node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
vapB29 | vapB34 | Rv0616A | Rv1740 | Possible antitoxin VapB29; Possibly the antitoxic component of a type II toxin-antitoxin (TA) system. Its cognate toxin is VapC29. | Possible antitoxin VapB34; Antitoxin component of a possible type II toxin-antitoxin (TA) system. The cognate toxin is VapC34. | 0.549 |
vapB29 | vapB4 | Rv0616A | Rv0596c | Possible antitoxin VapB29; Possibly the antitoxic component of a type II toxin-antitoxin (TA) system. Its cognate toxin is VapC29. | Possible antitoxin VapB4; Antitoxin component of a type II toxin-antitoxin (TA) system. Antitoxin that counteracts the effect of its cognate VapC4 toxin. Upon expression in situ, in M.smegmatis or E.coli neutralizes the effect of cognate toxin VapC4. | 0.548 |
vapB29 | vapB49 | Rv0616A | Rv3181c | Possible antitoxin VapB29; Possibly the antitoxic component of a type II toxin-antitoxin (TA) system. Its cognate toxin is VapC29. | Conserved protein; Possibly the antitoxin component of a type II toxin-antitoxin (TA) system. Its cognate toxin is VapC49 (Potential). | 0.630 |
vapB29 | vapC23 | Rv0616A | Rv2863 | Possible antitoxin VapB29; Possibly the antitoxic component of a type II toxin-antitoxin (TA) system. Its cognate toxin is VapC29. | Possible toxin VapC23; Toxic component of a type II toxin-antitoxin (TA) system. An RNase. The cognate antitoxin is VapB23 (By similarity). Belongs to the PINc/VapC protein family. | 0.664 |
vapB29 | vapC4 | Rv0616A | Rv0595c | Possible antitoxin VapB29; Possibly the antitoxic component of a type II toxin-antitoxin (TA) system. Its cognate toxin is VapC29. | Possible toxin VapC4; Toxic component of a type II toxin-antitoxin (TA) system. Probably exerts its toxic effect by binding to mRNA, inhibiting translation. Binds to, recognizes and cleaves ssRNA at ACGC and AC(A/U)GC sequences, usually between the G and C; cleavage is not very efficient, nor is cleavage required to inhibit protein synthesis. Upon expression in situ, in M.smegmatis or E.coli inhibits cell growth and colony formation; in at least E.coli also causes increased levels of cellular RNA. Its toxic effect is neutralized by coexpression with cognate antitoxin VapB4. | 0.624 |
vapB29 | vapC47 | Rv0616A | Rv3408 | Possible antitoxin VapB29; Possibly the antitoxic component of a type II toxin-antitoxin (TA) system. Its cognate toxin is VapC29. | Possible toxin VapC47. Contains PIN domain; Toxic component of a type II toxin-antitoxin (TA) system. An RNase (By similarity). Upon expression in M.smegmatis inhibits translation and colony formation. Its toxic effect on colony formation is neutralized by coexpression with cognate antitoxin VapB47; the effect on translation has not been tested but is probably neutralized also.; Belongs to the PINc/VapC protein family. | 0.635 |
vapB29 | vapC49 | Rv0616A | Rv3180c | Possible antitoxin VapB29; Possibly the antitoxic component of a type II toxin-antitoxin (TA) system. Its cognate toxin is VapC29. | Hypothetical alanine rich protein; Toxic component of a type II toxin-antitoxin (TA) system. An RNase. Its cognate antitoxin is VapB49 (By similarity). | 0.638 |
vapB34 | vapB29 | Rv1740 | Rv0616A | Possible antitoxin VapB34; Antitoxin component of a possible type II toxin-antitoxin (TA) system. The cognate toxin is VapC34. | Possible antitoxin VapB29; Possibly the antitoxic component of a type II toxin-antitoxin (TA) system. Its cognate toxin is VapC29. | 0.549 |
vapB34 | vapB4 | Rv1740 | Rv0596c | Possible antitoxin VapB34; Antitoxin component of a possible type II toxin-antitoxin (TA) system. The cognate toxin is VapC34. | Possible antitoxin VapB4; Antitoxin component of a type II toxin-antitoxin (TA) system. Antitoxin that counteracts the effect of its cognate VapC4 toxin. Upon expression in situ, in M.smegmatis or E.coli neutralizes the effect of cognate toxin VapC4. | 0.628 |
vapB34 | vapB49 | Rv1740 | Rv3181c | Possible antitoxin VapB34; Antitoxin component of a possible type II toxin-antitoxin (TA) system. The cognate toxin is VapC34. | Conserved protein; Possibly the antitoxin component of a type II toxin-antitoxin (TA) system. Its cognate toxin is VapC49 (Potential). | 0.520 |
vapB34 | vapC23 | Rv1740 | Rv2863 | Possible antitoxin VapB34; Antitoxin component of a possible type II toxin-antitoxin (TA) system. The cognate toxin is VapC34. | Possible toxin VapC23; Toxic component of a type II toxin-antitoxin (TA) system. An RNase. The cognate antitoxin is VapB23 (By similarity). Belongs to the PINc/VapC protein family. | 0.653 |
vapB34 | vapC4 | Rv1740 | Rv0595c | Possible antitoxin VapB34; Antitoxin component of a possible type II toxin-antitoxin (TA) system. The cognate toxin is VapC34. | Possible toxin VapC4; Toxic component of a type II toxin-antitoxin (TA) system. Probably exerts its toxic effect by binding to mRNA, inhibiting translation. Binds to, recognizes and cleaves ssRNA at ACGC and AC(A/U)GC sequences, usually between the G and C; cleavage is not very efficient, nor is cleavage required to inhibit protein synthesis. Upon expression in situ, in M.smegmatis or E.coli inhibits cell growth and colony formation; in at least E.coli also causes increased levels of cellular RNA. Its toxic effect is neutralized by coexpression with cognate antitoxin VapB4. | 0.803 |
vapB34 | vapC47 | Rv1740 | Rv3408 | Possible antitoxin VapB34; Antitoxin component of a possible type II toxin-antitoxin (TA) system. The cognate toxin is VapC34. | Possible toxin VapC47. Contains PIN domain; Toxic component of a type II toxin-antitoxin (TA) system. An RNase (By similarity). Upon expression in M.smegmatis inhibits translation and colony formation. Its toxic effect on colony formation is neutralized by coexpression with cognate antitoxin VapB47; the effect on translation has not been tested but is probably neutralized also.; Belongs to the PINc/VapC protein family. | 0.516 |
vapB34 | vapC49 | Rv1740 | Rv3180c | Possible antitoxin VapB34; Antitoxin component of a possible type II toxin-antitoxin (TA) system. The cognate toxin is VapC34. | Hypothetical alanine rich protein; Toxic component of a type II toxin-antitoxin (TA) system. An RNase. Its cognate antitoxin is VapB49 (By similarity). | 0.518 |
vapB4 | vapB29 | Rv0596c | Rv0616A | Possible antitoxin VapB4; Antitoxin component of a type II toxin-antitoxin (TA) system. Antitoxin that counteracts the effect of its cognate VapC4 toxin. Upon expression in situ, in M.smegmatis or E.coli neutralizes the effect of cognate toxin VapC4. | Possible antitoxin VapB29; Possibly the antitoxic component of a type II toxin-antitoxin (TA) system. Its cognate toxin is VapC29. | 0.548 |
vapB4 | vapB34 | Rv0596c | Rv1740 | Possible antitoxin VapB4; Antitoxin component of a type II toxin-antitoxin (TA) system. Antitoxin that counteracts the effect of its cognate VapC4 toxin. Upon expression in situ, in M.smegmatis or E.coli neutralizes the effect of cognate toxin VapC4. | Possible antitoxin VapB34; Antitoxin component of a possible type II toxin-antitoxin (TA) system. The cognate toxin is VapC34. | 0.628 |
vapB4 | vapB49 | Rv0596c | Rv3181c | Possible antitoxin VapB4; Antitoxin component of a type II toxin-antitoxin (TA) system. Antitoxin that counteracts the effect of its cognate VapC4 toxin. Upon expression in situ, in M.smegmatis or E.coli neutralizes the effect of cognate toxin VapC4. | Conserved protein; Possibly the antitoxin component of a type II toxin-antitoxin (TA) system. Its cognate toxin is VapC49 (Potential). | 0.515 |
vapB4 | vapC14 | Rv0596c | Rv1953 | Possible antitoxin VapB4; Antitoxin component of a type II toxin-antitoxin (TA) system. Antitoxin that counteracts the effect of its cognate VapC4 toxin. Upon expression in situ, in M.smegmatis or E.coli neutralizes the effect of cognate toxin VapC4. | Possible toxin VapC14; Toxic component of a type II toxin-antitoxin (TA) system. An RNase. The cognate antitoxin is VapB14 (By similarity); Belongs to the PINc/VapC protein family. | 0.529 |
vapB4 | vapC23 | Rv0596c | Rv2863 | Possible antitoxin VapB4; Antitoxin component of a type II toxin-antitoxin (TA) system. Antitoxin that counteracts the effect of its cognate VapC4 toxin. Upon expression in situ, in M.smegmatis or E.coli neutralizes the effect of cognate toxin VapC4. | Possible toxin VapC23; Toxic component of a type II toxin-antitoxin (TA) system. An RNase. The cognate antitoxin is VapB23 (By similarity). Belongs to the PINc/VapC protein family. | 0.631 |
vapB4 | vapC4 | Rv0596c | Rv0595c | Possible antitoxin VapB4; Antitoxin component of a type II toxin-antitoxin (TA) system. Antitoxin that counteracts the effect of its cognate VapC4 toxin. Upon expression in situ, in M.smegmatis or E.coli neutralizes the effect of cognate toxin VapC4. | Possible toxin VapC4; Toxic component of a type II toxin-antitoxin (TA) system. Probably exerts its toxic effect by binding to mRNA, inhibiting translation. Binds to, recognizes and cleaves ssRNA at ACGC and AC(A/U)GC sequences, usually between the G and C; cleavage is not very efficient, nor is cleavage required to inhibit protein synthesis. Upon expression in situ, in M.smegmatis or E.coli inhibits cell growth and colony formation; in at least E.coli also causes increased levels of cellular RNA. Its toxic effect is neutralized by coexpression with cognate antitoxin VapB4. | 0.985 |