STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PE_PGRS27PE-PGRS family protein PE_PGRS27; Rv1450c, (MTCY493.04), len: 1329 aa. PE_PGRS27,Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see Brennan and Delogu,2002), similar to Y03A_MYCTU|Q10637 hypothetical glycine-rich 49.6 kDa protein (603 aa), fasta scores: opt: 2112, E(): 0, (56.5% identity in 630 aa overlap). (1329 aa)    
Predicted Functional Partners:
PPE64
Rv3558, (MTCY06G11.05), len: 552 aa. PPE64, Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, similar to many e.g. P71868|Rv3533c|MTCY03C7.23 (582 aa), FASTA scores: opt: 1908, E(): 1.7e-83, (58.5% identity in 583 aa overlap). Predicted to be an outer membrane protein (See Song et al.,2008).
      
 0.870
eccE5
ESX conserved component EccE5. ESX-5 type VII secretion system protein. Probable membrane protein; Part of the ESX-5 specialized secretion system, which is responsible for the secretion of EsxN and a number of PE_PGRS and PPE proteins, including PPE41.
    
 
 0.648
mycP5
Mycosin-5; Rv1796, (MTV049.18), len: 585 aa. Probable mycP5,pro-rich membrane-anchored serine protease (mycosin) (see citations below). Member of family with four other Mycobacterium tuberculosis serine proteases: Rv3886c|O05458|MTCY15F10.26|Z94121 (550 aa), FASTA scores: opt: 1173, E(): 0, (47.9% identity in 578 aa overlap); Rv0291, Rv3883c, and Rv3449. Genes all linked to those of ESAT-6 family. Has possible N-terminal signal peptide and hydrophobic anchor-like stretch at C-terminus. Contains two serine protease, subtilase family active site motifs: a aspartic acid active site motif [...]
  
 
 0.583
zmp1
Rv0198c, (MTV033.06c), len: 663 aa. Probable zmp1,zinc metalloprotease, equivalent to Z95398|MLCL622.12c from Mycobacterium leprae (667 aa), FASTA scores: opt: 3710,E(): 0, (80.8 % identity in 667 aa overlap). Also similar to many other metalloproteases e.g. members of the eukaryotic neprilysin family: P08473|NEP_HUMAN neprilysin (749 aa), FASTA scores: opt: 872, E(): 0, (31.1% identity in 692 aa overlap); Q07744|PEPO_LACLA neutral endopeptidase from Lactococcus lactis (626 aa), FASTA scores: opt: 862,E(): 0, (30.0% identity in 654 aa overlap). Contains PS00142 Neutral zinc metallopept [...]
  
    0.407
eccD5
ESX conserved component EccD5. ESX-5 type VII secretion system protein. Probable membrane protein; Part of the ESX-5 specialized secretion system, which is responsible for the secretion of EsxN and a number of PE_PGRS and PPE proteins, including PPE41.
   
 
 0.407
rpiB
Ribose-5-phosphate isomerase; Catalyzes the interconversion of ribulose-5-P and ribose-5-P. It has not isomerase activity towards D-allose 6-phosphate.
     
 0.405
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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