STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
glnEGlutamine-synthetase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transducti [...] (987 aa)    
Predicted Functional Partners:
AMS43592.1
Pfam:pfam00486 Transcriptional regulatory protein, C terminal.
     
 0.812
AMS43591.1
Pfam:pfam02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase.
     
 0.797
glnD
protein-PII uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism.
 
   
 0.790
AMS42871.1
Alkyl hydroperoxide reductase; Pfam:pfam00578 AhpC/TSA family.
     0.702
AMS43589.1
Acid-shock protein.
       0.614
AMS42676.1
Pfam:pfam00120 Glutamine synthetase, catalytic domain.
 
  
 0.596
AMS43593.1
Serine protease; Pfam:pfam13365 Trypsin-like peptidase domain; Belongs to the peptidase S1C family.
  
  
 0.566
AMS40947.1
Glutamate synthase; Pfam:pfam01645 Conserved region in glutamate synthase.
     
 0.535
AMS40554.1
Hypothetical protein; Pfam:pfam02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase.
     
 0.494
AMS43597.1
Cytochrome C.
 
     0.492
Your Current Organism:
Aminobacter aminovorans
NCBI taxonomy Id: 83263
Other names: A. aminovorans, ATCC 23314, ATCC 29600, Aminobacter heintzii, CCUG 2081, CIP 106737, Chelatobacter heintzii, DSM 10368, DSM 7048, JCM 7852, KCTC 2477, LMG 2122, LMG:2122, NCCB 26039, NCIB 9039, NCIB:9039, NCIMB 9039, NCTC 10684, Pseudomonas aminovorans, VKM B-2058
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