Conserved protein; Oxidase that catalyzes the conversion of cysteine to 3- oxoalanine on target proteins. 3-oxoalanine modification, which is also named formylglycine (fGly), occurs in the maturation of arylsulfatases and some alkaline phosphatases that use the hydrated form of 3- oxoalanine as a catalytic nucleophile.

Conserved hypothetical protein; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA; Belongs to the RNase Z family.

Conserved protein; Bifunctional enzyme which has both oligoribonuclease and pAp- phosphatase activities. Degrades RNA oligonucleotides with a length of 5 nucleotides and shorter, with a preference for 2-mers. Also degrades 24-mers. Converts 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP.

Possible hydrolase; Rv3762c, (MTV025.110c), len: 626 aa. Possible hydrolase, highly similar to hypothetical proteins and beta-lactamases e.g. Q9RL04|SC5G9.23 hypothetical 70.3 KDA protein from Streptomyces coelicolor (648 aa), FASTA scores: opt: 2088, E(): 3.7e-124, (52.9% identity in 624 aa overlap); P32717|YJCS_ECOLI|B4083 hypothetical 73.2 KDA protein from Escherichia coli strain K12 (661 aa), FASTA scores: opt: 1911, E(): 5.7e-113, (46.9% identity in 631 aa overlap); Q9A824|CC1540 metallo-beta-lactamase family protein from Caulobacter crescentus (647 aa), FASTA scores: opt: 1891, E [...]

Possible transcriptional regulatory protein; Positively regulates the expression of PE13 and PPE18. Can also regulate expression of some other genes. Plays a role in modulation of innate immune responses; Belongs to the ROK (NagC/XylR) family.

Rv1730c, (MTCY04C12.15c), len: 517 aa. Possible penicillin-binding protein, similar to others e.g. PBP4_NOCLA|Q06317 penicillin-binding protein 4 (pbp-4) from Nocardia lactamdurans (381 aa), FASTA scores: opt: 643,E(): 3.8e-32, (33.8% identity in 370 aa overlap); etc. Also similar to other Mycobacterium tuberculosis hypothetical penicillin binding proteins and esterases e.g. Rv1923,Rv1497, etc.

Probable glycine dehydrogenase GcvB (glycine decarboxylase) (glycine cleavage system P-protein); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (By similarity); Belongs to the GcvP family.

Probable phosphoglycerate mutase 1 Gpm1 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM); Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily.

Rv1714, (MTV048.01), len: 270 aa. Probable oxidoreductase similar to many e.g. AE0010|AE001021_4 Archaeoglobus fulgidus section 79 (281 aa), FASTA scores: opt: 578, E(): 3.3e-31, (38.9% identity in 265 aa overlap). Also similar to several other M. tuberculosis oxidoreductases e.g. Rv1544, etc.