| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| PE_PGRS26 | PE_PGRS62 | Rv1441c | Rv3812 | PE-PGRS family protein PE_PGRS26; Rv1441c, (MTCY493.13), len: 491 aa. PE_PGRS26,Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see Brennan & Delogu 2002),similar to Y0DP_MYCTU|Q50615 hypothetical glycine-rich 40.8 kDa protein (498 aa), fasta scores: opt: 1625, E(): 0,(55.2% identity in 518 aa overlap). | PE-PGRS family protein PE_PGRS62; Rv3812, (MTV026.17, MTCY409.18c), len: 504 aa. PE_PGRS62, Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citations below), similar to many e.g. P96828|Rv0151c|MTCI5.25c (588 aa), FASTA scores: opt: 389, E(): 6.2e-14, (29.2% identity in 473 aa overlap); MTCY7H7B_27; MTCY493_24; MTCY441_4; MTCY39_36; MTCY1A11_4; MTCY359_33; MTCY130_10; MTCY98_9; etc. The transcription of this CDS seems to be activated in macrophages (see Ramakrishnan et al., 2000). | 0.457 |
| PE_PGRS26 | PPE18 | Rv1441c | Rv1196 | PE-PGRS family protein PE_PGRS26; Rv1441c, (MTCY493.13), len: 491 aa. PE_PGRS26,Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see Brennan & Delogu 2002),similar to Y0DP_MYCTU|Q50615 hypothetical glycine-rich 40.8 kDa protein (498 aa), fasta scores: opt: 1625, E(): 0,(55.2% identity in 518 aa overlap). | PPE family protein PPE18; Could be a crucial virulence factor for intracellular survival of M.tuberculosis. Favors development of Th2-type response, and downregulates the proinflammatory and Th1-type response. Specifically interacts with the human Toll-like receptor 2 (TLR2), leading to an early and sustained activation of p38 MAPK, which induces IL-10 production and activates Th2-type immune response. Also inhibits proinflammatory cytokines IL-12p40 and TNF-alpha production. Acts by upregulating the expression as well as tyrosine phosphorylation of suppressor of cytokine signaling 3 ( [...] | 0.506 |
| PE_PGRS26 | bisC | Rv1441c | Rv1442 | PE-PGRS family protein PE_PGRS26; Rv1441c, (MTCY493.13), len: 491 aa. PE_PGRS26,Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see Brennan & Delogu 2002),similar to Y0DP_MYCTU|Q50615 hypothetical glycine-rich 40.8 kDa protein (498 aa), fasta scores: opt: 1625, E(): 0,(55.2% identity in 518 aa overlap). | Rv1442, (MTCY493.12c), len: 766 aa. Probable bisC,Biotin sulfoxide reductase, similar to BISC_ECOLI|P20099 biotin sulfoxide reductase from Escherichia coli (739 aa),FASTA scores: opt: 1271, E():0, (40.2% identity in 744 aa overlap); Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. | 0.571 |
| PE_PGRS62 | PE_PGRS26 | Rv3812 | Rv1441c | PE-PGRS family protein PE_PGRS62; Rv3812, (MTV026.17, MTCY409.18c), len: 504 aa. PE_PGRS62, Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citations below), similar to many e.g. P96828|Rv0151c|MTCI5.25c (588 aa), FASTA scores: opt: 389, E(): 6.2e-14, (29.2% identity in 473 aa overlap); MTCY7H7B_27; MTCY493_24; MTCY441_4; MTCY39_36; MTCY1A11_4; MTCY359_33; MTCY130_10; MTCY98_9; etc. The transcription of this CDS seems to be activated in macrophages (see Ramakrishnan et al., 2000). | PE-PGRS family protein PE_PGRS26; Rv1441c, (MTCY493.13), len: 491 aa. PE_PGRS26,Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see Brennan & Delogu 2002),similar to Y0DP_MYCTU|Q50615 hypothetical glycine-rich 40.8 kDa protein (498 aa), fasta scores: opt: 1625, E(): 0,(55.2% identity in 518 aa overlap). | 0.457 |
| PPE18 | PE_PGRS26 | Rv1196 | Rv1441c | PPE family protein PPE18; Could be a crucial virulence factor for intracellular survival of M.tuberculosis. Favors development of Th2-type response, and downregulates the proinflammatory and Th1-type response. Specifically interacts with the human Toll-like receptor 2 (TLR2), leading to an early and sustained activation of p38 MAPK, which induces IL-10 production and activates Th2-type immune response. Also inhibits proinflammatory cytokines IL-12p40 and TNF-alpha production. Acts by upregulating the expression as well as tyrosine phosphorylation of suppressor of cytokine signaling 3 ( [...] | PE-PGRS family protein PE_PGRS26; Rv1441c, (MTCY493.13), len: 491 aa. PE_PGRS26,Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see Brennan & Delogu 2002),similar to Y0DP_MYCTU|Q50615 hypothetical glycine-rich 40.8 kDa protein (498 aa), fasta scores: opt: 1625, E(): 0,(55.2% identity in 518 aa overlap). | 0.506 |
| bisC | PE_PGRS26 | Rv1442 | Rv1441c | Rv1442, (MTCY493.12c), len: 766 aa. Probable bisC,Biotin sulfoxide reductase, similar to BISC_ECOLI|P20099 biotin sulfoxide reductase from Escherichia coli (739 aa),FASTA scores: opt: 1271, E():0, (40.2% identity in 744 aa overlap); Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. | PE-PGRS family protein PE_PGRS26; Rv1441c, (MTCY493.13), len: 491 aa. PE_PGRS26,Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see Brennan & Delogu 2002),similar to Y0DP_MYCTU|Q50615 hypothetical glycine-rich 40.8 kDa protein (498 aa), fasta scores: opt: 1625, E(): 0,(55.2% identity in 518 aa overlap). | 0.571 |
