node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rv1106c | Rv1109c | Rv1106c | Rv1109c | 3-beta-hydroxysteroid dehydrogenase; 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidation and isomerization of cholesterol, pregnenolone, and dehydroepiandrosterone (DHEA) into cholest-4-en-3-one, progesterone, and androsterone, respectively. | Conserved protein; Rv1109c, (MTV017.62c), len: 212 aa. Conserved protein. Equivalent to AL049491|MLCB1222_4 hypothetical protein from Mycobacterium leprae (205 aa) (68.1% identity in 213 aa overlap). A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004). | 0.882 |
Rv1106c | choD | Rv1106c | Rv3409c | 3-beta-hydroxysteroid dehydrogenase; 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidation and isomerization of cholesterol, pregnenolone, and dehydroepiandrosterone (DHEA) into cholest-4-en-3-one, progesterone, and androsterone, respectively. | Cholesterol oxidase ChoD (cholesterol-O2 oxidoreductase); Catalyzes the oxidation and isomerization of cholesterol to cholestenone (4-cholesten-3-one), which is an initial step in the cholesterol degradation process. Required for virulence. Belongs to the GMC oxidoreductase family. Highly divergent. | 0.987 |
Rv1106c | cyp125 | Rv1106c | Rv3545c | 3-beta-hydroxysteroid dehydrogenase; 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidation and isomerization of cholesterol, pregnenolone, and dehydroepiandrosterone (DHEA) into cholest-4-en-3-one, progesterone, and androsterone, respectively. | Probable cytochrome P450 125 Cyp125; Involved in the utilization of cholesterol as the sole carbon and energy source by degrading the side chain during infection. Primarily catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25S)-26- hydroxycholest-4-en-3-one (alcohol), (25S)-26-oxocholest-4-en-3-one (aldehyde), to finally yield the carboxylic acid (25S)-3-oxocholest-4- en-26-oate. Also able to sequentially oxidize cholesterol itself, not only cholest-4-en- 3-one. Belongs to the cytochrome P450 family. | 0.960 |
Rv1106c | cyp142 | Rv1106c | Rv3518c | 3-beta-hydroxysteroid dehydrogenase; 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidation and isomerization of cholesterol, pregnenolone, and dehydroepiandrosterone (DHEA) into cholest-4-en-3-one, progesterone, and androsterone, respectively. | Probable cytochrome P450 monooxygenase 142 Cyp142; Involved in the utilization of cholesterol as the sole carbon and energy source by degrading the side chain during infection. Primarily catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25R)-26-hydroxycholest-4- en-3-one (alcohol), (25R)-26-oxocholest-4-en-3-one (aldehyde), to finally yield the carboxylic acid (25R)-3-oxocholest-4-en-26-oate. In vitro, Cyp142 catalyzes with equal preference the oxidation of both (25R)- and (25S)-26- hydroxycholest-4-en-3-one diastereomers to the corresponding carboxy [...] | 0.968 |
Rv1106c | rpsC | Rv1106c | Rv0707 | 3-beta-hydroxysteroid dehydrogenase; 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidation and isomerization of cholesterol, pregnenolone, and dehydroepiandrosterone (DHEA) into cholest-4-en-3-one, progesterone, and androsterone, respectively. | 30S ribosomal protein S3 RpsC; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. | 0.803 |
Rv1106c | rpsL | Rv1106c | Rv0682 | 3-beta-hydroxysteroid dehydrogenase; 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidation and isomerization of cholesterol, pregnenolone, and dehydroepiandrosterone (DHEA) into cholest-4-en-3-one, progesterone, and androsterone, respectively. | 30S ribosomal protein S12 RpsL; With S4 and S5 plays an important role in translational accuracy. | 0.814 |
Rv1106c | rpsQ | Rv1106c | Rv0710 | 3-beta-hydroxysteroid dehydrogenase; 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidation and isomerization of cholesterol, pregnenolone, and dehydroepiandrosterone (DHEA) into cholest-4-en-3-one, progesterone, and androsterone, respectively. | 30S ribosomal protein S17 RpsQ; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. | 0.804 |
Rv1106c | rpsS | Rv1106c | Rv0705 | 3-beta-hydroxysteroid dehydrogenase; 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidation and isomerization of cholesterol, pregnenolone, and dehydroepiandrosterone (DHEA) into cholest-4-en-3-one, progesterone, and androsterone, respectively. | 30S ribosomal protein S19 RpsS; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. | 0.817 |
Rv1106c | xseA | Rv1106c | Rv1108c | 3-beta-hydroxysteroid dehydrogenase; 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidation and isomerization of cholesterol, pregnenolone, and dehydroepiandrosterone (DHEA) into cholest-4-en-3-one, progesterone, and androsterone, respectively. | Probable exodeoxyribonuclease VII (large subunit) XseA (exonuclease VII large subunit); Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. | 0.883 |
Rv1106c | xseB | Rv1106c | Rv1107c | 3-beta-hydroxysteroid dehydrogenase; 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidation and isomerization of cholesterol, pregnenolone, and dehydroepiandrosterone (DHEA) into cholest-4-en-3-one, progesterone, and androsterone, respectively. | Probable exodeoxyribonuclease VII (small subunit) XseB (exonuclease VII small subunit); Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. | 0.888 |
Rv1109c | Rv1106c | Rv1109c | Rv1106c | Conserved protein; Rv1109c, (MTV017.62c), len: 212 aa. Conserved protein. Equivalent to AL049491|MLCB1222_4 hypothetical protein from Mycobacterium leprae (205 aa) (68.1% identity in 213 aa overlap). A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004). | 3-beta-hydroxysteroid dehydrogenase; 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidation and isomerization of cholesterol, pregnenolone, and dehydroepiandrosterone (DHEA) into cholest-4-en-3-one, progesterone, and androsterone, respectively. | 0.882 |
Rv1109c | xseA | Rv1109c | Rv1108c | Conserved protein; Rv1109c, (MTV017.62c), len: 212 aa. Conserved protein. Equivalent to AL049491|MLCB1222_4 hypothetical protein from Mycobacterium leprae (205 aa) (68.1% identity in 213 aa overlap). A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004). | Probable exodeoxyribonuclease VII (large subunit) XseA (exonuclease VII large subunit); Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. | 0.886 |
Rv1109c | xseB | Rv1109c | Rv1107c | Conserved protein; Rv1109c, (MTV017.62c), len: 212 aa. Conserved protein. Equivalent to AL049491|MLCB1222_4 hypothetical protein from Mycobacterium leprae (205 aa) (68.1% identity in 213 aa overlap). A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004). | Probable exodeoxyribonuclease VII (small subunit) XseB (exonuclease VII small subunit); Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. | 0.886 |
choD | Rv1106c | Rv3409c | Rv1106c | Cholesterol oxidase ChoD (cholesterol-O2 oxidoreductase); Catalyzes the oxidation and isomerization of cholesterol to cholestenone (4-cholesten-3-one), which is an initial step in the cholesterol degradation process. Required for virulence. Belongs to the GMC oxidoreductase family. Highly divergent. | 3-beta-hydroxysteroid dehydrogenase; 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidation and isomerization of cholesterol, pregnenolone, and dehydroepiandrosterone (DHEA) into cholest-4-en-3-one, progesterone, and androsterone, respectively. | 0.987 |
choD | cyp125 | Rv3409c | Rv3545c | Cholesterol oxidase ChoD (cholesterol-O2 oxidoreductase); Catalyzes the oxidation and isomerization of cholesterol to cholestenone (4-cholesten-3-one), which is an initial step in the cholesterol degradation process. Required for virulence. Belongs to the GMC oxidoreductase family. Highly divergent. | Probable cytochrome P450 125 Cyp125; Involved in the utilization of cholesterol as the sole carbon and energy source by degrading the side chain during infection. Primarily catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25S)-26- hydroxycholest-4-en-3-one (alcohol), (25S)-26-oxocholest-4-en-3-one (aldehyde), to finally yield the carboxylic acid (25S)-3-oxocholest-4- en-26-oate. Also able to sequentially oxidize cholesterol itself, not only cholest-4-en- 3-one. Belongs to the cytochrome P450 family. | 0.933 |
choD | cyp142 | Rv3409c | Rv3518c | Cholesterol oxidase ChoD (cholesterol-O2 oxidoreductase); Catalyzes the oxidation and isomerization of cholesterol to cholestenone (4-cholesten-3-one), which is an initial step in the cholesterol degradation process. Required for virulence. Belongs to the GMC oxidoreductase family. Highly divergent. | Probable cytochrome P450 monooxygenase 142 Cyp142; Involved in the utilization of cholesterol as the sole carbon and energy source by degrading the side chain during infection. Primarily catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25R)-26-hydroxycholest-4- en-3-one (alcohol), (25R)-26-oxocholest-4-en-3-one (aldehyde), to finally yield the carboxylic acid (25R)-3-oxocholest-4-en-26-oate. In vitro, Cyp142 catalyzes with equal preference the oxidation of both (25R)- and (25S)-26- hydroxycholest-4-en-3-one diastereomers to the corresponding carboxy [...] | 0.944 |
cyp125 | Rv1106c | Rv3545c | Rv1106c | Probable cytochrome P450 125 Cyp125; Involved in the utilization of cholesterol as the sole carbon and energy source by degrading the side chain during infection. Primarily catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25S)-26- hydroxycholest-4-en-3-one (alcohol), (25S)-26-oxocholest-4-en-3-one (aldehyde), to finally yield the carboxylic acid (25S)-3-oxocholest-4- en-26-oate. Also able to sequentially oxidize cholesterol itself, not only cholest-4-en- 3-one. Belongs to the cytochrome P450 family. | 3-beta-hydroxysteroid dehydrogenase; 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidation and isomerization of cholesterol, pregnenolone, and dehydroepiandrosterone (DHEA) into cholest-4-en-3-one, progesterone, and androsterone, respectively. | 0.960 |
cyp125 | choD | Rv3545c | Rv3409c | Probable cytochrome P450 125 Cyp125; Involved in the utilization of cholesterol as the sole carbon and energy source by degrading the side chain during infection. Primarily catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25S)-26- hydroxycholest-4-en-3-one (alcohol), (25S)-26-oxocholest-4-en-3-one (aldehyde), to finally yield the carboxylic acid (25S)-3-oxocholest-4- en-26-oate. Also able to sequentially oxidize cholesterol itself, not only cholest-4-en- 3-one. Belongs to the cytochrome P450 family. | Cholesterol oxidase ChoD (cholesterol-O2 oxidoreductase); Catalyzes the oxidation and isomerization of cholesterol to cholestenone (4-cholesten-3-one), which is an initial step in the cholesterol degradation process. Required for virulence. Belongs to the GMC oxidoreductase family. Highly divergent. | 0.933 |
cyp125 | cyp142 | Rv3545c | Rv3518c | Probable cytochrome P450 125 Cyp125; Involved in the utilization of cholesterol as the sole carbon and energy source by degrading the side chain during infection. Primarily catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25S)-26- hydroxycholest-4-en-3-one (alcohol), (25S)-26-oxocholest-4-en-3-one (aldehyde), to finally yield the carboxylic acid (25S)-3-oxocholest-4- en-26-oate. Also able to sequentially oxidize cholesterol itself, not only cholest-4-en- 3-one. Belongs to the cytochrome P450 family. | Probable cytochrome P450 monooxygenase 142 Cyp142; Involved in the utilization of cholesterol as the sole carbon and energy source by degrading the side chain during infection. Primarily catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25R)-26-hydroxycholest-4- en-3-one (alcohol), (25R)-26-oxocholest-4-en-3-one (aldehyde), to finally yield the carboxylic acid (25R)-3-oxocholest-4-en-26-oate. In vitro, Cyp142 catalyzes with equal preference the oxidation of both (25R)- and (25S)-26- hydroxycholest-4-en-3-one diastereomers to the corresponding carboxy [...] | 0.943 |
cyp142 | Rv1106c | Rv3518c | Rv1106c | Probable cytochrome P450 monooxygenase 142 Cyp142; Involved in the utilization of cholesterol as the sole carbon and energy source by degrading the side chain during infection. Primarily catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25R)-26-hydroxycholest-4- en-3-one (alcohol), (25R)-26-oxocholest-4-en-3-one (aldehyde), to finally yield the carboxylic acid (25R)-3-oxocholest-4-en-26-oate. In vitro, Cyp142 catalyzes with equal preference the oxidation of both (25R)- and (25S)-26- hydroxycholest-4-en-3-one diastereomers to the corresponding carboxy [...] | 3-beta-hydroxysteroid dehydrogenase; 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidation and isomerization of cholesterol, pregnenolone, and dehydroepiandrosterone (DHEA) into cholest-4-en-3-one, progesterone, and androsterone, respectively. | 0.968 |