node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PE_PGRS6 | Rv1265 | Rv0532 | Rv1265 | PE-PGRS family protein PE_PGRS6; Rv0532, (MTCY25D10.11), len: 594 aa. PE_PGRS6,Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citation below),similar to others e.g. Y0DP_MYCTU|Q50615 from Mycobacterium tuberculosis (498 aa), FASTA scores: opt: 1703, E(): 0,(58.2% identity in 536 aa overlap). | Unknown protein; Rv1265, (MTCY50.17c), len: 226 aa. Unknown protein (see citation below). | 0.511 |
PE_PGRS6 | Rv2971 | Rv0532 | Rv2971 | PE-PGRS family protein PE_PGRS6; Rv0532, (MTCY25D10.11), len: 594 aa. PE_PGRS6,Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citation below),similar to others e.g. Y0DP_MYCTU|Q50615 from Mycobacterium tuberculosis (498 aa), FASTA scores: opt: 1703, E(): 0,(58.2% identity in 536 aa overlap). | Rv2971, (MTCY349.16c), len: 282 aa. Probable oxidoreductase, possibly aldo/keto reductase, equivalent to O69462 putative oxidoreductase from Mycobacterium leprae (282 aa), FASTA scores: opt: 1495, E(): 4.9e-93, (82.35% identity in 272 aa overlap). Also similar to others e.g. Q9KYM9|SC9H11.10C oxidoreductase from Streptomyces coelicolor (276 aa), FASTA scores: opt: 849, E(): 1.2e-49,(51.7% identity in 267 aa overlap); Q9ZBW7|SC4B5.01C putative oxidoreductase from Streptomyces coelicolor (277 aa), FASTA scores: opt: 847, E(): 1.7e-49, (49.1% identity in 271 aa overlap); Q46857|YQHE_ECOLI [...] | 0.528 |
PE_PGRS6 | cmr | Rv0532 | Rv1675c | PE-PGRS family protein PE_PGRS6; Rv0532, (MTCY25D10.11), len: 594 aa. PE_PGRS6,Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citation below),similar to others e.g. Y0DP_MYCTU|Q50615 from Mycobacterium tuberculosis (498 aa), FASTA scores: opt: 1703, E(): 0,(58.2% identity in 536 aa overlap). | Probable transcriptional regulatory protein Cmr; Positively regulates the expression of at least groEL2. Cyclic AMP does not affect transcription in vitro. | 0.517 |
Rv0898c | Rv1265 | Rv0898c | Rv1265 | Rv0898c, (MTCY31.26c), len: 87 aa. Conserved hypothetical protein, highly similar to CAC01589.1|AL391041 hypothetical protein from Streptomyces coelicolor (87 aa). Also shows some similarity to Rv0709|MTCY210.28|rpmC from Mycobacterium tuberculosis (77 aa), FASTA score: (28.8% identity in 73 aa overlap). | Unknown protein; Rv1265, (MTCY50.17c), len: 226 aa. Unknown protein (see citation below). | 0.468 |
Rv0898c | rsfB | Rv0898c | Rv3687c | Rv0898c, (MTCY31.26c), len: 87 aa. Conserved hypothetical protein, highly similar to CAC01589.1|AL391041 hypothetical protein from Streptomyces coelicolor (87 aa). Also shows some similarity to Rv0709|MTCY210.28|rpmC from Mycobacterium tuberculosis (77 aa), FASTA score: (28.8% identity in 73 aa overlap). | Anti-anti-sigma factor RsfB (anti-sigma factor antagonist) (regulator of sigma F B); Positive regulator of sigma-F (SigF) activity. Binds to anti- sigma-F factor RsbW (UsfX) preventing its binding to SigF, thus activating transcription. | 0.450 |
Rv1264 | Rv1265 | Rv1264 | Rv1265 | Adenylyl cyclase (ATP pyrophosphate-lyase) (adenylate cyclase); Catalyzes the formation of the second messenger cAMP; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. | Unknown protein; Rv1265, (MTCY50.17c), len: 226 aa. Unknown protein (see citation below). | 0.650 |
Rv1264 | cmr | Rv1264 | Rv1675c | Adenylyl cyclase (ATP pyrophosphate-lyase) (adenylate cyclase); Catalyzes the formation of the second messenger cAMP; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. | Probable transcriptional regulatory protein Cmr; Positively regulates the expression of at least groEL2. Cyclic AMP does not affect transcription in vitro. | 0.543 |
Rv1264 | crp | Rv1264 | Rv3676 | Adenylyl cyclase (ATP pyrophosphate-lyase) (adenylate cyclase); Catalyzes the formation of the second messenger cAMP; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. | Transcriptional regulatory protein Crp (Crp/Fnr-family); Global transcriptional regulator that complexes with cAMP and binds to specific DNA promoter sites, causing DNA-bending, to regulate transcription. cAMP improves binding to specific DNA sequences, probably by altering protein conformation. The CRP regulon is predicted to contain about 115 genes. Some genes are activated by CRP (rpfA, whiB1) while others are repressed (fadD10). There are 2 CRP-binding sites in the promoter of whiB1, at low concentrations of CRP with or without cAMP transcription of whiB1 is enhanced via site CRP1, [...] | 0.696 |
Rv1265 | PE_PGRS6 | Rv1265 | Rv0532 | Unknown protein; Rv1265, (MTCY50.17c), len: 226 aa. Unknown protein (see citation below). | PE-PGRS family protein PE_PGRS6; Rv0532, (MTCY25D10.11), len: 594 aa. PE_PGRS6,Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citation below),similar to others e.g. Y0DP_MYCTU|Q50615 from Mycobacterium tuberculosis (498 aa), FASTA scores: opt: 1703, E(): 0,(58.2% identity in 536 aa overlap). | 0.511 |
Rv1265 | Rv0898c | Rv1265 | Rv0898c | Unknown protein; Rv1265, (MTCY50.17c), len: 226 aa. Unknown protein (see citation below). | Rv0898c, (MTCY31.26c), len: 87 aa. Conserved hypothetical protein, highly similar to CAC01589.1|AL391041 hypothetical protein from Streptomyces coelicolor (87 aa). Also shows some similarity to Rv0709|MTCY210.28|rpmC from Mycobacterium tuberculosis (77 aa), FASTA score: (28.8% identity in 73 aa overlap). | 0.468 |
Rv1265 | Rv1264 | Rv1265 | Rv1264 | Unknown protein; Rv1265, (MTCY50.17c), len: 226 aa. Unknown protein (see citation below). | Adenylyl cyclase (ATP pyrophosphate-lyase) (adenylate cyclase); Catalyzes the formation of the second messenger cAMP; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. | 0.650 |
Rv1265 | Rv1362c | Rv1265 | Rv1362c | Unknown protein; Rv1265, (MTCY50.17c), len: 226 aa. Unknown protein (see citation below). | Possible membrane protein; Rv1362c, (MTCY02B10.26c), len: 220 aa. Possible membrane protein, similar to Mycobacterium tuberculosis hypothetical proteins e.g. Rv1362c|MTCY02B10.27c (25.9% identity in 216 aa overlap), Rv0177, Rv1973, Rv1972, etc. | 0.473 |
Rv1265 | Rv2971 | Rv1265 | Rv2971 | Unknown protein; Rv1265, (MTCY50.17c), len: 226 aa. Unknown protein (see citation below). | Rv2971, (MTCY349.16c), len: 282 aa. Probable oxidoreductase, possibly aldo/keto reductase, equivalent to O69462 putative oxidoreductase from Mycobacterium leprae (282 aa), FASTA scores: opt: 1495, E(): 4.9e-93, (82.35% identity in 272 aa overlap). Also similar to others e.g. Q9KYM9|SC9H11.10C oxidoreductase from Streptomyces coelicolor (276 aa), FASTA scores: opt: 849, E(): 1.2e-49,(51.7% identity in 267 aa overlap); Q9ZBW7|SC4B5.01C putative oxidoreductase from Streptomyces coelicolor (277 aa), FASTA scores: opt: 847, E(): 1.7e-49, (49.1% identity in 271 aa overlap); Q46857|YQHE_ECOLI [...] | 0.660 |
Rv1265 | cmr | Rv1265 | Rv1675c | Unknown protein; Rv1265, (MTCY50.17c), len: 226 aa. Unknown protein (see citation below). | Probable transcriptional regulatory protein Cmr; Positively regulates the expression of at least groEL2. Cyclic AMP does not affect transcription in vitro. | 0.807 |
Rv1265 | crp | Rv1265 | Rv3676 | Unknown protein; Rv1265, (MTCY50.17c), len: 226 aa. Unknown protein (see citation below). | Transcriptional regulatory protein Crp (Crp/Fnr-family); Global transcriptional regulator that complexes with cAMP and binds to specific DNA promoter sites, causing DNA-bending, to regulate transcription. cAMP improves binding to specific DNA sequences, probably by altering protein conformation. The CRP regulon is predicted to contain about 115 genes. Some genes are activated by CRP (rpfA, whiB1) while others are repressed (fadD10). There are 2 CRP-binding sites in the promoter of whiB1, at low concentrations of CRP with or without cAMP transcription of whiB1 is enhanced via site CRP1, [...] | 0.652 |
Rv1265 | mdh | Rv1265 | Rv1240 | Unknown protein; Rv1265, (MTCY50.17c), len: 226 aa. Unknown protein (see citation below). | Probable malate dehydrogenase Mdh; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. | 0.651 |
Rv1265 | rsfB | Rv1265 | Rv3687c | Unknown protein; Rv1265, (MTCY50.17c), len: 226 aa. Unknown protein (see citation below). | Anti-anti-sigma factor RsfB (anti-sigma factor antagonist) (regulator of sigma F B); Positive regulator of sigma-F (SigF) activity. Binds to anti- sigma-F factor RsbW (UsfX) preventing its binding to SigF, thus activating transcription. | 0.479 |
Rv1265 | tuf | Rv1265 | Rv0685 | Unknown protein; Rv1265, (MTCY50.17c), len: 226 aa. Unknown protein (see citation below). | Probable iron-regulated elongation factor TU Tuf (EF-TU); This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. | 0.477 |
Rv1362c | Rv1265 | Rv1362c | Rv1265 | Possible membrane protein; Rv1362c, (MTCY02B10.26c), len: 220 aa. Possible membrane protein, similar to Mycobacterium tuberculosis hypothetical proteins e.g. Rv1362c|MTCY02B10.27c (25.9% identity in 216 aa overlap), Rv0177, Rv1973, Rv1972, etc. | Unknown protein; Rv1265, (MTCY50.17c), len: 226 aa. Unknown protein (see citation below). | 0.473 |
Rv1362c | mdh | Rv1362c | Rv1240 | Possible membrane protein; Rv1362c, (MTCY02B10.26c), len: 220 aa. Possible membrane protein, similar to Mycobacterium tuberculosis hypothetical proteins e.g. Rv1362c|MTCY02B10.27c (25.9% identity in 216 aa overlap), Rv0177, Rv1973, Rv1972, etc. | Probable malate dehydrogenase Mdh; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. | 0.434 |