STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
mymTMetallothionein, MymT; Metallothioneins are small proteins that have a high content of cysteine residues wich allow them to bind heavy metal ions through clusters of thiolate bonds. MymT binds up to seven ions of Cu(+), with a preference for four to six Cu(+) ions, in a solvent-shielded core. MymT protects M.tuberculosis from copper toxicity. (53 aa)    
Predicted Functional Partners:
ricR
Conserved protein; Under low copper conditions, represses the expression of lpqS, Rv2963, mymT, socA, socB, mmcO and its own expression. In the presence of copper, RicR dissociates from DNA, leading to the expression of the target genes. Members of the RicR regulon are important for copper resistance during infections and full virulence in a mouse model of infection.
      
 0.870
mmcO
Probable oxidase; Required for copper resistance. In vitro, oxidizes organic substrates and Fe(2+). May act in vivo by oxidation of toxic periplasmic Cu(+); Belongs to the multicopper oxidase family.
      
 0.870
lpqS
Probable lipoprotein LpqS; May play an essential role in M.tuberculosis replication and survival inside the host cell.
      
 0.870
Rv2963
Rv2963, (MTCY349.24c), len: 406 aa. Probable integral membrane protein.
      
 0.870
csoR
Copper-sensitive operon repressor CsoR; Copper-sensitive repressor that has a key role in copper homeostasis. It is part of the cso operon involved in the cellular response to increasing concentrations of copper inside the bacterium, which can be highly toxic. In the presence of copper, CsoR fully dissociates from the promoter in the cso operon, leading to the transcription of its genes. Binds to a GC-rich pseudopallindromic sequence, 5'-GTAGCCCACCCCCAGTGGGGTGGGA-3', in the cso promoter region.
      
 0.804
ctpV
Probable metal cation transporter P-type ATPase CtpV; Necessary for copper homeostasis and likely functions as a copper exporter. Also required for full virulence.
      
 0.655
Rv0187
Probable O-methyltransferase; Catechol O-methyltransferase that can use various catechol- like compounds such as gallic acid (GA), 3,4-dihydroxy-5-methoxy- benzoic acid (5OMeBA), protocatechuic acid (PCA), 3,4-dihydroxy- benzaldehyde (DHA), dopamine, caffeic acid (CA), luteolin, quercetin, and 5-hydroxyuridine; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.
       0.648
Rv2683
Conserved protein; Rv2683, (MTCY05A6.04), len: 165 aa. Conserved protein, equivalent, but shorter 19 aa, to Q49999|ML1037|U1764Q hypothetical protein from Mycobacterium leprae (184 aa), FASTA scores: opt: 750, E(): 1.2e-41, (73.8% identity in 164 aa overlap). Shows some similarity with other hypothetical proteins e.g. Q988S9|MLL6611 from Rhizobium loti (Mesorhizobium loti) (232 aa), FASTA scores: opt: 128, E(): 0.25, (25.5% identity in 149 aa overlap); Q9YFL5|APE0233 from Aeropyrum pernix (340 aa), FASTA scores: opt: 123, E(): 0.73, (29.1% identity in 141 aa overlap); BAB60477|TVG13777 [...]
      
 0.583
Rv0850
Rv0850, (MTV043.43), len: 110 aa. Putative transposase (fragment), similar in part to others e.g. Q45144|Q4514 transposable element IS31831 (436 aa), FASTA scores: opt: 175, E(): 4.3e-05, (38.6% identity in 57 aa overlap); etc.
      
 0.582
cysK2
S-sulfocysteine synthase; Catalyzes the synthesis of S-sulfocysteine, utilizing O- phosphoserine (OPS) and thiosulfate as substrates. To a lesser extent, can also use sulfide as donor substrate, producing L-cysteine. CysK2 thus provides a third metabolic route to cysteine, either directly using sulfide as donor or indirectly via S-sulfocysteine. S- sulfocysteine might also act as a signaling molecule triggering additional responses in redox defense in the pathogen upon exposure to reactive oxygen species during intracellular survival or dormancy. Cannot utilize thiocarboxylated CysO as [...]
      
 0.546
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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