STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Rv1457cRv1457c, (MTV007.04c), len: 261 aa. Possible unidentified antibiotic-transport integral membrane protein ABC transporter (see citation below), equivalent to Z99125|MLCL536.32 from Mycobacterium leprae (265 aa), FASTA scores: opt: 1415, E(): 0, (83.1% identity in 260 aa overlap). (261 aa)    
Predicted Functional Partners:
Rv1458c
Rv1458c, (MTV007.05c), len: 313 aa. Possible unidentified antibiotic-transport ATP-binding protein ABC transporter (see citation below), equivalent to Z99125|MLCL536.31 from Mycobacterium leprae (315 aa), FASTA scores: opt: 1812, E(): 0, (88.0% identity in 308 aa overlap). Similar to AF027770|AF027770_7 ABC-type transporter in FxbA region in Mycobacterium smegmatis (284 aa), FASTA scores: opt: 1412, E(): 0, (85.1% identity in 248 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature. Belongs to the ATP-binding transport protei [...]
 
 
 0.999
Rv1456c
Rv1456c, (MTV007.03c), len: 310 aa. Possible unidentified antibiotic-transport integral membrane protein ABC transporter (see citation below), equivalent to Z99125|MLCL536.34 from Mycobacterium leprae (311 aa), FASTA scores: opt: 1607, E(): 0, (83.3% identity in 300 aa overlap).
 
 
 0.998
Rv1459c
Possible conserved integral membrane protein; Catalyzes the addition of alpha-(1->6)-mannose residue. Belongs to the MptA/B family.
 
  
 0.977
mptA
Alpha(1->6)mannosyltransferase. Possible conserved integral membrane protein; Involved in the latter stages of the biosynthesis of the alpha-(1->6) mannan core of lipomannan (LM). Catalyzes the addition of alpha-(1->6)-mannose residue.; Belongs to the MptA/B family.
 
  
 0.799
Rv1460
Rv1460, (MTV007.07), len: 268 aa. Probable transcriptional regulatory protein. Equivalent to Z99125|MLCL536.29c hypothetical protein from Mycobacterium leprae (254 aa), FASTA scores: opt: 1273, E(): 0, (79.6% identity in 250 aa overlap). Possible helix-turn-helix motif between aa 68 - 89. Start changed since original submission.
 
    0.779
Rv1463
Rv1463, (MTV007.10), len: 266 aa. Probable conserved ATP-binding protein ABC transporter, equivalent to Z99125|MLCL536.26c putative ABC transporter ATP-binding protein from Mycobacterium leprae (260 aa), FASTA scores: opt: 1444, E(): 0, (86.0% identity in 267 aa overlap). Very similar to U38804|PPU38804_55 ATP-dependent transporter YCF16 from porphyra purpurea chloroplast (251 aa), FASTA scores: opt: 822, E(): 0, (52.4% identity in 248 aa overlap); and similar to others. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Belongs to the ATP-binding transport protein family (ABC tra [...]
  
  
 0.730
csd
Probable cysteine desulfurase Csd; Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.
  
    0.719
Rv1462
Rv1462, (MTV007.09), len: 397 aa. Conserved hypothetical protein. Equivalent to MLCL536.27c|Z99125 hypothetical protein from Mycobacterium leprae (392 aa),FASTA scores: opt: 2059, E(): 0, (80.4% identity in 392 aa overlap). Also similar to nearby Mycobacterium tuberculosis hypothetical protein Rv1461.
  
  
 0.718
Rv1465
Rv1465, (MTV007.12), len: 162 aa. Possible nitrogen fixation related protein. Equivalent to Z99125|MLCL536.24c nitrogen fixation protein NIFU from Mycobacterium leprae (165 aa), FASTA scores: opt: 870, E(): 0, (81.8% identity in 165 aa overlap). Also similar to O32163|Z99120|NIFU_BACSU NifU-like protein from Bacillus subtilis (147 aa), FASTA scores: opt: 354, E(): 4.1e-17,(38.3% identity in 141 aa overlap) and to AL096839|SCC22.02 hypothetical protein from Streptomyces coelicolor (156 aa),FASTA scores: opt: 569, E(): 1.2e-31, (56.3% identity in 158 aa overlap).
  
    0.715
Rv1466
Conserved protein; Rv1466, (MTV007.13), len: 115 aa. Conserved protein. Equivalent to Z99125|MLCL536.23c hypothetical protein from Mycobacterium leprae (115 aa), FASTA scores: opt: 648, E(): 0, (81.7% identity in 115 aa overlap). Similar to ORF's downstream of sigma factors in Streptococcus mutans and Streptococcus pneumoniae e.g. O06451 ORF3 downstream of RpoD (SPDNAGCPO) (109 aa). Alternative TTG start possible at 13757 then avoids overlap with MTV007.12.
  
    0.713
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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