| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AMS39738.1 | AMS42689.1 | AA2016_0800 | AA2016_3769 | Septum formation protein Maf; Nucleoside triphosphate pyrophosphatase that hydrolyzes 7- methyl-GTP (m(7)GTP). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids; Belongs to the Maf family. YceF subfamily. | Nucleoside triphosphate pyrophosphohydrolase; Pfam:pfam03819 MazG nucleotide pyrophosphohydrolase domain. | 0.917 |
| AMS39738.1 | cmk | AA2016_0800 | AA2016_0674 | Septum formation protein Maf; Nucleoside triphosphate pyrophosphatase that hydrolyzes 7- methyl-GTP (m(7)GTP). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids; Belongs to the Maf family. YceF subfamily. | Pfam:pfam02224 Cytidylate kinase. | 0.918 |
| AMS39738.1 | pyrG | AA2016_0800 | AA2016_3797 | Septum formation protein Maf; Nucleoside triphosphate pyrophosphatase that hydrolyzes 7- methyl-GTP (m(7)GTP). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids; Belongs to the Maf family. YceF subfamily. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.910 |
| AMS39738.1 | thyA | AA2016_0800 | AA2016_2853 | Septum formation protein Maf; Nucleoside triphosphate pyrophosphatase that hydrolyzes 7- methyl-GTP (m(7)GTP). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids; Belongs to the Maf family. YceF subfamily. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.900 |
| AMS39738.1 | tmk | AA2016_0800 | AA2016_3542 | Septum formation protein Maf; Nucleoside triphosphate pyrophosphatase that hydrolyzes 7- methyl-GTP (m(7)GTP). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids; Belongs to the Maf family. YceF subfamily. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.919 |
| AMS40676.1 | AMS42689.1 | AA2016_1744 | AA2016_3769 | Hypoxanthine phosphoribosyltransferase; Pfam:pfam00156 Phosphoribosyl transferase domain; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Nucleoside triphosphate pyrophosphohydrolase; Pfam:pfam03819 MazG nucleotide pyrophosphohydrolase domain. | 0.929 |
| AMS40676.1 | adk | AA2016_1744 | AA2016_3525 | Hypoxanthine phosphoribosyltransferase; Pfam:pfam00156 Phosphoribosyl transferase domain; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | 0.525 |
| AMS40676.1 | cmk | AA2016_1744 | AA2016_0674 | Hypoxanthine phosphoribosyltransferase; Pfam:pfam00156 Phosphoribosyl transferase domain; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Pfam:pfam02224 Cytidylate kinase. | 0.469 |
| AMS42689.1 | AMS39738.1 | AA2016_3769 | AA2016_0800 | Nucleoside triphosphate pyrophosphohydrolase; Pfam:pfam03819 MazG nucleotide pyrophosphohydrolase domain. | Septum formation protein Maf; Nucleoside triphosphate pyrophosphatase that hydrolyzes 7- methyl-GTP (m(7)GTP). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids; Belongs to the Maf family. YceF subfamily. | 0.917 |
| AMS42689.1 | AMS40676.1 | AA2016_3769 | AA2016_1744 | Nucleoside triphosphate pyrophosphohydrolase; Pfam:pfam03819 MazG nucleotide pyrophosphohydrolase domain. | Hypoxanthine phosphoribosyltransferase; Pfam:pfam00156 Phosphoribosyl transferase domain; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.929 |
| AMS42689.1 | AMS42700.1 | AA2016_3769 | AA2016_3780 | Nucleoside triphosphate pyrophosphohydrolase; Pfam:pfam03819 MazG nucleotide pyrophosphohydrolase domain. | CinA domain protein; Pfam:pfam02464 Competence-damaged protein; Belongs to the CinA family. | 0.916 |
| AMS42689.1 | AMS43542.1 | AA2016_3769 | AA2016_4632 | Nucleoside triphosphate pyrophosphohydrolase; Pfam:pfam03819 MazG nucleotide pyrophosphohydrolase domain. | GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 0.923 |
| AMS42689.1 | adk | AA2016_3769 | AA2016_3525 | Nucleoside triphosphate pyrophosphohydrolase; Pfam:pfam03819 MazG nucleotide pyrophosphohydrolase domain. | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | 0.917 |
| AMS42689.1 | cmk | AA2016_3769 | AA2016_0674 | Nucleoside triphosphate pyrophosphohydrolase; Pfam:pfam03819 MazG nucleotide pyrophosphohydrolase domain. | Pfam:pfam02224 Cytidylate kinase. | 0.924 |
| AMS42689.1 | pncB | AA2016_3769 | AA2016_0455 | Nucleoside triphosphate pyrophosphohydrolase; Pfam:pfam03819 MazG nucleotide pyrophosphohydrolase domain. | Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. | 0.916 |
| AMS42689.1 | pyrG | AA2016_3769 | AA2016_3797 | Nucleoside triphosphate pyrophosphohydrolase; Pfam:pfam03819 MazG nucleotide pyrophosphohydrolase domain. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.917 |
| AMS42689.1 | thyA | AA2016_3769 | AA2016_2853 | Nucleoside triphosphate pyrophosphohydrolase; Pfam:pfam03819 MazG nucleotide pyrophosphohydrolase domain. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.932 |
| AMS42689.1 | tmk | AA2016_3769 | AA2016_3542 | Nucleoside triphosphate pyrophosphohydrolase; Pfam:pfam03819 MazG nucleotide pyrophosphohydrolase domain. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.921 |
| AMS42700.1 | AMS42689.1 | AA2016_3780 | AA2016_3769 | CinA domain protein; Pfam:pfam02464 Competence-damaged protein; Belongs to the CinA family. | Nucleoside triphosphate pyrophosphohydrolase; Pfam:pfam03819 MazG nucleotide pyrophosphohydrolase domain. | 0.916 |
| AMS42700.1 | pncB | AA2016_3780 | AA2016_0455 | CinA domain protein; Pfam:pfam02464 Competence-damaged protein; Belongs to the CinA family. | Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. | 0.937 |