Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
Rv0887cRv0887c, (MTCY31.15c), len: 152 aa. Conserved hypothetical protein, highly similar to others e.g. NP_436346.1|NC_003037 Hypothetical protein from Sinorhizobium meliloti (149 aa); AL132644|SCI8_26 hypothetical protein from Streptomyces coelicolor (194 aa),FASTA scores: opt: 220, E(): 1.5e-07, (33.6% identity in 131 aa overlap); etc. Also shows weak similarity with transposases and related proteins. (152 aa)    
Predicted Functional Partners:
Rv0654
Probable dioxygenase; Catalyzes the oxidative cleavage of several carotenoids and apocarotenoids in vitro. In contrast to other carotenoid oxygenases, cleaves substrates at two different sites, namely the central C15-C15' and an excentric double bond at the C13-C14 position, leading to retinal (C20), beta-apo-14'-carotenal (C22) and beta-apo-13-carotenone (C18) from beta-carotene (C40), as well as the corresponding hydroxylated products from zeaxanthin and lutein. Converts beta-apo- 10'-carotenal (C27) into beta-apo-13-carotenone (C18) and to minor amounts of beta-apo-15-carotenal (ret [...]
      
 0.890
Rv0911
Conserved protein; Rv0911, (MTCY21C12.05), len: 257 aa. Conserved protein, showing similarity with hydroxylases and hypothetical proteins e.g. T35325 probable hydroxylase from Streptomyces coelicolor (265 aa); Q54242 hypothetical protein from Streptomyces, FASTA scores: opt: 372, E(): 8.8e-18, (32.0% identity in 256 aa overlap); AAD04716.1|U77891 doxorubicin biosynthesis enzyme DnrV from Streptomyces peucetius (275 aa); AAA63051.1|U15184 hypothetical protein from Mycobacterium leprae (94 aa); etc. Also similar to Rv0577 hypothetical protein from Mycobacterium tuberculosis (261 aa).
  
  
 0.886
Rv1931c
Probable transcriptional regulatory protein; Controls the expression of genes important for virulence.
 
    0.859
Rv0181c
Conserved hypothetical protein; Putative quercetin 2,3-dioxygenase; Belongs to the pirin family.
 
   
 0.853
Rv1190
Rv1190, (MTCI364.02), len: 292 aa. Conserved hypothetical protein, similar to Rv1833c|Y0DA_MYCTU|Q50600 hypothetical 32.2 kDa protein cy1a11.10 (286 aa), fasta scores: opt: 331, E(): 1.4e-15, (29.0% identity in 272 aa overlap), also YU14_MYCTU|Q50670 putative haloalkane dehalogenase (300 aa), FASTA scores: opt: 239, E(): 2.2e-09, (29.9% identity in 298 aa overlap).
  
  
 0.836
Rv1725c
Conserved hypothetical protein; Rv1725c, (MTCY04C12.10c), len: 236 aa. Conserved hypothetical protein, similar to other hypothetical proteins from diverse organisms e.g. P70885|U44893 ORF108 from butyrivibrio fibrisolvens, (108 aa), FASTA scores: opt: 223, E(): 2e-09, (39.1% identity in 92 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical transcriptional regulator, O05774|Rv3095|YU95_MYCTU (158 aa).
 
    0.834
sigI
Possible alternative RNA polymerase sigma factor SigI; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Extracytoplasmic function (ECF) sigma factors are held in an inactive form by a cognate anti-sigma factor until released, although no anti-sigma factor is known for this protein (By similarity).
  
    0.831
Rv0912
Rv0912, (MTCY21C12.06), len: 149 aa. Probable conserved transmembrane protein, equivalent to Q50121|NP_302397.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (144 aa), FASTA scores: opt: 677,E(): 6.9e-38, (69.5% identity in 141 aa overlap). A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004).
      
 0.830
Rv0942
Hypothetical protein; Rv0942, (MTCY10D7.32c), len: 92 aa. Hypothetical unknown protein.
      
 0.829
virS
Virulence-regulating transcriptional regulator VirS (AraC/XylS family); Regulates the expression of the mymA operon (Rv3083-Rv3089).
 
    0.820
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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