STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
echA13Possible enoyl-CoA hydratase EchA13 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase); Rv1935c, (MTCY09F9.29), len: 318 aa. Possible echA13, enoyl-CoA hydratase, similar to others and various enzymes e.g. CAC48381.1|Y16952 putative enoyl-CoA-isomerase from Amycolatopsis mediterranei (269 aa); AAK18173.1|AF290950_5|AF290950|FadB1x enoyl-CoA hydratase from Pseudomonas putida (257 aa); AAF78820.1|AF042490 4-chlorobenzoyl CoA dehalogenase from Arthrobacter sp. TM1 (276 aa); ECHM_RAT|P14604 enoyl-CoA hydratase mitochondrial precursor from Rattus norvegicus (Rat) (290 aa), FASTA s [...] (318 aa)    
Predicted Functional Partners:
fadE17
Rv1934c, (MTCY09F9.30), len: 409 aa. Probable fadE17, acyl-CoA dehydrogenase, highly similar to ACD_MYCLE|P46703 acyl-CoA dehydrogenase from Mycobacterium leprae (389 aa), FASTA scores: opt: 414, E(): 2.6e-19,(28.3% identity in 407 aa overlap). Also similar to many e.g. NP_249713.1|NC_002516 probable acyl-CoA dehydrogenase from Pseudomonas aeruginosa (381 aa); NP_420614.1|NC_002696 acyl-CoA dehydrogenase family protein from Caulobacter crescentus (355 aa); CAB61610.1|AL133210 putative acyl-CoA dehydrogenase from Streptomyces coelicolor (393 aa); etc. Also similar to others from Mycobac [...]
  
 0.993
fadE18
Rv1933c, (MTCY09F9.31), len: 363 aa. Probable fadE18, acyl-CoA dehydrogenase, similar to many e.g. CAB61609.1|AL133210 putative acyl-CoA dehydrogenase from Streptomyces coelicolor (362 aa); NP_421282.1|NC_002696 acyl-CoA dehydrogenase family protein from Caulobacter crescentus (344 aa); ACDS_RAT|P15651 short-chain specific acyl-CoA dehydrogenase from Rattus norvegicus (Rat) (412 aa), fasta scores: opt: 239, E(): 2.1e-08, (28.4% identity in 331 aa overlap); etc. Also similar to others from Mycobacterium tuberculosis e.g. N-terminus of fadE22 (721 aa); fadE33 (318 aa); N-terminus of fadE [...]
  
 0.934
Rv1936
Possible monooxygenase; Rv1936, (MTCY09F9.28c), len: 369 aa. Possible monooxygenase, similar to LXA2_PHOLU|P23146 alkanal monooxygenase alpha chain (362 aa), FASTA scores: opt: 196,E(): 6.3e-06, (22.3% identity in 373 aa overlap). Also similar to many other Mycobacterium tuberculosis hypothetical oxidoreductases and monooxygenases e.g. Rv0953c, Rv0791c, Rv0132c, etc.
 
  
 0.908
fadE23
Rv3140, (MTCY03A2.18c), len: 401 aa. Probable fadE23, acyl-CoA dehydrogenase (1.3.99.-) (see citation below), equivalent to O32891|MLCB1779.31|FADE23|ML0660 putative acyl-CoA dehydrogenase from Mycobacterium leprae (400 aa), FASTA scores: opt: 2307, E(): 3e-136, (89.5% identity in 401 aa overlap). Also similar to others e.g. Q9HUH1|PA4994 from Pseudomonas aeruginosa (402 aa), FASTA scores: opt: 1558, E(): 1.2e-89, (61.0% identity in 400 aa overlap); O31251 from Acinetobacter sp. ADP1 (401 aa),FASTA scores: opt: 1509, E(): 1.3e-86, (58.2% identity in 402 aa overlap); Q9K6D1|ACDA or BH37 [...]
  
 0.859
fadE19
Possible acyl-CoA dehydrogenase FadE19 (MMGC); Rv2500c, (MTCY07A7.06c), len: 394 aa. Possible fadE19 (alternate gene name: mmgC), acyl-CoA dehydrogenase,similar to many e.g. Q9XCG6|ACDH from Streptomyces coelicolor (386 aa), FASTA scores: opt: 1714, E(): 1.1e-98,(69.45% identity in 383 aa overlap); Q9XCG5|ACDH from Streptomyces avermitilis (386 aa), FASTA scores: opt: 1713,E(): 1.3e-98, (70.0% identity in 383 aa overlap); Q9L7W5|FENK from Bacillus subtilis (370 aa), FASTA scores: opt: 1094, E(): 2.3e-60, (48.4% identity in 372 aa overlap); etc. Contains PS00072 Acyl-CoA dehydrogenases [...]
  
 0.851
fadE1
Rv0131c, (MTCI5.05c), len: 447 aa. Probable fadE1,acyl-CoA dehydrogenase, similar to many e.g. ACDS_HUMAN|P16219 acyl-CoA dehydrogenase short-chain specific precursor (412 aa), FASTA scores: opt: 522, E(): 1.4e-23, (30.1% identity in 425 aa overlap). Also highly similar to MTCI5_28 from Mycobacterium tuberculosis.
  
 0.850
fadE13
Rv0975c, (MTV044.03c), len: 382 aa. Probable fadE13,acyl-CoA dehydrogenase, highly similar to many e.g. T35427 probable acyl-CoA dehydrogenase from Streptomyces coelicolor (382 aa); M74096|HUMACADL_1 Human long chain acyl-CoA dehydrogenase from Homo sapiens (430 aa), FASTA scores: opt: 819, E(): 0, (37.0% identity in 376 aa overlap); etc. Also similar to others from Mycobacterium tuberculosis e.g. fadE20|Z98209|MTCY154_4 (386 aa), FASTA scores: (40.3% identity in 375 aa overlap). Contains PS00073 Acyl-CoA dehydrogenases signature 2. Belongs to the acyl-CoA dehydrogenases family.
  
 0.850
fadE2
Rv0154c, (MTCI5.28c), len: 403 aa. Probable fadE2,acyl-CoA dehydrogenase, similar to many e.g. C-terminal region of O01590 acyl-CoA dehydrogenase (974 aa), FASTA scores: opt: 1150, E(): 0, (50.0% identity in 402 aa overlap); ACDS_MEGEL|Q06319 acyl-CoA dehydrogenase (short-chain) (383 aa), FASTA score: (35.0% identity in 306 aa overlap). Could belong to the acyl-CoA dehydrogenases family.
  
 0.849
fadE4
Rv0231, (MTCY08D5.27), len: 568 aa. Probable fadE4,acyl-CoA dehydrogenase, similar to many e.g. O29752 acyl-CoA dehydrogenase (ACD-3) from Archaeoglobus fulgidus (576 aa), FASTA scores: opt: 1788, E(): 0, (51.0% identity in 577 aa overlap); ACDB_BACSU|P45857 acyl-CoA dehydrogenase from Bacillus subtilis (379 aa), FASTA scores: opt: 232, E(): 2.2e- 08, (21.6% identity in 291 aa overlap).
  
 0.849
fadE7
Acyl-CoA dehydrogenase FadE7; Rv0400c, (MTCY04D9.12c), len: 395 aa. Probable fadE7, acyl-CoA dehydrogenase, similar to many e.g. CAC12923.1|AL445403 putative acyl CoA dehydrogenase from Streptomyces coelicolor (397 aa); G624219 glutaryl-CoA dehydrogenase precursor (438 aa), FASTA scores: opt: 1161,E(): 0, (48.1% identity in 391 aa overlap); etc.
  
 0.849
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
Server load: medium (52%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.