node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rv1444c | devB | Rv1444c | Rv1445c | Unknown protein; Rv1444c, (MTCY493.10), len: 136 aa. Unknown protein. | Probable 6-phosphogluconolactonase DevB (6PGL); Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. | 0.871 |
Rv1444c | opcA | Rv1444c | Rv1446c | Unknown protein; Rv1444c, (MTCY493.10), len: 136 aa. Unknown protein. | Rv1446c, (MTCY493.08), len: 303 aa. Putative opcA,OxPP cycle protein. Highly similar to S72774 B1496_F1_30 protein from Mycobacterium leprae (265 aa), FASTA scores: opt: 1056, E(): 0, (70.3% identity in 239 aa overlap). Also similar to OPCA_NOSS2|P48971 putative oxppcycle protein opca from Nostoc punctiforme (465 aa), fasta scores: opt: 177, E(): 7.3e-05, (23.4% identity in 321 aa overlap). Aids in G6PD activity. | 0.866 |
Rv1444c | tal | Rv1444c | Rv1448c | Unknown protein; Rv1444c, (MTCY493.10), len: 136 aa. Unknown protein. | Probable transaldolase Tal; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. | 0.803 |
Rv1444c | tkt | Rv1444c | Rv1449c | Unknown protein; Rv1444c, (MTCY493.10), len: 136 aa. Unknown protein. | Transketolase Tkt (TK); Catalyzes the reversible transfer of a two-carbon ketol group from sedoheptulose-7-phosphate to glyceraldehyde-3-phosphate, producing xylulose-5-phosphate and ribose-5-phosphate. Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. Belongs to the transketolase family. | 0.790 |
Rv1444c | zwf2 | Rv1444c | Rv1447c | Unknown protein; Rv1444c, (MTCY493.10), len: 136 aa. Unknown protein. | Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD); Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. | 0.801 |
devB | Rv1444c | Rv1445c | Rv1444c | Probable 6-phosphogluconolactonase DevB (6PGL); Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. | Unknown protein; Rv1444c, (MTCY493.10), len: 136 aa. Unknown protein. | 0.871 |
devB | gap | Rv1445c | Rv1436 | Probable 6-phosphogluconolactonase DevB (6PGL); Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. | Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH); Catalyzes the oxidative phosphorylation of glyceraldehyde 3- phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG; Belongs to the glyceraldehyde-3-ph [...] | 0.808 |
devB | gnd1 | Rv1445c | Rv1844c | Probable 6-phosphogluconolactonase DevB (6PGL); Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. | Probable 6-phosphogluconate dehydrogenase Gnd1; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. | 0.958 |
devB | gnd2 | Rv1445c | Rv1122 | Probable 6-phosphogluconolactonase DevB (6PGL); Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. | Rv1122, (MTCY22G8.11), len: 340 aa. Probable gnd2,6-phosphogluconate dehydrogenase, decarboxylating, highly similar to Q53917 6-phosphogluconate dehydrogenase from Streptomyces coelicolor (291 aa), fasta scores: opt: 431,E(): 2.2e-20, (44.5% identity in 335 aa overlap). Also similar to Rv1844c|MTCY359.29|gnd1 probable 6-phosphogluconate dehydrogenase from Mycobacterium tuberculosis (485 aa), FASTA score: (33.0% identity in 351 aa overlap). Note that Rv1844c|MTCY359.29|gnd1 is most similar to gnd's from Gram negative organisms, while gnd2 is most similar to gnd's from Gram positive orga [...] | 0.964 |
devB | nagA | Rv1445c | Rv3332 | Probable 6-phosphogluconolactonase DevB (6PGL); Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. | Rv3332, (MTV016.32), len: 383 aa. Probable nagA,N-acetylglucosamine-6-phosphate deacetylase, similar to many e.g. Q9KXV7|SCD95A.17c putative deacetylase from Streptomyces coelicolor (381 aa), FASTA scores: opt: 1090,E(): 1.6e-55, (47.8% identity in 385 aa overlap); Q9PDB4|XF1465 N-acetylglucosamine-6-phosphate deacetylase from Xylella fastidiosa (386 aa), FASTA scores: opt: 667,E(): 3.5e-31, (38.3% identity in 394 aa overlap); Q9AAZ9|CC0443 N-acetylglucosamine-6-phosphate deacetylase from Caulobacter crescentus (378 aa), FASTA scores: opt: 661, E(): 7.5e-31, (38.9% identity in 383 aa o [...] | 0.847 |
devB | opcA | Rv1445c | Rv1446c | Probable 6-phosphogluconolactonase DevB (6PGL); Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. | Rv1446c, (MTCY493.08), len: 303 aa. Putative opcA,OxPP cycle protein. Highly similar to S72774 B1496_F1_30 protein from Mycobacterium leprae (265 aa), FASTA scores: opt: 1056, E(): 0, (70.3% identity in 239 aa overlap). Also similar to OPCA_NOSS2|P48971 putative oxppcycle protein opca from Nostoc punctiforme (465 aa), fasta scores: opt: 177, E(): 7.3e-05, (23.4% identity in 321 aa overlap). Aids in G6PD activity. | 0.996 |
devB | tal | Rv1445c | Rv1448c | Probable 6-phosphogluconolactonase DevB (6PGL); Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. | Probable transaldolase Tal; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. | 0.933 |
devB | tkt | Rv1445c | Rv1449c | Probable 6-phosphogluconolactonase DevB (6PGL); Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. | Transketolase Tkt (TK); Catalyzes the reversible transfer of a two-carbon ketol group from sedoheptulose-7-phosphate to glyceraldehyde-3-phosphate, producing xylulose-5-phosphate and ribose-5-phosphate. Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. Belongs to the transketolase family. | 0.912 |
devB | zwf1 | Rv1445c | Rv1121 | Probable 6-phosphogluconolactonase DevB (6PGL); Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. | Probable glucose-6-phosphate 1-dehydrogenase Zwf1 (G6PD); Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. | 0.999 |
devB | zwf2 | Rv1445c | Rv1447c | Probable 6-phosphogluconolactonase DevB (6PGL); Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. | Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD); Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. | 0.999 |
gap | devB | Rv1436 | Rv1445c | Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH); Catalyzes the oxidative phosphorylation of glyceraldehyde 3- phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG; Belongs to the glyceraldehyde-3-ph [...] | Probable 6-phosphogluconolactonase DevB (6PGL); Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. | 0.808 |
gap | gnd1 | Rv1436 | Rv1844c | Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH); Catalyzes the oxidative phosphorylation of glyceraldehyde 3- phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG; Belongs to the glyceraldehyde-3-ph [...] | Probable 6-phosphogluconate dehydrogenase Gnd1; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. | 0.571 |
gap | tal | Rv1436 | Rv1448c | Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH); Catalyzes the oxidative phosphorylation of glyceraldehyde 3- phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG; Belongs to the glyceraldehyde-3-ph [...] | Probable transaldolase Tal; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. | 0.952 |
gap | tkt | Rv1436 | Rv1449c | Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH); Catalyzes the oxidative phosphorylation of glyceraldehyde 3- phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG; Belongs to the glyceraldehyde-3-ph [...] | Transketolase Tkt (TK); Catalyzes the reversible transfer of a two-carbon ketol group from sedoheptulose-7-phosphate to glyceraldehyde-3-phosphate, producing xylulose-5-phosphate and ribose-5-phosphate. Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. Belongs to the transketolase family. | 0.960 |
gap | zwf1 | Rv1436 | Rv1121 | Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH); Catalyzes the oxidative phosphorylation of glyceraldehyde 3- phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG; Belongs to the glyceraldehyde-3-ph [...] | Probable glucose-6-phosphate 1-dehydrogenase Zwf1 (G6PD); Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. | 0.951 |