Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
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[Homology]
Score
Rv1576cRv1576c, (MTCY336.28), len: 473 aa. Probable phiRV1 phage protein (capsid subunit) (see citation below). Highly similar to hypothetical Mycobacterium tuberculosis protein Rv2650c|MTCY441.19 phiRV2 phage related protein, FASTA scores: opt: 2782, E(): 0, (89.1% identity in 468 aa overlap). This region is a possible MT-complex-specific genomic island (See Becq et al., 2007). (473 aa)    
Predicted Functional Partners:
Rv1577c
Rv1577c, (MTCY336.27), len: 170 aa. Probable phiRv1 phage protein (prohead protease) (see citation below). Highly similar to hypothetical protein Rv2651c|MTCY441.20c phiRV2 prohead protease, FASTA scores: E(): 0, (89.3% identity in 169 aa overlap). Some similarity to VP4_BPHK7|P49860 putative bacteriophage HK97 prohead protease (gp4) (225 aa), FASTA results: opt: 176, E(): 1.3e-05, (27.3% identity in 165 aa overlap). This region is a possible MT-complex-specific genomic island (See Becq et al., 2007).
 
  
 0.985
Rv2651c
Rv2651c, (MTCY441.20c), len: 177 aa. Possible protease protein, phiRv2 phage protein (prohead protease) (see citation below), showing some similarity with several proteases e.g. Q9A4P4|CC2786 putative protease from Caulobacter crescentus (138 aa), FASTA scores: opt: 206,E(): 2e-06, (36.35% identity in 132 aa overlap); Q9RNH0 putative prohead protease from Rhodobacter capsulatus (Rhodopseudomonas capsulata) (184 aa), FASTA scores: opt: 196, E(): 1.1e-05, (35.05% identity in 137 aa overlap); BAB35014|ECS1591 putative prohead protease from Escherichia coli strain O157:H7 (185 aa), FASTA s [...]
 
  
 0.911
Rv1586c
Probable PhiRv1 integrase; Rv1586c, (MTCY336.18), len: 469 aa. Probable phiRv1 integrase, possibly member of the serine family of recombinases (see citation below), similar to several bacteriophage integrases e.g. Q37839 ORF469 protein from Bacteriophage R4 (469 aa), FASTA scores: opt: 623, E(): 1.6e-29, (31.1% identity in 482 aa overlap); and Bacteriophage TP901-1. This region is a possible MT-complex-specific genomic island (See Becq et al.,2007).
 
  
 0.859
Rv2650c
Rv2650c, (MTCY441.19), len: 479 aa. Possible phiRv2 prophage protein (capsid subunit) (see citation below),highly similar to O06614|Rv1576c|MTCY336.28 probable phiRv1 phage protein from Mycobacterium tuberculosis (473 aa),FASTA scores: opt: 2782, E(): 2.8e-159, (89.1% identity in 468 aa overlap).
  
   
0.841
Rv2263
Rv2263, (MTV022.13), len: 317 aa. Possible oxidoreductase, similar to several oxidoreductases. Similarity suggests alternative GTG start at 10154 but then no rbs. FASTA scores: sptr|Q544 05|Q54405 probably an NADP-dependent oxidoreductase (297 aa) opt: 487, E(): 1.1e-23; (36.1% identity in 299 aa overlap). Also similar to Mycobacterium tuberculosis Rv0068, and Rv0439c; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
      
 0.824
Rv1762c
Unknown protein; Rv1762c, (MTCY28.28c), len: 262 aa. Unknown protein.
      
 0.819
spmT
Probable exported protein; Catalyzes the cleavage of sphingomyelin, a major lipid in eukaryotic cells, into ceramide and phosphocholine, which are then utilized by M.tuberculosis as carbon, nitrogen and phosphorus sources, respectively. Thus, enables M.tuberculosis to utilize sphingomyelin as a source of several essential nutrients for intracellular growth during infection. Furthermore, lyses erythrocytes and constitutes the main hemolytic factor of M.tuberculosis.
  
  
 0.781
Rv1578c
Rv1578c, (MTCY336.26), len: 156 aa. Probable phiRv1 phage protein (terminase) (see citation below), highly similar to Rv2652c|MTCY441.21c phiRV2 phage protein from Mycobacterium tuberculosis, FASTA scores: E(): 4.8e-22,(48.1% identity in 156 aa overlap). Also similar to X65555|ARP3COS_1 hypothetical protein (cos site) -actinophage RP3 (210 aa), FASTA scores: opt: 373, E(): 6.5e-17, (50.0% identity in 114 aa overlap). Contains MIP family signature (PS00221). This region is a possible MT-complex-specific genomic island (See Becq et al.,2007).
 
  
 0.701
PPE8
PPE family protein PPE8; Rv0355c, (MTCY13E10.15c, MTCY13E10.16c,MTCY13E10.17c), len: 3300 aa. PPE8, Member of the Mycobacterium tuberculosis PPE family, similar to others e.g. AL009198|MTV004_5 from Mycobacterium tuberculosis (3716 aa), FASTA scores: opt: 2906, E(): 0, (40.9% identity in 3833 aa overlap); MTV004_3 FASTA scores: (39.0% identity in 3531 aa overlap); etc. Gene contains large number of clustered Major Polymorphic Tandem Repeats (MPTR). Related to MTCY13E10.16c, E(): 0; MTCY13E10.17c, E(): 0; MTCY48.17,E(): 0; MTCY98.0034c, E(): 0; MTCY03C7.23 E(): 0; MTCY98.0031c, E(): 0; [...]
  
     0.700
PPE55
Rv3347c, (MTV004.03c), len: 3157 aa. PPE55, Member of the Mycobacterium tuberculosis PPE family, Gly-, Ala-,Asn-rich protein. Similar to many from Mycobacterium tuberculosis strains H37Rv and CDC1551, e.g. O50379|Rv3350c|MTV004.07c (3716 aa), FASTA scores: opt: 6497, E(): 0, (61.65% identity in 3756 aa overlap); and other upstream ORFs MTV004_5, MTY13E10_15, MTCY28_16,MTCY63_9, MTY13E10_17, MTCY180_1; etc. Predicted possible vaccine candidate (See Zvi et al., 2008).
  
    0.700
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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