STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Rv1979cPossible conserved permease; Probable amino-acid or metabolite transport protein. Belongs to the amino acid-polyamine-organocation (APC) superfamily. (481 aa)    
Predicted Functional Partners:
pepQ
Rv2535c, (MTCY159.21), len: 372 aa. Probable pepQ,cytoplasmic peptidase, equivalent to Q9CCS1|PEPQ|ML0521 putative cytoplasmic peptidase from Mycobacterium leprae (376 aa), FASTA scores: opt: 1954, E(): 1.1e-105, (82.7% identity in 376 aa overlap). Also similar to other peptidases e.g. P54518|YQHT_BACSU putative peptidase (belongs to peptidase family M24B) from Bacillus subtilis (353 aa), FASTA scores: opt: 808, E(): 1.6e-39, (39.65% identity in 368 aa overlap); Q9KXQ8|SC9C5.16c putative peptidase from Streptomyces coelicolor (368 aa), FASTA scores: opt: 803, E(): 3.2e-39, (43.15% iden [...]
  
 
 0.915
atpE
ATP synthase subunit c; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
  
  
 0.818
mmpR5
Conserved protein; Controls the expression level of the Mmps2-MmpL2, MmpS4- MmpL4, and MmpS5-MmpL5 transport systems. Also controls its own expression. Acts by binding directly to the promoter regions.
   
  
 0.811
treS
Trehalose synthase TreS; Catalyzes the reversible interconversion of maltose and trehalose by transglucosylation. Also displays amylase activity, catalyzing the endohydrolysis of (1->4)-alpha-D- glucosidic linkages in glycogen and maltooligosaccharides such as maltoheptaose, to produce maltose which then can be converted to trehalose. TreS plays a key role in the utilization of trehalose for the production of glycogen and alpha-glucan via the TreS-Pep2 branch involved in the biosynthesis of maltose-1-phosphate (M1P). Might also function as a sensor and/or regulator of trehalose levels [...]
  
 0.777
aglA
Alpha-glucosidase AglA; Rv2471, (MTV008.27), len: 546 aa. Probable aglA,maltase (alpha-glucosidase), highly similar or similar to several e.g. Q60027|AGLA from Thermomonospora curvata (544 aa), FASTA scores: opt: 2071, E(): 4e-116, (57.7% identity in 525 aa overlap); Q9KZE3|AGLAE from Streptomyces coelicolor (534 aa), FASTA scores: opt: 1475, E(): 1.5e-80,(50.1% identity in 537 aa overlap); O86874|AGLA from Streptomyces lividans (534 aa), FASTA scores: opt: 1473,E(): 2e-80, (50.1% identity in 537 aa overlap); etc. Seems to belong to family 13 of glycosyl hydrolases, also known as the a [...]
  
 0.777
glgE
Probable glucanase GlgE; Essential maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1->4)- glucans. Maltooligosaccharides with a degree of polymerization (DP) superior or equal to 4 are efficient acceptors, with DP5 being optimal in the GlgE-catalyzed polymerization with M1P. Is specific for the alpha-anomer of M1P as substrate, since the beta-anomer of M1P gives no activity. Exhibits an alpha-retaining catalytic mechanism. Is also able to catalyze the reverse reaction in vitro, releasing M1P from glycogen in the presence [...]
  
 0.775
mpt64
Immunogenic protein Mpt64 (antigen Mpt64/MPB64); Rv1980c, (MT2032, MTCY39.39), len: 228 aa. Mpt64 (alternate gene name: mpb64), immunogenic protein (alternate gene name: mpb64) (see citations below),identical to MPT64|MPB64 from Mycobacterium bovis (228 aa). Similar to Rv3036c|MTV012.51c from Mycobacterium tuberculosis. Exported protein containing a N-terminal signal sequence: see notes below about proteomics. Predicted possible vaccine candidate (See Zvi et al.,2008).
  
  
 0.735
mmpL5
Probable conserved transmembrane transport protein MmpL5; Part of an export system, which is required for biosynthesis and secretion of siderophores.
   
  
 0.630
Rv1978
Conserved protein; Rv1978, (MTV051.16), len: 282 aa. Conserved protein,similar to several hypothetical proteins and methyltransferases e.g. X86780|SHGCPIR.15 methyltransferase from S. hygroscopicus (211 aa), FASTA scores: opt: 151,E(): 0.0072, (30.6% identity in 121 aa overlap).
   
  
 0.629
Rv1453
Rv1453, (MTCY493.01c), len: 421 aa. Possible transcriptional activator, similar to Q50018 putative transcriptional activator trx from Mycobacterium leprae (517 aa), FASTA scores: opt: 1719, E(): 0, (54.0% identity in 500 aa overlap). Also highly similar to Mycobacterium tuberculosis proteins Rv2370c, Rv1194c, Rv2242, Rv1186c,and to the further upstream ORF's Rv1429|MTCY493.25c (28.1% identity in 335 aa overlap). Start changed since first submission (-11 aa).
  
  
 0.556
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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