node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
eccA5 | eccB5 | Rv1798 | Rv1782 | ESX conserved component EccA5. ESX-5 type VII secretion system protein; Part of the ESX-5 specialized secretion system, which is responsible for the secretion of EsxN and a number of PE_PGRS and PPE proteins, including PPE41. EccA5 exhibits ATPase activity and may provide energy for the export of ESX-5 substrates (By similarity).; Belongs to the CbxX/CfxQ family. | ESX conserved component EccB5. ESX-5 type VII secretion system protein. Probable membrane protein; An ATPase (shown for residues 80-506). Part of the ESX-5 specialized secretion system, which is responsible for the secretion of EsxN and a number of PE_PGRS and PPE proteins, including PPE41.; Belongs to the EccB family. | 0.848 |
eccA5 | eccC2 | Rv1798 | Rv3894c | ESX conserved component EccA5. ESX-5 type VII secretion system protein; Part of the ESX-5 specialized secretion system, which is responsible for the secretion of EsxN and a number of PE_PGRS and PPE proteins, including PPE41. EccA5 exhibits ATPase activity and may provide energy for the export of ESX-5 substrates (By similarity).; Belongs to the CbxX/CfxQ family. | Rv3894c, (MTCY15F10.18), len: 1396 aa. EccC2, esx conserved component, ESX-2 type VII secretion system protein, possible membrane protein (possible transmembrane segments from aa ~37-85), similar to Q9CD30|ML2535 hypothetical protein from Mycobacterium leprae (1329 aa),FASTA scores: opt: 652, E(): 2.2e-30, (27.85% identity in 1425 aa overlap); Q9CDD7|ML0052 hypothetical protein from Mycobacterium leprae (597 aa), FASTA scores: opt: 537, E(): 6.6e-24, (27.5% identity in 585 aa overlap) (similarity only with C-terminal end); Q9Z5I2|ML1543|MLCB596.28 possible SPOIIIE-family membrane prote [...] | 0.502 |
eccA5 | eccC5 | Rv1798 | Rv1783 | ESX conserved component EccA5. ESX-5 type VII secretion system protein; Part of the ESX-5 specialized secretion system, which is responsible for the secretion of EsxN and a number of PE_PGRS and PPE proteins, including PPE41. EccA5 exhibits ATPase activity and may provide energy for the export of ESX-5 substrates (By similarity).; Belongs to the CbxX/CfxQ family. | ESX conserved component EccC5. ESX-5 type VII secretion system protein; Part of the ESX-5 specialized secretion system, which is responsible for the secretion of EsxN and a number of PE_PGRS and PPE proteins, including PPE41. | 0.595 |
eccA5 | eccD5 | Rv1798 | Rv1795 | ESX conserved component EccA5. ESX-5 type VII secretion system protein; Part of the ESX-5 specialized secretion system, which is responsible for the secretion of EsxN and a number of PE_PGRS and PPE proteins, including PPE41. EccA5 exhibits ATPase activity and may provide energy for the export of ESX-5 substrates (By similarity).; Belongs to the CbxX/CfxQ family. | ESX conserved component EccD5. ESX-5 type VII secretion system protein. Probable membrane protein; Part of the ESX-5 specialized secretion system, which is responsible for the secretion of EsxN and a number of PE_PGRS and PPE proteins, including PPE41. | 0.931 |
eccA5 | eccE5 | Rv1798 | Rv1797 | ESX conserved component EccA5. ESX-5 type VII secretion system protein; Part of the ESX-5 specialized secretion system, which is responsible for the secretion of EsxN and a number of PE_PGRS and PPE proteins, including PPE41. EccA5 exhibits ATPase activity and may provide energy for the export of ESX-5 substrates (By similarity).; Belongs to the CbxX/CfxQ family. | ESX conserved component EccE5. ESX-5 type VII secretion system protein. Probable membrane protein; Part of the ESX-5 specialized secretion system, which is responsible for the secretion of EsxN and a number of PE_PGRS and PPE proteins, including PPE41. | 0.951 |
eccA5 | espG5 | Rv1798 | Rv1794 | ESX conserved component EccA5. ESX-5 type VII secretion system protein; Part of the ESX-5 specialized secretion system, which is responsible for the secretion of EsxN and a number of PE_PGRS and PPE proteins, including PPE41. EccA5 exhibits ATPase activity and may provide energy for the export of ESX-5 substrates (By similarity).; Belongs to the CbxX/CfxQ family. | Conserved protein; Specific chaperone for cognate PE/PPE proteins. Plays an important role in preventing aggregation of PE/PPE dimers. Belongs to the EspG family. | 0.727 |
eccA5 | mycP5 | Rv1798 | Rv1796 | ESX conserved component EccA5. ESX-5 type VII secretion system protein; Part of the ESX-5 specialized secretion system, which is responsible for the secretion of EsxN and a number of PE_PGRS and PPE proteins, including PPE41. EccA5 exhibits ATPase activity and may provide energy for the export of ESX-5 substrates (By similarity).; Belongs to the CbxX/CfxQ family. | Mycosin-5; Rv1796, (MTV049.18), len: 585 aa. Probable mycP5,pro-rich membrane-anchored serine protease (mycosin) (see citations below). Member of family with four other Mycobacterium tuberculosis serine proteases: Rv3886c|O05458|MTCY15F10.26|Z94121 (550 aa), FASTA scores: opt: 1173, E(): 0, (47.9% identity in 578 aa overlap); Rv0291, Rv3883c, and Rv3449. Genes all linked to those of ESAT-6 family. Has possible N-terminal signal peptide and hydrophobic anchor-like stretch at C-terminus. Contains two serine protease, subtilase family active site motifs: a aspartic acid active site motif [...] | 0.970 |
eccB3 | eccC2 | Rv0283 | Rv3894c | ESX conserved component EccB3. ESX-3 type VII secretion system protein. Possible membrane protein; An ATPase (By similarity). Part of the ESX-3 specialized secretion system, which is important for iron and zinc uptake or homeostasis.; Belongs to the EccB family. | Rv3894c, (MTCY15F10.18), len: 1396 aa. EccC2, esx conserved component, ESX-2 type VII secretion system protein, possible membrane protein (possible transmembrane segments from aa ~37-85), similar to Q9CD30|ML2535 hypothetical protein from Mycobacterium leprae (1329 aa),FASTA scores: opt: 652, E(): 2.2e-30, (27.85% identity in 1425 aa overlap); Q9CDD7|ML0052 hypothetical protein from Mycobacterium leprae (597 aa), FASTA scores: opt: 537, E(): 6.6e-24, (27.5% identity in 585 aa overlap) (similarity only with C-terminal end); Q9Z5I2|ML1543|MLCB596.28 possible SPOIIIE-family membrane prote [...] | 0.907 |
eccB3 | eccC3 | Rv0283 | Rv0284 | ESX conserved component EccB3. ESX-3 type VII secretion system protein. Possible membrane protein; An ATPase (By similarity). Part of the ESX-3 specialized secretion system, which is important for iron and zinc uptake or homeostasis.; Belongs to the EccB family. | ESX conserved component EccC3. ESX-3 type VII secretion system protein. Possible membrane protein; Part of the ESX-3 specialized secretion system, which is important for iron and zinc uptake or homeostasis. | 0.999 |
eccB3 | eccC4 | Rv0283 | Rv3447c | ESX conserved component EccB3. ESX-3 type VII secretion system protein. Possible membrane protein; An ATPase (By similarity). Part of the ESX-3 specialized secretion system, which is important for iron and zinc uptake or homeostasis.; Belongs to the EccB family. | Rv3447c, (MTCY77.19c), len: 1236 aa. EccC4, esx conserved component, ESX-4 type VII secretion system protein, probable membrane protein, similar to various bacterial proteins e.g. O86653|SC3C3.20c ATP/GTP binding protein from Streptomyces coelicolor (1321 aa), FASTA scores: opt: 1186, E(): 1.9e-60, (42.9% identity in 1312 aa overlap); Q9L0T6|SCD35.15c from Streptomyces coelicolor (1525 aa), FASTA scores: opt: 932, E(): 9.2e-46, (27.2% identity in 1374 aa overlap); Q9CD30|ML2535 hypothetical protein from Mycobacterium leprae (1329 aa), FASTA scores: opt: 910, E(): 1.5e-44, (34.4% identi [...] | 0.931 |
eccB3 | eccC5 | Rv0283 | Rv1783 | ESX conserved component EccB3. ESX-3 type VII secretion system protein. Possible membrane protein; An ATPase (By similarity). Part of the ESX-3 specialized secretion system, which is important for iron and zinc uptake or homeostasis.; Belongs to the EccB family. | ESX conserved component EccC5. ESX-5 type VII secretion system protein; Part of the ESX-5 specialized secretion system, which is responsible for the secretion of EsxN and a number of PE_PGRS and PPE proteins, including PPE41. | 0.933 |
eccB3 | eccD5 | Rv0283 | Rv1795 | ESX conserved component EccB3. ESX-3 type VII secretion system protein. Possible membrane protein; An ATPase (By similarity). Part of the ESX-3 specialized secretion system, which is important for iron and zinc uptake or homeostasis.; Belongs to the EccB family. | ESX conserved component EccD5. ESX-5 type VII secretion system protein. Probable membrane protein; Part of the ESX-5 specialized secretion system, which is responsible for the secretion of EsxN and a number of PE_PGRS and PPE proteins, including PPE41. | 0.958 |
eccB3 | eccE5 | Rv0283 | Rv1797 | ESX conserved component EccB3. ESX-3 type VII secretion system protein. Possible membrane protein; An ATPase (By similarity). Part of the ESX-3 specialized secretion system, which is important for iron and zinc uptake or homeostasis.; Belongs to the EccB family. | ESX conserved component EccE5. ESX-5 type VII secretion system protein. Probable membrane protein; Part of the ESX-5 specialized secretion system, which is responsible for the secretion of EsxN and a number of PE_PGRS and PPE proteins, including PPE41. | 0.549 |
eccB3 | mycP5 | Rv0283 | Rv1796 | ESX conserved component EccB3. ESX-3 type VII secretion system protein. Possible membrane protein; An ATPase (By similarity). Part of the ESX-3 specialized secretion system, which is important for iron and zinc uptake or homeostasis.; Belongs to the EccB family. | Mycosin-5; Rv1796, (MTV049.18), len: 585 aa. Probable mycP5,pro-rich membrane-anchored serine protease (mycosin) (see citations below). Member of family with four other Mycobacterium tuberculosis serine proteases: Rv3886c|O05458|MTCY15F10.26|Z94121 (550 aa), FASTA scores: opt: 1173, E(): 0, (47.9% identity in 578 aa overlap); Rv0291, Rv3883c, and Rv3449. Genes all linked to those of ESAT-6 family. Has possible N-terminal signal peptide and hydrophobic anchor-like stretch at C-terminus. Contains two serine protease, subtilase family active site motifs: a aspartic acid active site motif [...] | 0.652 |
eccB5 | eccA5 | Rv1782 | Rv1798 | ESX conserved component EccB5. ESX-5 type VII secretion system protein. Probable membrane protein; An ATPase (shown for residues 80-506). Part of the ESX-5 specialized secretion system, which is responsible for the secretion of EsxN and a number of PE_PGRS and PPE proteins, including PPE41.; Belongs to the EccB family. | ESX conserved component EccA5. ESX-5 type VII secretion system protein; Part of the ESX-5 specialized secretion system, which is responsible for the secretion of EsxN and a number of PE_PGRS and PPE proteins, including PPE41. EccA5 exhibits ATPase activity and may provide energy for the export of ESX-5 substrates (By similarity).; Belongs to the CbxX/CfxQ family. | 0.848 |
eccB5 | eccC2 | Rv1782 | Rv3894c | ESX conserved component EccB5. ESX-5 type VII secretion system protein. Probable membrane protein; An ATPase (shown for residues 80-506). Part of the ESX-5 specialized secretion system, which is responsible for the secretion of EsxN and a number of PE_PGRS and PPE proteins, including PPE41.; Belongs to the EccB family. | Rv3894c, (MTCY15F10.18), len: 1396 aa. EccC2, esx conserved component, ESX-2 type VII secretion system protein, possible membrane protein (possible transmembrane segments from aa ~37-85), similar to Q9CD30|ML2535 hypothetical protein from Mycobacterium leprae (1329 aa),FASTA scores: opt: 652, E(): 2.2e-30, (27.85% identity in 1425 aa overlap); Q9CDD7|ML0052 hypothetical protein from Mycobacterium leprae (597 aa), FASTA scores: opt: 537, E(): 6.6e-24, (27.5% identity in 585 aa overlap) (similarity only with C-terminal end); Q9Z5I2|ML1543|MLCB596.28 possible SPOIIIE-family membrane prote [...] | 0.994 |
eccB5 | eccC3 | Rv1782 | Rv0284 | ESX conserved component EccB5. ESX-5 type VII secretion system protein. Probable membrane protein; An ATPase (shown for residues 80-506). Part of the ESX-5 specialized secretion system, which is responsible for the secretion of EsxN and a number of PE_PGRS and PPE proteins, including PPE41.; Belongs to the EccB family. | ESX conserved component EccC3. ESX-3 type VII secretion system protein. Possible membrane protein; Part of the ESX-3 specialized secretion system, which is important for iron and zinc uptake or homeostasis. | 0.950 |
eccB5 | eccC4 | Rv1782 | Rv3447c | ESX conserved component EccB5. ESX-5 type VII secretion system protein. Probable membrane protein; An ATPase (shown for residues 80-506). Part of the ESX-5 specialized secretion system, which is responsible for the secretion of EsxN and a number of PE_PGRS and PPE proteins, including PPE41.; Belongs to the EccB family. | Rv3447c, (MTCY77.19c), len: 1236 aa. EccC4, esx conserved component, ESX-4 type VII secretion system protein, probable membrane protein, similar to various bacterial proteins e.g. O86653|SC3C3.20c ATP/GTP binding protein from Streptomyces coelicolor (1321 aa), FASTA scores: opt: 1186, E(): 1.9e-60, (42.9% identity in 1312 aa overlap); Q9L0T6|SCD35.15c from Streptomyces coelicolor (1525 aa), FASTA scores: opt: 932, E(): 9.2e-46, (27.2% identity in 1374 aa overlap); Q9CD30|ML2535 hypothetical protein from Mycobacterium leprae (1329 aa), FASTA scores: opt: 910, E(): 1.5e-44, (34.4% identi [...] | 0.927 |
eccB5 | eccC5 | Rv1782 | Rv1783 | ESX conserved component EccB5. ESX-5 type VII secretion system protein. Probable membrane protein; An ATPase (shown for residues 80-506). Part of the ESX-5 specialized secretion system, which is responsible for the secretion of EsxN and a number of PE_PGRS and PPE proteins, including PPE41.; Belongs to the EccB family. | ESX conserved component EccC5. ESX-5 type VII secretion system protein; Part of the ESX-5 specialized secretion system, which is responsible for the secretion of EsxN and a number of PE_PGRS and PPE proteins, including PPE41. | 0.999 |
eccB5 | eccD5 | Rv1782 | Rv1795 | ESX conserved component EccB5. ESX-5 type VII secretion system protein. Probable membrane protein; An ATPase (shown for residues 80-506). Part of the ESX-5 specialized secretion system, which is responsible for the secretion of EsxN and a number of PE_PGRS and PPE proteins, including PPE41.; Belongs to the EccB family. | ESX conserved component EccD5. ESX-5 type VII secretion system protein. Probable membrane protein; Part of the ESX-5 specialized secretion system, which is responsible for the secretion of EsxN and a number of PE_PGRS and PPE proteins, including PPE41. | 0.999 |