STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Rv0923cConserved hypothetical protein; Rv0923c, (MTCY21C12.17c), len: 354 aa. Conserved hypothetical protein, showing similarity with C-terminal part of AF034138|AF034138_7|yjoB hypothetical protein from Bacillus subtilis (200 aa), FASTA scores: opt: 193, E(): 4.2e-05, (32.3% identity in 167 aa overlap). (354 aa)    
Predicted Functional Partners:
mntH
Divalent cation-transport integral membrane protein MntH (BRAMP) (MRAMP); H(+)-stimulated, divalent metal cation uptake system. Transports zinc and iron. Can also interact with manganese and copper.
  
    0.887
Rv0925c
Conserved protein; Rv0925c, (MTCY21C12.19c), len: 245 aa. Conserved protein, similar to AL132991|SCF55_19 hypothetical protein from Streptomyces coelicolor (197 aa), FASTA scores: opt: 459, E(): 1.2e-23, (39.3% identity in 201 aa overlap).
  
    0.710
Rv2079
Rv2079, (MTCY49.18), len: 656 aa. Conserved hypothetical protein; part of Mycobacterium tuberculosis protein family with Rv2542, Rv2077c, Rv2797c, Rv0963c,Rv1949c. Contains PS00120 Lipases, serine active site.
  
    0.608
Rv2423
Hypothetical protein; Rv2423, (MTCY428.24c), len: 348 aa. Hypothetical unknown protein.
  
     0.596
mbtK
Lysine N-acetyltransferase MbtK; Acyltransferase required for the direct transfer of medium- to long-chain fatty acyl moieties from a carrier protein (MbtL) on to the epsilon-amino group of lysine residue in the mycobactin core.
  
     0.575
Rv3899c
Rv3899c, (MTCY15F10.13), len: 410 aa. Conserved hypothetical protein, similar in part to proteins from Mycobacterium tuberculosis strains H37Rv and CDC1551. Region between aa 29-80 is strictly identical to P96909 hypothetical 15.1 KDA protein (fragment) (143 aa) FASTA scores: opt: 562, E(): 4e-16, (69.0% identity in 142 aa overlap); and the N-terminal end is highly similar, but longer 65 aa, to O07266 hypothetical 13.7 KDA protein (fragment) (143 aa), FASTA scores: opt: 562, E(): 4e-16,(69.0% identity in 142 aa overlap). Highly similar to C-terminal end of Q10690|YK82_MYCTU|Rv2082|MTCY [...]
  
    0.565
eccD2
ESX-2 secretion system protein eccD2; Rv3887c, (MTCY15F10.25), len: 509 aa. eccD2, esx conserved component, ESX-2 type VII secretion system protein, probable transmembrane protein (has hydrophilic stretch from ~1-130 then very hydrophobic domain), similar to other membrane proteins and with weak similarity to known transporters, e.g. Q9CBV2|ML1539 probable membrane protein from Mycobacterium leprae (503 aa), FASTA scores: opt: 395, E(): 2.3e-16, (28.0% identity in 496 aa overlap); Q9CD35|ML2529 conserved membrane protein from Mycobacterium leprae (485 aa), FASTA scores: opt: 221, E(): [...]
  
     0.554
Rv1904
Rv1904, (MTCY180.14c), len: 143 aa. Conserved hypothetical protein, some similarity to other hypothetical Mycobacterium tuberculosis proteins e.g. Rv2638|MTCY441.08|P71937 (148 aa), FASTA results: opt: 456,E(): 2.7e-23, (52.8% identity in 125 aa overlap); Rv1365|Q11035 (128 aa), FASTA results: opt: 393, E(): 1.4e-19, (48.8% identity in 123 aa overlap); and Rv3687c. Also weak similarity to Q9WVX8|RSBV_STRCO anti-sigma B factor antagonist from Streptomyces coelicolor (113 aa).
  
    0.543
Rv0926c
Conserved hypothetical protein; Rv0926c, (MTCY21C12.20c), len: 358 aa. Conserved hypothetical protein, similar to Rv1059 conserved hypothetical protein from Mycobacterium tuberculosis (354 aa). Also shows some similarity to AF170923|AF170923_3 dihydrodipicolinate reductase from Mastigocladus laminosus (278 aa), FASTA scores: opt: 170, E(): 0.00088, (25.7% identity in 276 aa overlap).
  
    0.516
eccD5
ESX conserved component EccD5. ESX-5 type VII secretion system protein. Probable membrane protein; Part of the ESX-5 specialized secretion system, which is responsible for the secretion of EsxN and a number of PE_PGRS and PPE proteins, including PPE41.
  
    0.503
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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