Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of proteins in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Rv1318c | alkA | Rv1318c | Rv1317c | Possible adenylate cyclase (ATP pyrophosphate-lyase) (adenylyl cyclase); Rv1318c, (MTCY130.03c), len: 541 aa. Possible adenylate cyclase. Some similarity at the c-terminus to CYAA_RHIME|P19485 adenylate cyclase from Rhizobium meliloti (193 aa), FASTA scores, opt: 270, E(): 2.5e-11, (28.8% identity in 184 aa overlap); similar to other mycbacterium tuberculosis putative adenylate cyclases e.g. Rv1319c|MTCY130.04c (535 aa), FASTA scores: opt: 2505, E(): 0, (71.0% identity in 534 aa overlap), also similar to Rv1320c|MTCY130.05c (567 aa), FASTA scores, opt: 2423, E(): 0, (68.7% identity in [...] | Probable bifunctional transcriptional activator/DNA repair enzyme AlkA; Is involved in the adaptive response to alkylation damage in DNA caused by alkylating agents. Repairs the Sp diastereomer of DNA methylphosphotriester lesions by a direct and irreversible transfer of the methyl group to one of its own cysteine residues. Also catalyzes the hydrolysis of the deoxyribose N-glycosidic bond to excise 3- methyladenine, 3-methylguanine, 7-methylguanine, O2-methylthymine, and O2-methylcytosine from the damaged DNA polymer formed by alkylation lesions (By similarity); In the C-terminal sect [...] | 0.785 |
| Rv1318c | ogt | Rv1318c | Rv1316c | Possible adenylate cyclase (ATP pyrophosphate-lyase) (adenylyl cyclase); Rv1318c, (MTCY130.03c), len: 541 aa. Possible adenylate cyclase. Some similarity at the c-terminus to CYAA_RHIME|P19485 adenylate cyclase from Rhizobium meliloti (193 aa), FASTA scores, opt: 270, E(): 2.5e-11, (28.8% identity in 184 aa overlap); similar to other mycbacterium tuberculosis putative adenylate cyclases e.g. Rv1319c|MTCY130.04c (535 aa), FASTA scores: opt: 2505, E(): 0, (71.0% identity in 534 aa overlap), also similar to Rv1320c|MTCY130.05c (567 aa), FASTA scores, opt: 2423, E(): 0, (68.7% identity in [...] | Methylated-DNA--protein-cysteine methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. | 0.785 |
| alkA | Rv1318c | Rv1317c | Rv1318c | Probable bifunctional transcriptional activator/DNA repair enzyme AlkA; Is involved in the adaptive response to alkylation damage in DNA caused by alkylating agents. Repairs the Sp diastereomer of DNA methylphosphotriester lesions by a direct and irreversible transfer of the methyl group to one of its own cysteine residues. Also catalyzes the hydrolysis of the deoxyribose N-glycosidic bond to excise 3- methyladenine, 3-methylguanine, 7-methylguanine, O2-methylthymine, and O2-methylcytosine from the damaged DNA polymer formed by alkylation lesions (By similarity); In the C-terminal sect [...] | Possible adenylate cyclase (ATP pyrophosphate-lyase) (adenylyl cyclase); Rv1318c, (MTCY130.03c), len: 541 aa. Possible adenylate cyclase. Some similarity at the c-terminus to CYAA_RHIME|P19485 adenylate cyclase from Rhizobium meliloti (193 aa), FASTA scores, opt: 270, E(): 2.5e-11, (28.8% identity in 184 aa overlap); similar to other mycbacterium tuberculosis putative adenylate cyclases e.g. Rv1319c|MTCY130.04c (535 aa), FASTA scores: opt: 2505, E(): 0, (71.0% identity in 534 aa overlap), also similar to Rv1320c|MTCY130.05c (567 aa), FASTA scores, opt: 2423, E(): 0, (68.7% identity in [...] | 0.785 |
| alkA | dinP | Rv1317c | Rv3056 | Probable bifunctional transcriptional activator/DNA repair enzyme AlkA; Is involved in the adaptive response to alkylation damage in DNA caused by alkylating agents. Repairs the Sp diastereomer of DNA methylphosphotriester lesions by a direct and irreversible transfer of the methyl group to one of its own cysteine residues. Also catalyzes the hydrolysis of the deoxyribose N-glycosidic bond to excise 3- methyladenine, 3-methylguanine, 7-methylguanine, O2-methylthymine, and O2-methylcytosine from the damaged DNA polymer formed by alkylation lesions (By similarity); In the C-terminal sect [...] | DNA polymerase IV 2; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII (By similarity). | 0.810 |
| alkA | dinX | Rv1317c | Rv1537 | Probable bifunctional transcriptional activator/DNA repair enzyme AlkA; Is involved in the adaptive response to alkylation damage in DNA caused by alkylating agents. Repairs the Sp diastereomer of DNA methylphosphotriester lesions by a direct and irreversible transfer of the methyl group to one of its own cysteine residues. Also catalyzes the hydrolysis of the deoxyribose N-glycosidic bond to excise 3- methyladenine, 3-methylguanine, 7-methylguanine, O2-methylthymine, and O2-methylcytosine from the damaged DNA polymer formed by alkylation lesions (By similarity); In the C-terminal sect [...] | Probable DNA polymerase IV DinX (pol IV 1) (DNA nucleotidyltransferase (DNA-directed)); Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII (By similarity). | 0.917 |
| alkA | dnaQ | Rv1317c | Rv3711c | Probable bifunctional transcriptional activator/DNA repair enzyme AlkA; Is involved in the adaptive response to alkylation damage in DNA caused by alkylating agents. Repairs the Sp diastereomer of DNA methylphosphotriester lesions by a direct and irreversible transfer of the methyl group to one of its own cysteine residues. Also catalyzes the hydrolysis of the deoxyribose N-glycosidic bond to excise 3- methyladenine, 3-methylguanine, 7-methylguanine, O2-methylthymine, and O2-methylcytosine from the damaged DNA polymer formed by alkylation lesions (By similarity); In the C-terminal sect [...] | Rv3711c, (MTV025.059c), len: 329 aa. Probable dnaQ,DNA polymerase III, epsilon subunit, similar to many e.g. Q9RJ41|SCI8.12 from Streptomyces coelicolor (328 aa), FASTA scores: opt: 509, E(): 4.2e-25, (41.6% identity in 315 aa overlap); Q9JYS6|NMB1451 from Neisseria meningitidis (serogroup B) (and Q9JTR5|MA1665 from serogroup A) (470 aa), FASTA scores: opt: 247, E(): 2.6e-08, (33.15% identity in 172 aa overlap); O83649|DP3E_TREPA|DNAQ|TP0643 from Treponema pallidum (215 aa), FASTA scores: opt: 240, E(): 3.7e-08, (29.65% identity in 162 aa overlap); P03007|DP3E_ECOLI|MUTD|B0215 from Esc [...] | 0.750 |
| alkA | mutY | Rv1317c | Rv3589 | Probable bifunctional transcriptional activator/DNA repair enzyme AlkA; Is involved in the adaptive response to alkylation damage in DNA caused by alkylating agents. Repairs the Sp diastereomer of DNA methylphosphotriester lesions by a direct and irreversible transfer of the methyl group to one of its own cysteine residues. Also catalyzes the hydrolysis of the deoxyribose N-glycosidic bond to excise 3- methyladenine, 3-methylguanine, 7-methylguanine, O2-methylthymine, and O2-methylcytosine from the damaged DNA polymer formed by alkylation lesions (By similarity); In the C-terminal sect [...] | Probable adenine glycosylase MutY; Adenine glycosylase active on G:A and C:A mispairs, as well as processing 7,8-dihydro-8-oxoguanine:A (8-oxoG) mismatches. Minor activity against 8-oxoG:G and 8-oxo:T mismatches is also seen. Bind dsDNA oligonucleotides containing the above mismatches. | 0.783 |
| alkA | ogt | Rv1317c | Rv1316c | Probable bifunctional transcriptional activator/DNA repair enzyme AlkA; Is involved in the adaptive response to alkylation damage in DNA caused by alkylating agents. Repairs the Sp diastereomer of DNA methylphosphotriester lesions by a direct and irreversible transfer of the methyl group to one of its own cysteine residues. Also catalyzes the hydrolysis of the deoxyribose N-glycosidic bond to excise 3- methyladenine, 3-methylguanine, 7-methylguanine, O2-methylthymine, and O2-methylcytosine from the damaged DNA polymer formed by alkylation lesions (By similarity); In the C-terminal sect [...] | Methylated-DNA--protein-cysteine methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. | 0.987 |
| alkA | polA | Rv1317c | Rv1629 | Probable bifunctional transcriptional activator/DNA repair enzyme AlkA; Is involved in the adaptive response to alkylation damage in DNA caused by alkylating agents. Repairs the Sp diastereomer of DNA methylphosphotriester lesions by a direct and irreversible transfer of the methyl group to one of its own cysteine residues. Also catalyzes the hydrolysis of the deoxyribose N-glycosidic bond to excise 3- methyladenine, 3-methylguanine, 7-methylguanine, O2-methylthymine, and O2-methylcytosine from the damaged DNA polymer formed by alkylation lesions (By similarity); In the C-terminal sect [...] | Probable DNA polymerase I PolA; In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.836 |
| alkA | recA | Rv1317c | Rv2737c | Probable bifunctional transcriptional activator/DNA repair enzyme AlkA; Is involved in the adaptive response to alkylation damage in DNA caused by alkylating agents. Repairs the Sp diastereomer of DNA methylphosphotriester lesions by a direct and irreversible transfer of the methyl group to one of its own cysteine residues. Also catalyzes the hydrolysis of the deoxyribose N-glycosidic bond to excise 3- methyladenine, 3-methylguanine, 7-methylguanine, O2-methylthymine, and O2-methylcytosine from the damaged DNA polymer formed by alkylation lesions (By similarity); In the C-terminal sect [...] | RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage. | 0.860 |
| alkA | uvrA | Rv1317c | Rv1638 | Probable bifunctional transcriptional activator/DNA repair enzyme AlkA; Is involved in the adaptive response to alkylation damage in DNA caused by alkylating agents. Repairs the Sp diastereomer of DNA methylphosphotriester lesions by a direct and irreversible transfer of the methyl group to one of its own cysteine residues. Also catalyzes the hydrolysis of the deoxyribose N-glycosidic bond to excise 3- methyladenine, 3-methylguanine, 7-methylguanine, O2-methylthymine, and O2-methylcytosine from the damaged DNA polymer formed by alkylation lesions (By similarity); In the C-terminal sect [...] | Probable excinuclease ABC (subunit A-DNA-binding ATPase) UvrA; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. Alone it slightly inhibits RecA-mediated DNA strand exchange, in concert with UvrD1 greatly inhibits RecA-mediated DNA strand exchange. Belongs to the ABC transporter superfamily. UvrA family. | 0.754 |
| alkA | xthA | Rv1317c | Rv0427c | Probable bifunctional transcriptional activator/DNA repair enzyme AlkA; Is involved in the adaptive response to alkylation damage in DNA caused by alkylating agents. Repairs the Sp diastereomer of DNA methylphosphotriester lesions by a direct and irreversible transfer of the methyl group to one of its own cysteine residues. Also catalyzes the hydrolysis of the deoxyribose N-glycosidic bond to excise 3- methyladenine, 3-methylguanine, 7-methylguanine, O2-methylthymine, and O2-methylcytosine from the damaged DNA polymer formed by alkylation lesions (By similarity); In the C-terminal sect [...] | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI); Rv0427c, (MTCY22G10.24c), len: 291 aa. Probable xthA (alternate gene name: xth), exodeoxyribonuclease III protein (see citation below), similar to others e.g. EX3_ECOLI|P09030 exodeoxyribonuclease III from Escherichia Coli strain K12 (268 aa), FASTA scores: opt: 360, E(): 1.2e-17, (29.3% identity in 270 aa overlap); etc. Belongs to the AP/EXOA family of DNA repair enzymes. | 0.894 |
| dinP | alkA | Rv3056 | Rv1317c | DNA polymerase IV 2; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII (By similarity). | Probable bifunctional transcriptional activator/DNA repair enzyme AlkA; Is involved in the adaptive response to alkylation damage in DNA caused by alkylating agents. Repairs the Sp diastereomer of DNA methylphosphotriester lesions by a direct and irreversible transfer of the methyl group to one of its own cysteine residues. Also catalyzes the hydrolysis of the deoxyribose N-glycosidic bond to excise 3- methyladenine, 3-methylguanine, 7-methylguanine, O2-methylthymine, and O2-methylcytosine from the damaged DNA polymer formed by alkylation lesions (By similarity); In the C-terminal sect [...] | 0.810 |
| dinP | dinX | Rv3056 | Rv1537 | DNA polymerase IV 2; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII (By similarity). | Probable DNA polymerase IV DinX (pol IV 1) (DNA nucleotidyltransferase (DNA-directed)); Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII (By similarity). | 0.433 |
| dinP | dnaQ | Rv3056 | Rv3711c | DNA polymerase IV 2; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII (By similarity). | Rv3711c, (MTV025.059c), len: 329 aa. Probable dnaQ,DNA polymerase III, epsilon subunit, similar to many e.g. Q9RJ41|SCI8.12 from Streptomyces coelicolor (328 aa), FASTA scores: opt: 509, E(): 4.2e-25, (41.6% identity in 315 aa overlap); Q9JYS6|NMB1451 from Neisseria meningitidis (serogroup B) (and Q9JTR5|MA1665 from serogroup A) (470 aa), FASTA scores: opt: 247, E(): 2.6e-08, (33.15% identity in 172 aa overlap); O83649|DP3E_TREPA|DNAQ|TP0643 from Treponema pallidum (215 aa), FASTA scores: opt: 240, E(): 3.7e-08, (29.65% identity in 162 aa overlap); P03007|DP3E_ECOLI|MUTD|B0215 from Esc [...] | 0.802 |
| dinP | mutY | Rv3056 | Rv3589 | DNA polymerase IV 2; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII (By similarity). | Probable adenine glycosylase MutY; Adenine glycosylase active on G:A and C:A mispairs, as well as processing 7,8-dihydro-8-oxoguanine:A (8-oxoG) mismatches. Minor activity against 8-oxoG:G and 8-oxo:T mismatches is also seen. Bind dsDNA oligonucleotides containing the above mismatches. | 0.586 |
| dinP | polA | Rv3056 | Rv1629 | DNA polymerase IV 2; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII (By similarity). | Probable DNA polymerase I PolA; In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.815 |
| dinP | recA | Rv3056 | Rv2737c | DNA polymerase IV 2; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII (By similarity). | RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage. | 0.897 |
| dinP | uvrA | Rv3056 | Rv1638 | DNA polymerase IV 2; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII (By similarity). | Probable excinuclease ABC (subunit A-DNA-binding ATPase) UvrA; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. Alone it slightly inhibits RecA-mediated DNA strand exchange, in concert with UvrD1 greatly inhibits RecA-mediated DNA strand exchange. Belongs to the ABC transporter superfamily. UvrA family. | 0.516 |
| dinX | alkA | Rv1537 | Rv1317c | Probable DNA polymerase IV DinX (pol IV 1) (DNA nucleotidyltransferase (DNA-directed)); Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII (By similarity). | Probable bifunctional transcriptional activator/DNA repair enzyme AlkA; Is involved in the adaptive response to alkylation damage in DNA caused by alkylating agents. Repairs the Sp diastereomer of DNA methylphosphotriester lesions by a direct and irreversible transfer of the methyl group to one of its own cysteine residues. Also catalyzes the hydrolysis of the deoxyribose N-glycosidic bond to excise 3- methyladenine, 3-methylguanine, 7-methylguanine, O2-methylthymine, and O2-methylcytosine from the damaged DNA polymer formed by alkylation lesions (By similarity); In the C-terminal sect [...] | 0.917 |
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