMS41781.1 | AA2016_2857 | AA2016_2856 | Membrane protein; HflC and HflK could regulate a protease. | Modulator for HflB protease specific for phage lambda cII repressor; HflC and HflK could encode or regulate a protease. | 0.995 |
| AMS41782.1 | AMS41783.1 | AA2016_2857 | AA2016_2858 | Membrane protein; HflC and HflK could regulate a protease. | Pfam:pfam09838 Uncharacterized protein conserved in bacteria (DUF2065). | 0.821 |
