STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Rv1841cRv1841c, (MTCY359.32), len: 345 aa. Conserved hypothetical membrane protein. Some similarity to O07585|YHDP_BACSU hypothetical 49.9 kDa protein from Bacillus subtilis (444 aa), FASTA scores: opt: 620, E(): 0,(31.1% identity in 350 aa overlap). Also similar to other Mycobacterium tuberculosis proteins e.g. Rv1842c, Rv2366c. (345 aa)    
Predicted Functional Partners:
Rv1842c
Rv1842c, (MTCY359.31), len: 455 aa. Conserved hypothetical membrane protein. Similar to Z99109|0O7589 Potential integral membrane protein from Bacillus subtilis (461 aa), FASTA scores: opt: 723, E(): 0, (31.2% identity in 449 aa overlap). Similar to other Mycobacterium tuberculosis putative integral membrane proteins e.g. Rv2366c, Rv1841c.
 
  
0.981
Rv1879
Rv1879, (MTCY180.39c), len: 378 aa. Conserved hypothetical protein, similar to SCC22.14c|AL096839 hypothetical protein from Streptomyces coelicolor (368 aa),FASTA results: opt: 772, E(): 0 (40.3% identity in 372 aa overlap); and to N-terminal half of nodulin/glutamate-ammonia ligase-like protein. Some similarity to N-terminus of AL132958|ATT4D2_11 Arabidopsis thaliana (845 aa), FASTA results: opt: 354, E(): 3.1e-16,(29.2% identity in 383 aa overlap); and to P38094|FLUG_EMENI Flug protein of Emericella nidulans (865 aa), FASTA results: opt: 306, E(): 6.2e-13, (26.5% identity in 415 aa o [...]
  
  
 0.805
guaB1
Probable inosine-5'-monophosphate dehydrogenase GuaB1(imp dehydrogenase) (IMPDH) (IMPD); Has no inosine-5'-monophosphate dehydrogenase activity. Belongs to the IMPDH/GMPR family.
  
  
 0.789
gnd1
Probable 6-phosphogluconate dehydrogenase Gnd1; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
  
    0.733
blaR
Rv1845c, (MTCY359.28), len: 316 aa. Possible blaR,sensor-transducer protein. Conserved hypothetical transmembrane protein. Equivalent to MLCB1788.18|AL008609 Hypothetical protein from Mycobacterium leprae (316 aa),FASTA scores: opt: 1762, E(): 0, (87.6% identity in 314 aa overlap). Similar to proteins in Streptomyces coelicolor e.g. SC10A7.04|AL078618.1.
  
    0.712
blaI
Transcriptional repressor BlaI; Transcription regulator that binds to an inverted DNA repeat with the consensus sequence 5'-TAC[GT]AC-NNNNN-GT[AC]GTA-3' and regulates genes involved in antibiotic transport, detoxification and cell wall function. Also regulates its own transcription. Binds DNA as a dimer; Belongs to the BlaI transcriptional regulatory family.
  
    0.698
Rv2016
Hypothetical protein; Rv2016, (MTV018.03), len: 191 aa. Hypothetical protein.
      
 0.655
vapC45
Conserved protein; Toxic component of a type II toxin-antitoxin (TA) system. An RNase. The cognate antitoxin is VapB45.
   
  
 0.653
glcB
Malate synthase G GlcB; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA.
  
    0.643
glnA3
Rv1878, (MTCY180.40c), len: 450 aa. Probable glnA3,glutamine synthetase class I, similar to many e.g. GLNA_BACCE|P19064 from Bacillus cereus (443 aa), FASTA results: opt: 497, E(): 5.2e-23, (29.0% identity in 331 aa overlap); etc. Also similar to C-terminus of FLUG_EMENI|P38094 flug protein from emericella nidulans (865 aa), FASTA scores: opt: 227, E (): 6.4e-13, (29.9% identity in 394 aa overlap). Note that the downstream ORF MTCY180.39c is similar to the N-terminus. Also similar to three other potential glutamine synthases in M. tuberculosis: Q10378|GLN2_MYCTU|GLNA2|Rv2222c|MT2280|MT [...]
   
  
 0.638
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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