STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Rv0690cRv0690c, (MTCY210.07c), len: 349 aa. Conserved hypothetical protein, showing similarity with NP_386956.1|NC_003047 conserved hypothetical protein from Sinorhizobium meliloti (358 aa); NP_356573.1|NC_003063 AGR_L_1570p from Agrobacterium tumefaciens (346 aa); NP_421938.1|NC_002696 conserved hypothetical protein from Caulobacter crescentus (370 aa). (349 aa)    
Predicted Functional Partners:
mftR
Probable transcriptional regulatory protein; May regulate a gene cluster involved in mycofactocin expression. Mycofactocin is a conserved polypeptide that might serve as an electron carrier.
  
    0.882
mftF
Probable membrane sugar transferase; May play a role in the maturation of mycofactocin, a conserved polypeptide that might serve as an electron carrier. The genes for mycofactocin and other proteins proposed to function in its maturation are found in a conserved gene cluster; Belongs to the glycosyltransferase 2 family.
  
    0.638
pqqE
Probable coenzyme PQQ synthesis protein E PqqE (coenzyme PQQ synthesis protein III); May function to modify mycofactocin, a conserved polypeptide that might serve as an electron carrier. The genes for mycofactocin and other proteins proposed to function in its maturation are found in a conserved gene cluster; Belongs to the radical SAM superfamily.
  
    0.621
lldD1
Possible L-lactate dehydrogenase (cytochrome) LldD1; May play a role in the maturation of mycofactocin, a conserved polypeptide that might serve as an electron carrier. The genes for mycofactocin and other proteins proposed to function in its maturation are found in a conserved gene cluster; Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.
  
    0.616
mftB
Conserved hypothetical protein; May function to bind or modify mycofactocin, a conserved polypeptide that might serve as an electron carrier. The genes for mycofactocin and other proteins proposed to function in its maturation are found in a conserved gene cluster.
  
    0.608
pth
Probable peptidyl-tRNA hydrolase Pth; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family.
      0.574
mftA
Mycofactocin precursor protein; A putative polypeptide that may function as an electron carrier; the C-terminal 8 residues are highly conserved. The genes for mycofactocin and other proteins proposed to function in its maturation are found in a conserved gene cluster.
       0.573
Rv1006
Unknown protein; Rv1006, (MTCI237.23), len: 567 aa. Unknown protein. Predicted to be an outer membrane protein (See Song et al.,2008).
  
    0.557
Rv1868
Rv1868, (MTCY359.05c), len: 699 aa. Conserved hypothetical protein, similar to products of three consecutive ORFS in Mycobacterium leprae MLCB2052.18|Z98604|B2052 (257 aa), FASTA scores: opt: 314,E(): 9.9e-12, (35.2% identity in 213 aa overlap); MLCB2052.17, and MLCB2052.16. Also similar to M. tuberculosis hypothetical protein Rv2047c.
  
    0.556
mftE
Conserved hypothetical protein; May play a role in the maturation of mycofactocin, a conserved polypeptide that might serve as an electron carrier. The genes for mycofactocin and other proteins proposed to function in its maturation are found in a conserved gene cluster.
  
    0.545
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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