node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rv1993c | Rv1995 | Rv1993c | Rv1995 | Conserved protein; Rv1993c, (MTCY39.26), len: 90 aa. Conserved protein,very similar to Rv3269|Z92771|MTCY71.09 hypothetical protein from Mycobacterium tuberculosis (93 aa), FASTA results: opt: 309, E(): 3.2e-16, (63.3% identity in 79 aa overlap). Also similar to Rv0968 (98 aa) (51.1% identity in 94 aa overlap). | Unknown protein; Rv1995, (MTCY39.24c), len: 255 aa. Unknown protein. | 0.918 |
Rv1993c | cmtR | Rv1993c | Rv1994c | Conserved protein; Rv1993c, (MTCY39.26), len: 90 aa. Conserved protein,very similar to Rv3269|Z92771|MTCY71.09 hypothetical protein from Mycobacterium tuberculosis (93 aa), FASTA results: opt: 309, E(): 3.2e-16, (63.3% identity in 79 aa overlap). Also similar to Rv0968 (98 aa) (51.1% identity in 94 aa overlap). | Metal sensor transcriptional regulator CmtR (ArsR-SmtB family); Metal-responsive transcriptional repressor for the cmt operon. Binding of cadmium or lead causes the repressor to dissociate from the DNA. | 0.935 |
Rv1993c | ctpG | Rv1993c | Rv1992c | Conserved protein; Rv1993c, (MTCY39.26), len: 90 aa. Conserved protein,very similar to Rv3269|Z92771|MTCY71.09 hypothetical protein from Mycobacterium tuberculosis (93 aa), FASTA results: opt: 309, E(): 3.2e-16, (63.3% identity in 79 aa overlap). Also similar to Rv0968 (98 aa) (51.1% identity in 94 aa overlap). | Rv1992c, (MTCY39.27), len: 771 aa. Probable ctpG,metal cation-transporting P-type ATPase G (transmembrane protein), similar to others, especially cadmium-transporting ATPases, e.g. NP_244904.1|NC_002570 cadmium-transporting ATPase from Bacillus halodurans (707 aa); P30336|CADA_BACFI probable cadmium-transporting ATPase from Bacillus firmus (723 aa); BAB47609.1|AB037671 cadmium resistance protein B from Staphylococcus aureus (804 aa); 3121832|Q60048|CADA_LISMO probable cadmium-transporting ATPase from Listeria monocytogenes (707 aa); etc. Also similar to others from Mycobacterium tuberc [...] | 0.992 |
Rv1993c | mazE6 | Rv1993c | Rv1991A | Conserved protein; Rv1993c, (MTCY39.26), len: 90 aa. Conserved protein,very similar to Rv3269|Z92771|MTCY71.09 hypothetical protein from Mycobacterium tuberculosis (93 aa), FASTA results: opt: 309, E(): 3.2e-16, (63.3% identity in 79 aa overlap). Also similar to Rv0968 (98 aa) (51.1% identity in 94 aa overlap). | Antitoxin MazE6; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and in M.smegmatis counteracts the ribonuclease activity of cognate toxin MazF6. | 0.536 |
Rv1993c | mazF6 | Rv1993c | Rv1991c | Conserved protein; Rv1993c, (MTCY39.26), len: 90 aa. Conserved protein,very similar to Rv3269|Z92771|MTCY71.09 hypothetical protein from Mycobacterium tuberculosis (93 aa), FASTA results: opt: 309, E(): 3.2e-16, (63.3% identity in 79 aa overlap). Also similar to Rv0968 (98 aa) (51.1% identity in 94 aa overlap). | Toxin MazF6; Toxic component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and in M.smegmatis partially inhibits cell growth and colony formation; its toxic effect is neutralized by coexpression with cognate antitoxin MazE6. Acts as an mRNA interferase on ssRNA, cleaving between the second and third bases in the sequences CUCCU and UUCCU. Further experiments demonstrate that it digests between the first and second bases of UCCUU, yielding a 5'- hydroxyl end; digests M.tuberculosis mRNA (in coding as well as the 5'- and 3'-UTR regions) and 23S rRNA, digests E.coli [...] | 0.550 |
Rv1995 | Rv1993c | Rv1995 | Rv1993c | Unknown protein; Rv1995, (MTCY39.24c), len: 255 aa. Unknown protein. | Conserved protein; Rv1993c, (MTCY39.26), len: 90 aa. Conserved protein,very similar to Rv3269|Z92771|MTCY71.09 hypothetical protein from Mycobacterium tuberculosis (93 aa), FASTA results: opt: 309, E(): 3.2e-16, (63.3% identity in 79 aa overlap). Also similar to Rv0968 (98 aa) (51.1% identity in 94 aa overlap). | 0.918 |
Rv1995 | cmtR | Rv1995 | Rv1994c | Unknown protein; Rv1995, (MTCY39.24c), len: 255 aa. Unknown protein. | Metal sensor transcriptional regulator CmtR (ArsR-SmtB family); Metal-responsive transcriptional repressor for the cmt operon. Binding of cadmium or lead causes the repressor to dissociate from the DNA. | 0.732 |
Rv1995 | ctpG | Rv1995 | Rv1992c | Unknown protein; Rv1995, (MTCY39.24c), len: 255 aa. Unknown protein. | Rv1992c, (MTCY39.27), len: 771 aa. Probable ctpG,metal cation-transporting P-type ATPase G (transmembrane protein), similar to others, especially cadmium-transporting ATPases, e.g. NP_244904.1|NC_002570 cadmium-transporting ATPase from Bacillus halodurans (707 aa); P30336|CADA_BACFI probable cadmium-transporting ATPase from Bacillus firmus (723 aa); BAB47609.1|AB037671 cadmium resistance protein B from Staphylococcus aureus (804 aa); 3121832|Q60048|CADA_LISMO probable cadmium-transporting ATPase from Listeria monocytogenes (707 aa); etc. Also similar to others from Mycobacterium tuberc [...] | 0.636 |
cmtR | Rv1993c | Rv1994c | Rv1993c | Metal sensor transcriptional regulator CmtR (ArsR-SmtB family); Metal-responsive transcriptional repressor for the cmt operon. Binding of cadmium or lead causes the repressor to dissociate from the DNA. | Conserved protein; Rv1993c, (MTCY39.26), len: 90 aa. Conserved protein,very similar to Rv3269|Z92771|MTCY71.09 hypothetical protein from Mycobacterium tuberculosis (93 aa), FASTA results: opt: 309, E(): 3.2e-16, (63.3% identity in 79 aa overlap). Also similar to Rv0968 (98 aa) (51.1% identity in 94 aa overlap). | 0.935 |
cmtR | Rv1995 | Rv1994c | Rv1995 | Metal sensor transcriptional regulator CmtR (ArsR-SmtB family); Metal-responsive transcriptional repressor for the cmt operon. Binding of cadmium or lead causes the repressor to dissociate from the DNA. | Unknown protein; Rv1995, (MTCY39.24c), len: 255 aa. Unknown protein. | 0.732 |
cmtR | ctpA | Rv1994c | Rv0092 | Metal sensor transcriptional regulator CmtR (ArsR-SmtB family); Metal-responsive transcriptional repressor for the cmt operon. Binding of cadmium or lead causes the repressor to dissociate from the DNA. | Cation transporter P-type ATPase a CtpA; Involved in copper export. Could be involved in the copper detoxification of mycobacterial cells; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily. | 0.412 |
cmtR | ctpG | Rv1994c | Rv1992c | Metal sensor transcriptional regulator CmtR (ArsR-SmtB family); Metal-responsive transcriptional repressor for the cmt operon. Binding of cadmium or lead causes the repressor to dissociate from the DNA. | Rv1992c, (MTCY39.27), len: 771 aa. Probable ctpG,metal cation-transporting P-type ATPase G (transmembrane protein), similar to others, especially cadmium-transporting ATPases, e.g. NP_244904.1|NC_002570 cadmium-transporting ATPase from Bacillus halodurans (707 aa); P30336|CADA_BACFI probable cadmium-transporting ATPase from Bacillus firmus (723 aa); BAB47609.1|AB037671 cadmium resistance protein B from Staphylococcus aureus (804 aa); 3121832|Q60048|CADA_LISMO probable cadmium-transporting ATPase from Listeria monocytogenes (707 aa); etc. Also similar to others from Mycobacterium tuberc [...] | 0.892 |
cmtR | mazE6 | Rv1994c | Rv1991A | Metal sensor transcriptional regulator CmtR (ArsR-SmtB family); Metal-responsive transcriptional repressor for the cmt operon. Binding of cadmium or lead causes the repressor to dissociate from the DNA. | Antitoxin MazE6; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and in M.smegmatis counteracts the ribonuclease activity of cognate toxin MazF6. | 0.462 |
cmtR | mazF6 | Rv1994c | Rv1991c | Metal sensor transcriptional regulator CmtR (ArsR-SmtB family); Metal-responsive transcriptional repressor for the cmt operon. Binding of cadmium or lead causes the repressor to dissociate from the DNA. | Toxin MazF6; Toxic component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and in M.smegmatis partially inhibits cell growth and colony formation; its toxic effect is neutralized by coexpression with cognate antitoxin MazE6. Acts as an mRNA interferase on ssRNA, cleaving between the second and third bases in the sequences CUCCU and UUCCU. Further experiments demonstrate that it digests between the first and second bases of UCCUU, yielding a 5'- hydroxyl end; digests M.tuberculosis mRNA (in coding as well as the 5'- and 3'-UTR regions) and 23S rRNA, digests E.coli [...] | 0.435 |
ctpA | cmtR | Rv0092 | Rv1994c | Cation transporter P-type ATPase a CtpA; Involved in copper export. Could be involved in the copper detoxification of mycobacterial cells; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily. | Metal sensor transcriptional regulator CmtR (ArsR-SmtB family); Metal-responsive transcriptional repressor for the cmt operon. Binding of cadmium or lead causes the repressor to dissociate from the DNA. | 0.412 |
ctpA | ctpG | Rv0092 | Rv1992c | Cation transporter P-type ATPase a CtpA; Involved in copper export. Could be involved in the copper detoxification of mycobacterial cells; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily. | Rv1992c, (MTCY39.27), len: 771 aa. Probable ctpG,metal cation-transporting P-type ATPase G (transmembrane protein), similar to others, especially cadmium-transporting ATPases, e.g. NP_244904.1|NC_002570 cadmium-transporting ATPase from Bacillus halodurans (707 aa); P30336|CADA_BACFI probable cadmium-transporting ATPase from Bacillus firmus (723 aa); BAB47609.1|AB037671 cadmium resistance protein B from Staphylococcus aureus (804 aa); 3121832|Q60048|CADA_LISMO probable cadmium-transporting ATPase from Listeria monocytogenes (707 aa); etc. Also similar to others from Mycobacterium tuberc [...] | 0.456 |
ctpA | ctpI | Rv0092 | Rv0107c | Cation transporter P-type ATPase a CtpA; Involved in copper export. Could be involved in the copper detoxification of mycobacterial cells; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily. | Rv0107c, (MTCY251.26c, MTV031.01c), len: 1632 aa. Probable ctpI, cation-transporting ATPase I P-type, highly similar to NP_302704.1|NC_002677 probable cation transport ATPase from Mycobacterium leprae (1609 aa); and similar to others e.g. CAB69720.1|AL137166 putative transport ATPase from Streptomyces coelicolor (1472 aa); ATA1_SYNY|P37367 cation-transporting ATPase pma1 from Synechocystis sp. (915 aa), FASTA scores: opt: 603, E(): 6.6e-29, (32.4% identity in 710 aa overlap); etc. Also similar to MTCY39.21c and MTCY22G10.22c from Mycobacterium tuberculosis, FASTA score: (34.4% identity [...] | 0.429 |
ctpA | mmcO | Rv0092 | Rv0846c | Cation transporter P-type ATPase a CtpA; Involved in copper export. Could be involved in the copper detoxification of mycobacterial cells; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily. | Probable oxidase; Required for copper resistance. In vitro, oxidizes organic substrates and Fe(2+). May act in vivo by oxidation of toxic periplasmic Cu(+); Belongs to the multicopper oxidase family. | 0.503 |
ctpA | sodC | Rv0092 | Rv0432 | Cation transporter P-type ATPase a CtpA; Involved in copper export. Could be involved in the copper detoxification of mycobacterial cells; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily. | Periplasmic superoxide dismutase [Cu-Zn] SodC; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. May play a role in favoring mycobacterial survival in phagocytes (By similarity). | 0.585 |
ctpF | ctpG | Rv1997 | Rv1992c | Rv1997, (MTCY39.22c, MTCY39.21c), len: 905 aa. Probable ctpF, metal cation-transporting P-type ATPase F (transmembrane protein), highly similar to others e.g. NP_250120.1|NC_002516 probable cation-transporting P-type ATPase from Pseudomonas aeruginosa (902 aa); NP_441217.1|NC_000911 cation-transporting ATPase (E1-E2 ATPase) from Synechocystis sp. strain PCC 6803 (905 aa); NP_404093.1|NC_003143 putative cation-transporting P-type ATPase from Yersinia pestis (908 aa); P37367|ATA1_SYNY3 cation-transporting ATPase pma1 from Synechocystis sp. (915 aa), FASTA scores: opt: 2392, E(): 0, (46.5 [...] | Rv1992c, (MTCY39.27), len: 771 aa. Probable ctpG,metal cation-transporting P-type ATPase G (transmembrane protein), similar to others, especially cadmium-transporting ATPases, e.g. NP_244904.1|NC_002570 cadmium-transporting ATPase from Bacillus halodurans (707 aa); P30336|CADA_BACFI probable cadmium-transporting ATPase from Bacillus firmus (723 aa); BAB47609.1|AB037671 cadmium resistance protein B from Staphylococcus aureus (804 aa); 3121832|Q60048|CADA_LISMO probable cadmium-transporting ATPase from Listeria monocytogenes (707 aa); etc. Also similar to others from Mycobacterium tuberc [...] | 0.517 |